_EC 2.1.1.190 23S rRNA (uracil(1939)-C(5))-methyltransferase. 2 PDB entries  
EC 2.-.-.- Transferases. [17,943 PDB entries]
EC 2.1.-.- Transferring one-carbon groups. [1,710 PDB entries]
EC 2.1.1.- Methyltransferases. [1,380 PDB entries]
EC 2.1.1.190 23S rRNA (uracil(1939)-C(5))-methyltransferase. [2 PDB entries]    
1uwv

Reaction: S-adenosyl-L-methionine + uracil(1939) in 23S rRNA = S-adenosyl-L- homocysteine + 5-methyluracil(1939) in 23S rRNA.
 


S-adenosyl-L-methionine
+ uracil(1939) in 23S rRNA
=
S-adenosyl-L- homocysteine
+ 5-methyluracil(1939) in 23S rRNA
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Rna uridine methyltransferase a.
Comments: The enzyme specifically methylates uracil(1939) at C(5) in 23S rRNA. The enzyme contains an [4Fe-4S] cluster coordinated by four conserved cysteine residues.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 2 PDB entries in enzyme class E.C.2.1.1.190

  PDB code Protein
1uwv
Crystal structure of ruma, the iron-sulfur cluster containing e. Coli 23s ribosomal RNA 5-methyluridine methyltransferase
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (418 residues) CATH domains: 2.40.50.140 3.40.50.150
2bh2
Crystal structure of e. Coli 5-methyluridine methyltransferase ruma in complex with ribosomal RNA substrate and s-adenosylhomocysteine.
Source: Escherichia coli. Organism_taxid: 562. Strain: k12. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Strain: k12
Chains: A, B (418 residues) CATH domains: 2.40.50.140 3.40.50.150