_EC 2.1.1.188 23S rRNA (guanine(748)-N(1))-methyltransferase. 0 PDB entries  
EC 2.-.-.- Transferases. [17,943 PDB entries]
EC 2.1.-.- Transferring one-carbon groups. [1,710 PDB entries]
EC 2.1.1.- Methyltransferases. [1,380 PDB entries]
EC 2.1.1.188 23S rRNA (guanine(748)-N(1))-methyltransferase. [-]    

Reaction: S-adenosyl-L-methionine + guanine(748) in 23S rRNA = S-adenosyl-L- homocysteine + N(1)-methylguanine(748) in 23S rRNA.
 


S-adenosyl-L-methionine
+ guanine(748) in 23S rRNA
=
S-adenosyl-L- homocysteine
+ N(1)-methylguanine(748) in 23S rRNA
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): 23S rRNA m(1)G(748) methyltransferase. rRNA large subunit methyltransferase Ii. Tylosin-resistance methyltransferase RlmA(II).
Comments: The enzyme specifically methylates guanine(748) at N(1) in 23S rRNA. The methyltransferase RlmA(II) confers resistance to the macrolide antibiotic tylosin in the drug-producing strain Streptomyces fradiae. Formerly Ec 2.1.1.51.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are no PDB entries in enzyme class E.C.2.1.1.188