_EC 2.1.1.174 23S rRNA (guanine(1835)-N(2))-methyltransferase. 1 PDB entries  
EC 2.-.-.- Transferases. [17,949 PDB entries]
EC 2.1.-.- Transferring one-carbon groups. [1,711 PDB entries]
EC 2.1.1.- Methyltransferases. [1,381 PDB entries]
EC 2.1.1.174 23S rRNA (guanine(1835)-N(2))-methyltransferase. [1 PDB entries]    
4dcm

Reaction: S-adenosyl-L-methionine + guanine(1835) in 23S rRNA = S-adenosyl-L- homocysteine + N(2)-methylguanine(1835) in 23S rRNA.
 


S-adenosyl-L-methionine
+ guanine(1835) in 23S rRNA
=
S-adenosyl-L- homocysteine
+ N(2)-methylguanine(1835) in 23S rRNA
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Ribosomal Rna large subunit methyltransferase g.
Comments: The enzyme methylates 23S rRNA in vitro, assembled 50S subunits are not a substrate. The enzyme specifically methylates guanine(1835) at N(2) in 23S rRNA. Formerly Ec 2.1.1.52.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 1 PDB entries in enzyme class E.C.2.1.1.174

  PDB code Protein
4dcm
Crystal structure of methyltransferase rlmg modifying g1835 rrna in escherichia coli
Source: Escherichia coli. Organism_taxid: 83333. Strain: k-12. Gene: b3084, jw5513, rlmg, ygjo. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (360 residues) CATH domains: Unassigned 3.40.50.150
Bound ligand:   Het Group SAM corresponds to enzyme reactant S-adenosyl-L-methionine