_EC 2.1.1.173 23S rRNA (guanine(2445)-N(2))-methyltransferase. 2 PDB entries  
EC 2.-.-.- Transferases. [17,949 PDB entries]
EC 2.1.-.- Transferring one-carbon groups. [1,711 PDB entries]
EC 2.1.1.- Methyltransferases. [1,381 PDB entries]
EC 2.1.1.173 23S rRNA (guanine(2445)-N(2))-methyltransferase. [2 PDB entries]    
3v8v

Reaction: S-adenosyl-L-methionine + guanine(2445) in 23S rRNA = S-adenosyl-L- homocysteine + N(2)-methylguanine(2445) in 23S rRNA.
 


S-adenosyl-L-methionine
+ guanine(2445) in 23S rRNA
=
S-adenosyl-L- homocysteine
+ N(2)-methylguanine(2445) in 23S rRNA
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Comments: The enzyme methylates 23S rRNA in vitro, assembled 50S subunits are not a substrate. The enzyme specifically methylates guanine(2445) at N(2) in 23S rRNA. Formerly Ec 2.1.1.52.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 2 PDB entries in enzyme class E.C.2.1.1.173

  PDB code Protein
3v8v
Crystal structure of bifunctional methyltransferase ycby (rl escherichia coli, sam binding
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: rlml. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (664 residues) CATH domains: Unassigned 3.40.50.150 Unassigned 3.40.50.150
Bound ligand:   Het Group SAM corresponds to enzyme product S-adenosylhomocysteine
3v97
Crystal structure of bifunctional methyltransferase ycby (rl escherichia coli, sah binding
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: rlml. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (667 residues) CATH domains: Unassigned 3.40.50.150 Unassigned 3.40.50.150
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine