_EC 2.1.1.167 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase. 0 PDB entries  
EC 2.-.-.- Transferases. [17,949 PDB entries]
EC 2.1.-.- Transferring one-carbon groups. [1,711 PDB entries]
EC 2.1.1.- Methyltransferases. [1,381 PDB entries]
EC 2.1.1.167 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase. [-]    

Reaction: S-adenosyl-L-methionine + guanosine(2922) in 27S pre-rRNA = S-adenosyl-L- homocysteine + 2'-O-methylguanosine(2922) in 27S pre-rRNA.
 


S-adenosyl-L-methionine
+ guanosine(2922) in 27S pre-rRNA
=
S-adenosyl-L- homocysteine
+ 2'-O-methylguanosine(2922) in 27S pre-rRNA
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Comments: Spb1p is a site-specific 2'-O-ribose Rna methyltransferase that catalyzes the formation of 2'-O-methylguanosine(2922), a universally conserved position of the catalytic center of the ribosome that is essential for translation. 2'-O-Methylguanosine(2922) is formed at a later stage of the processing, during the maturation of of the 27S pre-rRNA. In absence of snR52, Spb1p can also catalyze the formation of uridine(2921).
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There are no PDB entries in enzyme class E.C.2.1.1.167