_EC 2.1.1.150 Isoflavone 7-O-methyltransferase. 2 PDB entries  
EC 2.-.-.- Transferases. [17,949 PDB entries]
EC 2.1.-.- Transferring one-carbon groups. [1,711 PDB entries]
EC 2.1.1.- Methyltransferases. [1,381 PDB entries]
EC 2.1.1.150 Isoflavone 7-O-methyltransferase. [2 PDB entries]    
1fp2

Pathway: Formononetin and Derivatives Biosynthesis
Reaction: S-adenosyl-L-methionine + a 7-hydroxyisoflavone = S-adenosyl-L- homocysteine + a 7-methoxyisoflavone.
 


S-adenosyl-L-methionine
+
7-hydroxyisoflavone
=
S-adenosyl-L- homocysteine
+
7-methoxyisoflavone
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Comments: The enzyme from alfalfa can methylate daidzein, genistein and 6,7,4'-trihydroxyisoflavone but not flavones or flavanones.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 2 PDB entries in enzyme class E.C.2.1.1.150

  PDB code Protein
1fp2
Crystal structure analysis of isoflavone o-methyltransferase
Source: Medicago sativa. Organism_taxid: 3879. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (345 residues) CATH domains: 1.10.10.10 3.40.50.150
Bound ligands:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
  Het Group HMO is 95.00% similar to enzyme product 7-methoxyisoflavone
1fpx
Crystal structure analysis of selenomethionine substituted i o-methyltransferase
Source: Medicago sativa. Organism_taxid: 3879. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (345 residues) CATH domains: 1.10.10.10 3.40.50.150
Bound ligand:   Het Group SAM corresponds to enzyme reactant S-adenosyl-L-methionine