_EC 1.97.1.10 Thyroxine 5'-deiodinase. 0 PDB entries  
EC 1.-.-.- Oxidoreductases. [8,621 PDB entries]
EC 1.97.-.- Other oxidoreductases. [21 PDB entries]
EC 1.97.1.- Sole sub-subclass for oxidoreductases that do not belong in the o [21 PDB entries]
EC 1.97.1.10 Thyroxine 5'-deiodinase. [-]    

Reaction: 3,5,3'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH(2).
 


3,5,3'-triiodo-L-thyronine
+ iodide
+
+ H(+)
=
L-thyroxine
+ AH(2)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Diiodothyronine 5'-deiodinase. Iodothyronine 5'-deiodinase. Iodothyronine outer ring monodeiodinase. L-thyroxine iodohydrolase (reducing). Thyroxine 5-deiodinase. Type I iodothyronine deiodinase. Type Ii iodothyronine deiodinase.
Comments: The enzyme activity has only been demonstrated in the direction of 5'-deiodination, which renders the thyroid hormone more active. The enzyme consists of type I and type ii enzymes, both containing selenocysteine, but with different kinetics. For the type I enzyme the first reaction is a reductive deiodination converting the -Se-H group of the enzyme into an -Se-I group; the reductant then reconverts this into -Se-H, releasing iodide. Formerly Ec 3.8.1.4.
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There are no PDB entries in enzyme class E.C.1.97.1.10