_EC 1.8.1.9 Thioredoxin-disulfide reductase. 47 PDB entries  
EC 1.-.-.- Oxidoreductases. [8,444 PDB entries]
EC 1.8.-.- Acting on a sulfur group of donors. [333 PDB entries]
EC 1.8.1.- With NAD(+) or NADP(+) as acceptor. [192 PDB entries]
EC 1.8.1.9 Thioredoxin-disulfide reductase. [47 PDB entries]    
1cl0

Reaction: Thioredoxin + NADP(+) = thioredoxin disulfide + Nadph.
 


Thioredoxin
+
NADP(+)
=
thioredoxin disulfide
+
NADPH
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): NADP--thioredoxin reductase. NADPH--thioredoxin reductase. NADPH:oxidized thioredoxin oxidoreductase. Thioredoxin reductase (NADPH).
Comments: May be identical to Ec 1.8.1.10. Formerly Ec 1.6.4.5.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 47 PDB entries in enzyme class E.C.1.8.1.9

  PDB code Protein
1cl0
Crystal structure of reduced thioredoxin reductase from esch coli.
Source: Escherichia coli. Organism_taxid: 562. Gene: trxb. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: trxb-strain
Chain: A (317 residues) CATH domains: 3.50.50.60 3.50.50.60
Bound ligand:   Het Group FAD is 71.19% similar to enzyme reactant NADP(+)
1f6m
Crystal structure of a complex between thioredoxin reductase, thioredoxin, and the NADP+ analog, aadp+
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B, E, F (320 residues) CATH domains: 3.50.50.60 3.50.50.60
Bound ligand:   Het Group 3AA is 91.00% similar to enzyme reactant NADP(+)
1h6v
Mammalian thioredoxin reductase
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Cell_line: pc-12. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F (490 residues) CATH domains: 3.50.50.60 3.50.50.60 3.30.390.30
Bound ligand:   Het Group FAD is 71.00% similar to enzyme reactant NADP(+)
1tde
Crystal structure of escherichia coli thioredoxin reductase 2 angstrom resolution: implications for a large conformatio during catalysis
Source: Escherichia coli. Organism_taxid: 562
Chain: A (316 residues) CATH domains: 3.50.50.60 3.50.50.60
Bound ligand:   Het Group FAD is 71.19% similar to enzyme reactant NADP(+)
1tdf
Crystal structure of escherichia coli thioredoxin reductase 2 angstrom resolution: implications for a large conformatio during catalysis
Source: Escherichia coli. Organism_taxid: 562
Chain: A (316 residues) CATH domains: 3.50.50.60 3.50.50.60
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
1trb
Convergent evolution of similar function in two structurally enzymes
Source: Escherichia coli. Organism_taxid: 562
Chain: A (316 residues) CATH domains: 3.50.50.60 3.50.50.60
Bound ligand:   Het Group FAD is 71.19% similar to enzyme reactant NADP(+)
1vdc
Structure of NADPH dependent thioredoxin reductase
Source: Arabidopsis thaliana. Thale cress. Organism_taxid: 3702. Gene: atthiredb. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: pet
Chain: A (322 residues) CATH domains: 3.50.50.60 3.50.50.60
Bound ligand:   Het Group FAD is 71.19% similar to enzyme reactant NADP(+)
1w1c
Human cytoplasmic thioredoxin reductase (txn1) in complex with thioredoxin (trx)
Source: Homo sapiens. Human. Tissue: placenta, brain. Cellular_location: cytoplasm. Human
Chains: A, B (489 residues)
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
1w1e
Mitochondrial human thioredoxin reductase in complex with thioredoxin
Source: Homo sapiens. Human. Tissue: placenta, brain, cervical carcinoma. Cellular_location: mitochondrial. Human
Chains: A, B (489 residues)
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
1zdl
Crystal structure of mouse thioredoxin reductase type 2
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: txnrd2, trxr2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (484 residues) CATH domains: 3.50.50.60 3.50.50.60 3.30.390.30
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
1zkq
Crystal structure of mouse thioredoxin reductase type 2
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: txnrd2, trxr2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (482 residues) CATH domains: 3.50.50.60 3.50.50.60 3.30.390.30
Bound ligand:   Het Group FAD is 71.19% similar to enzyme reactant NADP(+)
2a87
Crystal structure of m. Tuberculosis thioredoxin reductase
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: trxb. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (313 residues) CATH domains: 3.50.50.60 3.50.50.60
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
2cfy
Crystal structure of human thioredoxin reductase 1
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: bl21(de3)-r3.
Chains: A, B, C, D, E, F (484 residues) CATH domains: 3.50.50.60 3.50.50.60 3.30.390.30
Bound ligand:   Het Group FAD is 71.19% similar to enzyme reactant NADP(+)
2j3n
X-ray structure of human thioredoxin reductase 1
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: uterus. Tissue: placenta. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_variant: m15. Other_details: cdna from human placenta used for cloning
Chains: A, B, C, D, E, F (487 residues) CATH domains: 3.50.50.60 3.50.50.60 3.30.390.30
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
2lv3
Structure-functional characterization of grx domain of mus m tgr
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: tgr. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (102 residues) CATH domain: 3.40.30.10
2nvk
Crystal structure of thioredoxin reductase from drosophila melanogaster
Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Gene: trxr-1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: X (481 residues) CATH domains: 3.50.50.60 3.50.50.60 3.30.390.30
Bound ligand:   Het Group FAD is 71.19% similar to enzyme reactant NADP(+)
2q0k
Oxidized thioredoxin reductase from helicobacter pylori in c with NADP+
Source: Helicobacter pylori. Organism_taxid: 85962. Strain: 26695. Gene: trxb. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (310 residues) CATH domains: 3.50.50.60 3.50.50.60
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
2q0l
Helicobacter pylori thioredoxin reductase reduced by sodium in complex with NADP+
Source: Helicobacter pylori. Organism_taxid: 85962. Strain: 26695. Gene: trxb. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (311 residues) CATH domains: 3.50.50.60 3.50.50.60
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
2q7v
Crystal structure of deinococcus radiodurans thioredoxin reductase
Source: Deinococcus radiodurans. Organism_taxid: 1299. Strain: r1. Gene: trxb. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (313 residues) CATH domains: 3.50.50.60 3.50.50.60
Bound ligand:   Het Group FAD is 71.00% similar to enzyme reactant NADP(+)
2whd
Barley NADPH-dependent thioredoxin reductase 2
Source: Hordeum vulgare. Barley. Organism_taxid: 4513. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (318 residues) CATH domains: 3.50.50.60 3.50.50.60
Bound ligand:   Het Group FAD is 71.00% similar to enzyme reactant NADP(+)
2ynx
Crystal structure of ancestral thioredoxin relative to last archaea common ancestor (laca) from the precambrian period
Source: Synthetic construct. Organism_taxid: 32630. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (105 residues) CATH domain: 3.40.30.10
2yoi
Crystal structure of ancestral thioredoxin relative to last eukaryotes common ancestor (leca) from the precambrian peri
Source: Synthetic construct. Organism_taxid: 32630. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: ancestral, reconstructed phylogenetically
Chains: A, B (106 residues) CATH domain: 3.40.30.10
2ypm
Crystal structure of ancestral thioredoxin relative to last and fungi common ancestor (lafca) from the precambrian peri
Source: Synthetic construct. Organism_taxid: 32630. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (105 residues) CATH domain: 3.40.30.10
2zz0
Crystal structure of human thioredoxin reductase i (secys 498 cys)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: txnrd1, kdrf. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (491 residues) CATH domains: 3.50.50.60 3.50.50.60 3.30.390.30
Bound ligand:   Het Group FAD is 71.00% similar to enzyme reactant NADP(+)
2zzb
Crystal structure of human thioredoxin reductase i and terpyridine platinum(ii)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: txnrd1, kdrf. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (490 residues) CATH domains: 3.50.50.60 3.50.50.60 3.30.390.30
Bound ligand:   Het Group FAD is 71.00% similar to enzyme reactant NADP(+)
2zzc
Crystal structure of NADP(h):human thioredoxin reductase i
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: txnrd1, kdrf. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (485 residues) CATH domains: 3.50.50.60 3.50.50.60 3.30.390.30
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
3d8x
Crystal structure of saccharomyces cerevisiae ndpph dependen thioredoxin reductase 1
Source: Saccharomyces cerevisiae. Organism_taxid: 4932. Strain: s288c. Gene: trr1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (318 residues) CATH domains: 3.50.50.60 3.50.50.60
Bound ligand:   Het Group FAD is 71.19% similar to enzyme reactant NADP(+)
3dgh
Crystal structure of drosophila thioredoxin reductase, c-ter residue truncation
Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Gene: trxr-1, gr, cg2151. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (477 residues) CATH domains: 3.50.50.60 3.50.50.60 3.30.390.30
Bound ligand:   Het Group FAD is 71.19% similar to enzyme reactant NADP(+)
3dgz
Crystal structure of mouse mitochondrial thioredoxin reducta terminal 3-residue truncation
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: txnrd2, trxr2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (482 residues) CATH domains: 3.50.50.60 3.50.50.60 3.30.390.30
Bound ligand:   Het Group FAD is 71.19% similar to enzyme reactant NADP(+)
3dh9
Crystal structure of drosophila thioredoxin reductase, wild-
Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Gene: trxr-1, gr, cg2151. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (482 residues) CATH domains: 3.50.50.60 3.50.50.60 3.30.390.30
Bound ligand:   Het Group FAD is 71.19% similar to enzyme reactant NADP(+)
3ean
Crystal structure of recombinant rat selenoprotein thioredox reductase 1 with reduced c-terminal tail
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Strain: sprague-dawley. Gene: txnrd1, trxr1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F (490 residues) CATH domains: 3.50.50.60 3.50.50.60 3.30.390.30
Bound ligand:   Het Group FAD is 71.19% similar to enzyme reactant NADP(+)
3eao
Crystal structure of recombinant rat selenoprotein thioredox reductase 1 with oxidized c-terminal tail
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Strain: sprague-dawley. Gene: txnrd1, trxr1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F (489 residues) CATH domains: 3.50.50.60 3.50.50.60 3.30.390.30
Bound ligand:   Het Group FAD is 71.19% similar to enzyme reactant NADP(+)
3h8q
Crystal structure of glutaredoxin domain of human thioredoxi reductase 3
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgr, trxr3, txnrd3, txnrd3. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (108 residues) CATH domain: 3.40.30.10
3ish
Crystal structure of helicobacter pylori thioredoxin reducta
Source: Helicobacter pylori. Organism_taxid: 85962. Strain: 26695. Gene: hp0825. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (311 residues) CATH domains: 3.50.50.60 3.50.50.60
Bound ligand:   Het Group FAD is 71.19% similar to enzyme reactant NADP(+)
3itj
Crystal structure of saccharomyces cerevisiae thioredoxin re (trr1)
Source: Saccharomyces cerevisiae. Yeast. Organism_taxid: 580240. Strain: w303. Gene: d9476.5, trr1, ydr353w. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (317 residues) CATH domains: 3.50.50.60 3.50.50.60
Bound ligand:   Het Group FAD is 71.19% similar to enzyme reactant NADP(+)
3qfa
Crystal structure of the human thioredoxin reductase-thiored complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: grim12, kdrf, txnrd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: trdx, trx, trx1, txn.
Chains: A, B (494 residues) CATH domains: 3.50.50.60 3.50.50.60 3.30.390.30
Bound ligand:   Het Group FAD is 71.19% similar to enzyme reactant NADP(+)
3qfb
Crystal structure of the human thioredoxin reductase-thiored complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: grim12, kdrf, txnrd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: trdx, trx, trx1, txn.
Chains: A, B (495 residues) CATH domains: 3.50.50.60 3.50.50.60 3.30.390.30
Bound ligand:   Het Group FAD is 71.19% similar to enzyme reactant NADP(+)
3r9u
Thioredoxin-disulfide reductase from campylobacter jejuni.
Source: Campylobacter jejuni. Organism_taxid: 197. Strain: subsp. Jejuni nctc 11168. Gene: cj0146c, trxb. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (314 residues) CATH domains: 3.50.50.60 3.50.50.60
Bound ligand:   Het Group FAD is 71.19% similar to enzyme reactant NADP(+)
3ziv
Crystal structure of ancestral thioredoxin relative to last archaea-eu
Source: Synthetic construct. Organism_taxid: 32630. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (105 residues) CATH domain: 3.40.30.10
4a5l
Crystal structure of the thioredoxin reductase from entamoeb histolytica
Source: Entamoeba histolytica. Organism_taxid: 5759. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (313 residues) CATH domains: 3.50.50.60 3.50.50.60
Bound ligand:   Het Group FAD is 71.19% similar to enzyme reactant NADP(+)
4a65
Crystal structure of the thioredoxin reductase from entamoeb histolytica with aucn
Source: Entamoeba histolytica. Organism_taxid: 5759. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (311 residues) CATH domains: 3.50.50.60 3.50.50.60
Bound ligand:   Het Group FAD is 71.19% similar to enzyme reactant NADP(+)
4b1b
Crystal structure of plasmodium falciparum oxidised thioredoxin reductase at 2.9 angstrom
Source: Plasmodium falciparum. Organism_taxid: 5833. Strain: isolate fch-5. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (437 residues) CATH domain: Unassigned
Bound ligand:   Het Group FAD is 71.19% similar to enzyme reactant NADP(+)
4gcm
Crystal structure of a thioredoxine reductase (trxb) from staphylococcus aureus subsp. Aureus mu50 at 1.80 a resoluti
Source: Staphylococcus aureus subsp. Aureus. Organism_taxid: 196620. Strain: mw2. Gene: trxb, mw0726. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (308 residues) CATH domains: 3.50.50.60 3.50.50.60
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
4j56
Structure of plasmodium falciparum thioredoxin reductase-thi complex
Source: Plasmodium falciparum. Organism_taxid: 36329. Strain: 3d7. Gene: trxr2, pfi1170c. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: pf14_0545.
Chains: A, B, C, D (504 residues) CATH domains: 3.50.50.60 3.50.50.60 3.30.390.30
Bound ligand:   Het Group FAD is 71.19% similar to enzyme reactant NADP(+)
4j57
Structure of plasmodium falciparum thioredoxin reductase-thi complex
Source: Plasmodium falciparum. Organism_taxid: 36329. Strain: 3d7. Gene: trxr2, pfi1170c. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: pf14_0545.
Chains: A, B (483 residues) CATH domains: 3.50.50.60 3.50.50.60 3.30.390.30
Bound ligand:   Het Group FAD is 71.19% similar to enzyme reactant NADP(+)
4jnq
Crystal structure of a thioredoxin reductase from brucella m
Source: Brucella melitensis bv. 1. Organism_taxid: 224914. Strain: 16m / atcc 23456 / nctc 10094. Gene: bawg_2493, bmei0512. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (315 residues) CATH domains: 3.50.50.60 3.50.50.60
Bound ligand:   Het Group FDA is 71.19% similar to enzyme reactant NADP(+)
4kpr
Tetrameric form of rat selenoprotein thioredoxin reductase 1
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: trxr1, txnrd1, txnrd1 trxr1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: E, F, A, B (484 residues) CATH domains: 3.50.50.60 3.50.50.60 3.30.390.30
Bound ligand:   Het Group FAD is 71.19% similar to enzyme reactant NADP(+)