_EC 1.6.2.2 Cytochrome-b5 reductase. 14 PDB entries  
EC 1.-.-.- Oxidoreductases. [8,844 PDB entries]
EC 1.6.-.- Acting on Nadh or nadph. [239 PDB entries]
EC 1.6.2.- With a heme protein as acceptor. [99 PDB entries]
EC 1.6.2.2 Cytochrome-b5 reductase. [14 PDB entries]    
1i7p

Reaction: Nadh + 2 ferricytochrome b5 = NAD(+) + H(+) + 2 ferrocytochrome b5.
 


NADH
+ 2 × ferricytochrome b5
=
NAD(+)
+ H(+)
+ 2 × ferrocytochrome b5
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Cofactor(s): Fad.
 

FAD
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 14 PDB entries in enzyme class E.C.1.6.2.2

  PDB code Protein
1i7p
Crystal structure of rat b5r in complex with fad
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: dia1. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (272 residues) CATH domains: 2.40.30.10 3.40.50.80
Bound ligand:   Het Group FAD corresponds to enzyme cofactor FAD
1ib0
Crystal structure of rat b5r in complex with fad and NAD
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: dia1. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (272 residues) CATH domains: 2.40.30.10 3.40.50.80
Bound ligands:   Het Group NAD corresponds to enzyme reactant NADH
  Het Group FAD corresponds to enzyme cofactor FAD
1m91
A theoretical model of nadh-cytochrome b5 reductase (human)
Source: Homo sapiens. Human
Chain: A (300 residues)
1ndh
Crystal structure of nadh-cytochrome b5 reductase from pig liver at 2.4 angstroms resolution
Source: Sus scrofa. Pig. Organism_taxid: 9823
Chain: A (270 residues) CATH domains: 2.40.30.10 3.40.50.80
Bound ligand:   Het Group FAD corresponds to enzyme cofactor FAD
1qx4
Structrue of s127p mutant of cytochrome b5 reductase
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: dia1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (264 residues) CATH domains: 2.40.30.10 3.40.50.80
Bound ligand:   Het Group FAD corresponds to enzyme cofactor FAD
1umk
The structure of human erythrocyte nadh-cytochrome b5 reductase
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (271 residues) CATH domains: 2.40.30.10 3.40.50.80
Bound ligand:   Het Group FAD corresponds to enzyme cofactor FAD
2eix
The structure of physarum polycephalum cytochrome b5 reducta
Source: Physarum polycephalum. Organism_taxid: 5791. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (243 residues) CATH domains: 2.40.30.10 3.40.50.80
Bound ligand:   Het Group FAD is 76.00% similar to enzyme reactant NADH
3lf5
Structure of human nadh cytochrome b5 oxidoreductase (ncb5or domain to 1.25a resolution
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cyb5r4, ncb5or. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (87 residues) CATH domain: 3.10.120.10
3w2e
Crystal structure of oxidation intermediate (20 min) of nadh cytochrome b5 reductase from pig liver
Source: Sus scrofa. Pig. Organism_taxid: 9823. Gene: cyb5r3, dia1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (271 residues) CATH domains: 2.40.30.10 3.40.50.80
Bound ligands:   Het Group NAD corresponds to enzyme reactant NADH
  Het Group FAD corresponds to enzyme cofactor FAD
3w2f
Crystal structure of oxidation intermediate (10 min) of nadh cytochrome b5 reductase from pig liver
Source: Sus scrofa. Pig. Organism_taxid: 9823. Gene: cyb5r3, dia1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (271 residues) CATH domains: 2.40.30.10 3.40.50.80
Bound ligands:   Het Group NAD corresponds to enzyme reactant NADH
  Het Group FAD corresponds to enzyme cofactor FAD
3w2g
Crystal structure of fully reduced form of nadh-cytochrome b reductase from pig liver
Source: Sus scrofa. Pig. Organism_taxid: 9823. Gene: cyb5r3, dia1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (271 residues) CATH domains: 2.40.30.10 3.40.50.80
Bound ligands:   Het Group NAD corresponds to enzyme reactant NADH
  Het Group FAD corresponds to enzyme cofactor FAD
3w2h
Crystal structure of oxidation intermediate (1min) of nadh-c b5 reductase from pig liver
Source: Sus scrofa. Pig. Organism_taxid: 9823. Gene: cyb5r3, dia1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (271 residues) CATH domains: 2.40.30.10 3.40.50.80
Bound ligands:   Het Group NAD corresponds to enzyme reactant NADH
  Het Group FAD corresponds to enzyme cofactor FAD
3w2i
Crystal structure of re-oxidized form (60 min) of nadh-cytoc reductase from pig liver
Source: Sus scrofa. Pig. Organism_taxid: 9823. Gene: cyb5r3, dia1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (271 residues) CATH domains: 2.40.30.10 3.40.50.80
Bound ligand:   Het Group FAD corresponds to enzyme cofactor FAD
3w5h
Ultra-high resolution structure of nadh-cytochrome b5 reduct
Source: Sus scrofa. Pigs,swine,wild boar. Organism_taxid: 9823. Gene: cyb5r3, dia1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (272 residues) CATH domains: 2.40.30.10 3.40.50.80
Bound ligand:   Het Group FAD corresponds to enzyme cofactor FAD