_EC 1.5.1.6 Formyltetrahydrofolate dehydrogenase. 17 PDB entries  
EC 1.-.-.- Oxidoreductases. [8,663 PDB entries]
EC 1.5.-.- Acting on the CH-NH group of donors. [619 PDB entries]
EC 1.5.1.- With NAD(+) or NADP(+) as acceptor. [481 PDB entries]
EC 1.5.1.6 Formyltetrahydrofolate dehydrogenase. [17 PDB entries]    
1s3i

Pathway: Folate Coenzymes
Reaction: 10-formyltetrahydrofolate + NADP(+) + H(2)O = tetrahydrofolate + CO(2) + Nadph.
 


10-formyltetrahydrofolate
+
NADP(+)
+ H(2)O
=
tetrahydrofolate
+
CO(2)
+
NADPH
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): 10-formyltetrahydrofolate dehydrogenase.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 17 PDB entries in enzyme class E.C.1.5.1.6

  PDB code Protein
1s3i
Crystal structure of the n terminal hydrolase domain of 10- formyltetrahydrofolate dehydrogenase
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: fthfd. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (307 residues) CATH domains: 3.40.50.170 3.10.25.10
Bound ligand:   Het Group BME is 40.00% similar to enzyme product CO(2)
2bw0
Crystal structure of the hydrolase domain of human 10-formyltetrahydrofolate 2 dehydrogenase
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (309 residues) CATH domains: 3.40.50.170 3.10.25.10
2cfi
The hydrolase domain of human 10-fthfd in complex with 6- formyltetrahydropterin
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (310 residues) CATH domains: 3.40.50.170 3.10.25.10
2cq8
Solution structure of rsgi ruh-033, a pp-binding domain of 10-fthfdh from human cdna
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fthfd. Other_details: cell-free protein synthesis
Chain: A (110 residues) CATH domain: 1.10.1200.10
2o2p
Crystal structure of thE C-terminal domain of rat 10'formyltetrahydrofolate dehydrogenase
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: fthfd. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B, C, D (498 residues) CATH domains: 3.40.605.10 3.40.309.10
2o2q
Crystal structure of thE C-terminal domain of rat 10'formyltetrahydrofolate dehydrogenase in complex with nad
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: fthfd. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B, C, D (498 residues) CATH domains: 3.40.605.10 3.40.309.10
2o2r
Crystal structure of thE C-terminal domain of rat 10'formyltetrahydrofolate dehydrogenase in complex with nad
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: fthfd. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B, C, D (498 residues) CATH domains: 3.40.605.10 3.40.309.10
3rhj
Crystal structure of the e673a mutant of thE C-terminal doma 10'formyltetrahydrofolate dehydrogenase in complex with co- NADP
Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: aldh1l1, fthfd. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (498 residues) CATH domains: 3.40.605.10 3.40.309.10
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
3rhl
Crystal structure of the e673a/c707a double mutant of thE C- domain of rat 10'formyltetrahydrofolate dehydrogenase in co co-purified NADP
Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: aldh1l1, fthfd. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (498 residues) CATH domains: 3.40.605.10 3.40.309.10
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
3rhm
Crystal structure of the e673q mutant of c-terminal domain o 10'formyltetrahydrofolate dehydrogenase
Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: aldh1l1, fthfd. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (498 residues) CATH domains: 3.40.605.10 3.40.309.10
3rho
Crystal structure of the e673q mutant of c-terminal domain o 10'formyltetrahydrofolate dehydrogenase in complex with nad
Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: aldh1l1, fthfd. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (498 residues) CATH domains: 3.40.605.10 3.40.309.10
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
3rhp
Crystal structure of the c707a mutant of thE C-terminal doma 10'formyltetrahydrofolate dehydrogenase
Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: aldh1l1, fthfd. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (498 residues) CATH domains: 3.40.605.10 3.40.309.10
3rhq
Crystal structure of the c707a mutant of c-terminal domain o 10'formyltetrahydrofolate dehydrogenase in complex with nad
Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: aldh1l1, fthfd. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (498 residues) CATH domains: 3.40.605.10 3.40.309.10
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
3rhr
Crystal structure of the c707a mutant of thE C-terminal doma 10'formyltetrahydrofolate dehydrogenase in complex with nad
Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: aldh1l1, fthfd. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (498 residues) CATH domains: 3.40.605.10 3.40.309.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
4gnz
Crystal structure of the c707s mutant of c-terminal domain o 10'formyltetrahydrofolate dehydrogenase in complex with nad
Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: aldh1l1, fthfd. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (498 residues) CATH domains: 3.40.605.10 3.40.309.10
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
4go0
Crystal structure of the c707s mutant of c-terminal domain o 10'formyltetrahydrofolate dehydrogenase in complex with nad
Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: aldh1l1, fthfd. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (498 residues) CATH domains: 3.40.605.10 3.40.309.10
Bound ligand:   Het Group NDP corresponds to enzyme reactant NADP(+)
4go2
Crystal structure of thE C-terminal domain of 10'formyltetrahydrofolate dehydrogenase in complex with thi
Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: aldh1l1, fthfd. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (498 residues) CATH domains: 3.40.605.10 3.40.309.10
Bound ligand:   Het Group TAP is 95.92% similar to enzyme reactant NADP(+)