_EC 1.4.4.2 Glycine dehydrogenase (aminomethyl-transferring). 6 PDB entries  
EC 1.-.-.- Oxidoreductases. [8,653 PDB entries]
EC 1.4.-.- Acting on the CH-NH(2) group of donors. [357 PDB entries]
EC 1.4.4.- With a disulfide as acceptor. [6 PDB entries]
EC 1.4.4.2 Glycine dehydrogenase (aminomethyl-transferring). [6 PDB entries]    
1wyt

Pathway: Glycine Cleavage System
Reaction: Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L- lysine + CO(2).
 


Glycine
+ [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine
= [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L- lysine
+
CO(2)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Glycine cleavage system P-protein. Glycine decarboxylase. Glycine dehydrogenase (decarboxylating). Glycine-cleavage complex P-protein.
Cofactor(s): Pyridoxal 5'-phosphate.
 

Pyridoxal 5'-phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Comments: A component of the glycine cleavage system, which is composed of four components that only loosely associate: the P protein (EC 1.4.4.2), the T protein (EC 2.1.2.10), the L protein (EC 1.8.1.4) and the lipoyl-bearing H protein. Previously known as glycine synthase.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 6 PDB entries in enzyme class E.C.1.4.4.2

  PDB code Protein
1wyt
Crystal structure of glycine decarboxylase (p-protein) of th cleavage system, in apo form
Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Gene: gcsa. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: gcsb.
Chains: A, B, C, D (437 residues) CATH domains: Unassigned Unassigned
1wyu
Crystal structure of glycine decarboxylase (p-protein) of th cleavage system, in holo form
Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Gene: gcsa. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: gcsb.
Chains: A, B, C, D, E, F, G, H (437 residues) CATH domains: Unassigned Unassigned
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1wyv
Crystal structure of glycine decarboxylase (p-protein) of th cleavage system, in inhibitor-bound form
Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Gene: gcsa. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: gcsb.
Chains: A, B, C, D, E, F, G, H (437 residues) CATH domains: Unassigned Unassigned
Bound ligands:   Het Group AOA is 57.14% similar to enzyme reactant Glycine
  Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
4lgl
Crystal structure of glycine decarboxylase p-protein from synechocystis sp. Pcc 6803, apo form
Source: Synechocystis sp.. Organism_taxid: 1111708. Strain: pcc 6803 / kazusa. Gene: gcvp, slr0293. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (948 residues) CATH domain: Unassigned
Bound ligand:   Het Group TRS is 44.44% similar to enzyme reactant Glycine
4lhc
Crystal structure of synechocystis sp. Pcc 6803 glycine deca (p-protein), holo form with pyridoxal-5'-phosphate and glyc
Source: Synechocystis sp.. Organism_taxid: 1111708. Strain: pcc 6803 / kazusa. Gene: gcvp, slr0293. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (942 residues) CATH domain: Unassigned
Bound ligand:   Het Group GLY corresponds to enzyme reactant Glycine
4lhd
Crystal structure of synechocystis sp. Pcc 6803 glycine deca (p-protein), holo form with pyridoxal-5'-phosphate and glyc closed flexible loop
Source: Synechocystis sp.. Organism_taxid: 1111708. Strain: pcc 6803 / kazusa. Gene: gcvp, slr0293. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (952 residues) CATH domain: Unassigned
Bound ligand:   Het Group GLY corresponds to enzyme reactant Glycine