_EC 1.3.8.4 Isovaleryl-CoA dehydrogenase. 2 PDB entries  
EC 1.-.-.- Oxidoreductases. [8,663 PDB entries]
EC 1.3.-.- Acting on the CH-CH group of donors. [662 PDB entries]
EC 1.3.8.- With a flavin as acceptor. [29 PDB entries]
EC 1.3.8.4 Isovaleryl-CoA dehydrogenase. [2 PDB entries]    
1ivh

Reaction: Isovaleryl-CoA + electron-transfer flavoprotein = 3-methylcrotonyl-CoA + reduced electron-transfer flavoprotein.
 


Isovaleryl-CoA
+ electron-transfer flavoprotein
=
3-methylcrotonyl-CoA
+ reduced electron-transfer flavoprotein
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Cofactor(s): Fad.
 

FAD
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Comments: Pentanoate can act as donor. Formerly Ec 1.3.99.10.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 2 PDB entries in enzyme class E.C.1.3.8.4

  PDB code Protein
1ivh
Structure of human isovaleryl-coa dehydrogenase at 2.6 angstroms resolution: structural basis for substrate specificity
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: liver. Organelle: mitochondria. Gene: ivd. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: the cdna was altered to accommodate
Chains: A, B, C, D (387 residues) CATH domains: 1.10.540.10 2.40.110.10 1.20.140.10
Bound ligands:   Het Group COS is 87.00% similar to enzyme reactant 3-methylbutanoyl-CoA
  Het Group FAD corresponds to enzyme cofactor FAD
4o5m
X-ray crystal structure of isovaleryl-coa dehydrogenase from suis
Source: Brucella suis. Organism_taxid: 204722. Strain: 1330. Gene: ivd, br0020, bs1330_i0020. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (350 residues) CATH domains: 1.10.540.10 2.40.110.10 1.20.140.10