_EC 1.3.3.4 Protoporphyrinogen oxidase. 8 PDB entries  
EC 1.-.-.- Oxidoreductases. [8,663 PDB entries]
EC 1.3.-.- Acting on the CH-CH group of donors. [662 PDB entries]
EC 1.3.3.- With oxygen as acceptor. [42 PDB entries]
EC 1.3.3.4 Protoporphyrinogen oxidase. [8 PDB entries]    
1sez

Pathway: Porphyrin Biosynthesis (later stages)
Reaction: Protoporphyrinogen-IX + 3 O(2) = protoporphyrin-IX + 3 H(2)O(2).
 


Protoporphyrinogen-IX
+
3 × O(2)
=
protoporphyrin-IX
+
3 × H(2)O(2)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Protoporphyrinogen Ix oxidase. Protoporphyrinogenase.
Cofactor(s): Fad.
 

FAD
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Comments: Also slowly oxidizes mesoporphyrinogen Ix.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 8 PDB entries in enzyme class E.C.1.3.3.4

  PDB code Protein
1sez
Crystal structure of protoporphyrinogen ix oxidase
Source: Nicotiana tabacum. Common tobacco. Organism_taxid: 4097. Gene: ppxii, ppox2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (465 residues) CATH domains: 3.50.50.60 3.90.660.20 1.10.3110.10
Bound ligand:   Het Group FAD corresponds to enzyme cofactor FAD
2ivd
Structure of protoporphyrinogen oxidase from myxococcus xanthus with acifluorfen
Source: Myxococcus xanthus. Organism_taxid: 34. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (449 residues) CATH domains: 3.50.50.60 3.90.660.20
Bound ligand:   Het Group FAD corresponds to enzyme cofactor FAD
2ive
Structure of protoporphyrinogen oxidase from myxococcus xanthus
Source: Myxococcus xanthus. Organism_taxid: 34. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (451 residues) CATH domains: 3.50.50.60 3.90.660.20
Bound ligand:   Het Group FAD corresponds to enzyme cofactor FAD
3i6d
Crystal structure of ppo from bacillus subtilis with af
Source: Bacillus subtilis. Organism_taxid: 1423. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (414 residues) CATH domains: 3.50.50.60 3.90.660.20
Bound ligand:   Het Group FAD corresponds to enzyme cofactor FAD
3lov
Crystal structure of putative protoporphyrinogen oxidase (yp_001813199.1) from exiguobacterium sp. 255-15 at 2.06 a
Source: Exiguobacterium sibiricum. Organism_taxid: 262543. Strain: dsm 17290 / jcm 13490 / 255-15. Gene: exig_0701. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (451 residues) CATH domains: 3.50.50.60 3.90.660.20 1.10.3110.10
Bound ligand:   Het Group FAD corresponds to enzyme cofactor FAD
3nks
Structure of human protoporphyrinogen ix oxidase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ppox. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (465 residues) CATH domain: Unassigned
Bound ligand:   Het Group FAD corresponds to enzyme cofactor FAD
4ivm
Structure of human protoporphyrinogen ix oxidase(r59g)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ppox. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: B (464 residues) CATH domain: Unassigned
Bound ligand:   Het Group FAD corresponds to enzyme cofactor FAD
4ivo
Structure of human protoporphyrinogen ix oxidase(r59q)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ppox. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: B (464 residues) CATH domain: Unassigned
Bound ligand:   Het Group FAD corresponds to enzyme cofactor FAD