_EC 1.3.1.45 2'-hydroxyisoflavone reductase. 1 PDB entries  
EC 1.-.-.- Oxidoreductases. [9,068 PDB entries]
EC 1.3.-.- Acting on the CH-CH group of donors. [689 PDB entries]
EC 1.3.1.- With NAD(+) or NADP(+) as acceptor. [363 PDB entries]
EC 1.3.1.45 2'-hydroxyisoflavone reductase. [1 PDB entries]    
2gas

Pathway: Formononetin and Derivatives Biosynthesis
Reaction: Vestitone + NADP(+) = 2'-hydroxyformononetin + Nadph.
 


Vestitone
+
NADP(+)
=
2'-hydroxyformononetin
+
NADPH
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Comments: In the reverse reaction, a 2'-hydroxyisoflavone is reduced to an isoflavanone; 2'-hydroxypseudobaptigenin also acts. Involved in the biosynthesis of the pterocarpin phytoalexins medicarpin and maackiain.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 1 PDB entries in enzyme class E.C.1.3.1.45

  PDB code Protein
2gas
Crystal structure of isoflavone reductase
Source: Medicago sativa. Organism_taxid: 3879. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (307 residues) CATH domains: 3.40.50.720 3.90.25.10