_EC 1.3.1.22 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)). 0 PDB entries  
EC 1.-.-.- Oxidoreductases. [9,199 PDB entries]
EC 1.3.-.- Acting on the CH-CH group of donors. [688 PDB entries]
EC 1.3.1.- With NAD(+) or NADP(+) as acceptor. [363 PDB entries]
EC 1.3.1.22 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)). [-]    

Reaction: A 3-oxo-5-alpha-steroid + NADP(+) = a 3-oxo-Delta(4)-steroid + nadph.
 


3-oxo-5-alpha-steroid
+
NADP(+)
=
3-oxo-Delta(4)-steroid
+
NADPH
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): 3-oxo-5-alpha-steroid 4-dehydrogenase. Cholestenone 5-alpha-reductase.
Comments: The enzyme catalyzes the conversion of assorted 3-oxo-Delta(4) steroids into their corresponding 5-alpha form. Substrates for the mammalian enzyme include testosterone, progesterone, and corticosterone. Substrates for the plant enzyme are brassinosteroids such as campest- 4-en-3-one and (22-alpha)-hydroxy-campest-4-en-3-one. Cf. Ec 1.3.99.5. Formerly Ec 1.3.1.4 and Ec 1.3.1.30.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are no PDB entries in enzyme class E.C.1.3.1.22