_EC 1.22.1.1 Iodotyrosine deiodinase. 5 PDB entries  
EC 1.-.-.- Oxidoreductases. [8,653 PDB entries]
EC 1.22.-.- Acting on halogen in donors. [5 PDB entries]
EC 1.22.1.- With NAD(+) or NADP(+) as acceptor. [5 PDB entries]
EC 1.22.1.1 Iodotyrosine deiodinase. [5 PDB entries]    
3gb5

Reaction: L-tyrosine + 2 NADP(+) + 2 I(-) = 3,5-diiodo-L-tyrosine + 2 Nadph.
 


L-tyrosine
+
2 × NADP(+)
+ 2 × I(-)
=
3,5-diiodo-L-tyrosine
+
2 × NADPH
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Iodotyrosine dehalogenase 1.
Cofactor(s): Fmn.
 

FMN
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Comments: The enzyme activity has only been demonstrated in the direction of 3-deiodination. Present in a transmembrane flavoprotein.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 5 PDB entries in enzyme class E.C.1.22.1.1

  PDB code Protein
3gb5
Crystal structure of mus musculus iodotyrosine deiodinase (i to fmn
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: iyd, dehal1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (185 residues) CATH domain: 3.40.109.10
Bound ligand:   Het Group FMN corresponds to enzyme cofactor FMN
3gfd
Crystal structure of mus musculus iodotyrosine deiodinase (i to fmn and mono-iodotyrosine (mit)
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: dehal1, iyd. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chains: A, B (220 residues) CATH domain: 3.40.109.10
Bound ligands:   Het Group IYR corresponds to enzyme product 3-iodo-L-tyrosine
  Het Group IYR corresponds to enzyme reactant 3-iodo-L-tyrosine
  Het Group FMN corresponds to enzyme cofactor FMN
3gh8
Crystal structure of mus musculus iodotyrosine deiodinase (i to fmn and di-iodotyrosine (dit)
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: dehal1, iyd. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chains: A, B, C, D, E, F, G, H (221 residues) CATH domain: 3.40.109.10
Bound ligands:   Het Group TYI is 93.33% similar to enzyme product 3-iodo-L-tyrosine
  Het Group TYI corresponds to enzyme product 3,5-diiodo-L-tyrosine
  Het Group FMN corresponds to enzyme cofactor FMN
3tnz
Crystal structure of mus musculus iodotyrosine deiodinase (i c239a bound to fmn and mono-iodotyrosine (mit)
Source: Mus musculus. Mouse. Organism_taxid: 10090. Strain: 10090. Gene: dehal1, iyd, iyd-1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (222 residues) CATH domain: 3.40.109.10
Bound ligands:   Het Group IYR corresponds to enzyme product 3-iodo-L-tyrosine
  Het Group IYR corresponds to enzyme reactant 3-iodo-L-tyrosine
  Het Group FMN corresponds to enzyme cofactor FMN
3to0
Crystal structure of mus musculus iodotyrosine deiodinase (i c239a bound to fmn
Source: Mus musculus. Mouse. Organism_taxid: 10090. Strain: 10090. Gene: iyd-1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (184 residues) CATH domain: 3.40.109.10
Bound ligand:   Het Group FMN corresponds to enzyme cofactor FMN