_EC 1.20.4.2 Methylarsonate reductase. 7 PDB entries  
EC 1.-.-.- Oxidoreductases. [8,010 PDB entries]
EC 1.20.-.- Acting on phosphorus or arsenic in donors. [27 PDB entries]
EC 1.20.4.- With disulfide as acceptor. [18 PDB entries]
EC 1.20.4.2 Methylarsonate reductase. [7 PDB entries]    
1eem

Reaction: Methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H(2)O.
 


Methylarsonate
+
2 × glutathione
=
methylarsonite
+
glutathione disulfide
+ H(2)O
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): MMA(V) reductase.
Comments: The product, Me-As(OH)(2) (methylarsonous acid), is biologically methylated by Ec 2.1.1.137 to form cacodylic acid (dimethylarsinic acid). Formerly Ec 1.97.1.7.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 7 PDB entries in enzyme class E.C.1.20.4.2

  PDB code Protein
1eem
Glutathione transferase from homo sapiens
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (237 residues) CATH domains: 3.40.30.10 1.20.1050.10
Bound ligand:   Het Group GSH corresponds to enzyme reactant Methylarsonate
3lfl
Crystal structure of human glutathione transferase omega 1,
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gsto1, gsttlp28. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C (236 residues) CATH domains: 3.40.30.10 1.20.1050.10
Bound ligand:   Het Group GSH corresponds to enzyme reactant Methylarsonate
3q18
Human glutathione transferase o2
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gsto2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (236 residues) CATH domains: 3.40.30.10 1.20.1050.10
3q19
Human glutathione transferase o2
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gsto2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (224 residues) CATH domains: 3.40.30.10 1.20.1050.10
Bound ligand:   Het Group GSH corresponds to enzyme reactant Methylarsonate
3qag
Human glutathione transferase o2 with glutathione -new cryst
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gsto2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (238 residues) CATH domains: 3.40.30.10 1.20.1050.10
Bound ligand:   Het Group GSH corresponds to enzyme reactant Methylarsonate
3vln
Human glutathione transferase o1-1 c32s mutant in complex wi ascorbic acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gsto1, gsttlp28. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (239 residues) CATH domains: 3.40.30.10 1.20.1050.10
4is0
Structural insights into omega-class glutathione transferase snapshot of enzyme reduction and identification of the non- ligandin site.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gsto1, gsttlp28. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (238 residues) CATH domains: 3.40.30.10 1.20.1050.10
Bound ligand:   Het Group GDS corresponds to enzyme product Methylarsonate