_EC 1.20.4.1 Arsenate reductase (glutaredoxin). 16 PDB entries  
EC 1.-.-.- Oxidoreductases. [8,663 PDB entries]
EC 1.20.-.- Acting on phosphorus or arsenic in donors. [32 PDB entries]
EC 1.20.4.- With disulfide as acceptor. [23 PDB entries]
EC 1.20.4.1 Arsenate reductase (glutaredoxin). [16 PDB entries]    
1i9d

Reaction: Arsenate + glutaredoxin = arsenite + glutaredoxin disulfide + H(2)O.
 


Arsenate
+ glutaredoxin
=
arsenite
+ glutaredoxin disulfide
+ H(2)O
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Cofactor(s): Mo cation.
Comments: The glutaredoxins catalyze glutathione-disulfide oxidoreductions and have a redox-active disulfide/dithiol in the active site (-Cys- Pro-Tyr-Cys-) that forms a disulfide bond in the oxidized form. Glutaredoxins have a binding site for glutathione, which is required to reduce them to the dithiol form. Thioredoxins reduced by Nadph and thioredoxin reductase can act as alternative substrates. The enzyme is part of a system for detoxifying arsenate. Although the arsenite formed is more toxic than arsenate, it can be extruded from some bacteria by Ec 3.6.3.16.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 16 PDB entries in enzyme class E.C.1.20.4.1

  PDB code Protein
1i9d
Arsenate reductase from e. Coli
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (138 residues) CATH domain: 3.40.30.10
1j9b
Arsenate reductase+0.4m arsenite from e. Coli
Source: Escherichia coli. Organism_taxid: 562. Plasmid: r773
Chain: A (138 residues) CATH domain: 3.40.30.10
1jzw
Arsenate reductase + sodium arsenate from e. Coli
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (138 residues) CATH domain: 3.40.30.10
1s3c
Arsenate reductase c12s mutant from e. Coli
Source: Escherichia coli. Organism_taxid: 562. Plasmid: r773
Chain: A (138 residues) CATH domain: 3.40.30.10
1s3d
Arsenate reductase r60a mutant from e. Coli
Source: Escherichia coli. Organism_taxid: 562. Plasmid: r773
Chain: A (138 residues) CATH domain: 3.40.30.10
1sd8
Arsenate reductase r60k mutant from e. Coli
Source: Escherichia coli. Organism_taxid: 562. Plasmid: r773
Chain: A (138 residues) CATH domain: 3.40.30.10
1sd9
Arsenate reductase c12s mutant +0.4m arsenate from e. Coli
Source: Escherichia coli. Organism_taxid: 562. Plasmid: r773
Chain: A (138 residues) CATH domain: 3.40.30.10
1sjz
Arsenate reductase r60k mutant +0.4m arsenite from e. Coli
Source: Escherichia coli. Organism_taxid: 562. Plasmid: r773
Chain: A (138 residues) CATH domain: 3.40.30.10
1sk0
Arsenate reductase r60a mutant +0.4m arsenite from e. Coli
Source: Escherichia coli. Organism_taxid: 562. Plasmid: r773
Chain: A (138 residues) CATH domain: 3.40.30.10
1sk1
Arsenate reductase r60k mutant +0.4m arsenate from e. Coli
Source: Escherichia coli. Organism_taxid: 562. Plasmid: r773
Chain: A (138 residues) CATH domain: 3.40.30.10
1sk2
Arsenate reductase r60a mutant +0.4m arsenate from e. Coli
Source: Escherichia coli. Organism_taxid: 562. Plasmid: r773
Chain: A (138 residues) CATH domain: 3.40.30.10
2l17
An arsenate reductase in the reduced state
Source: Synechocystis. Organism_taxid: 1148. Strain: pcc 6803. Gene: arsc, slr0946. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (131 residues) CATH domain: 3.40.50.2300
2l18
An arsenate reductase in the phosphate binding state
Source: Synechocystis. Organism_taxid: 1148. Strain: pcc 6803. Gene: arsc, slr0946. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (131 residues) CATH domain: 3.40.50.2300
2l19
An arsenate reductase in the intermediate state
Source: Synechocystis. Organism_taxid: 1148. Strain: pcc 6803. Gene: arsc, slr0946. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (131 residues) CATH domain: 3.40.50.2300
4kje
Atomic resolution structure of pfgrx1
Source: Plasmodium falciparum. Organism_taxid: 36329. Strain: 3d7. Gene: grx1, pfc0271c. Expressed in: escherichia coli. Expression_system_taxid: 1007065.
Chain: A (106 residues) CATH domain: 3.40.30.10
4kjf
Atomic resolution structure of pfgrx1
Source: Plasmodium falciparum. Organism_taxid: 36329. Strain: 3d7. Gene: grx1, pfc0271c. Expressed in: escherichia coli. Expression_system_taxid: 1007065.
Chain: A (106 residues) CATH domain: 3.40.30.10