_EC 1.2.99.2 Carbon-monoxide dehydrogenase (acceptor). 26 PDB entries  
EC 1.-.-.- Oxidoreductases. [8,663 PDB entries]
EC 1.2.-.- Acting on the aldehyde or oxo group of donors. [499 PDB entries]
EC 1.2.99.- With other acceptors. [37 PDB entries]
EC 1.2.99.2 Carbon-monoxide dehydrogenase (acceptor). [26 PDB entries]    
1ffu

Reaction: Co + H(2)O + a = CO(2) + AH(2).
 


CO
+ H(2)O
+
=
CO(2)
+ AH(2)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Anaerobic carbon monoxide dehydrogenase. Carbon monoxide oxygenase. Carbon-monoxide dehydrogenase.
Cofactor(s): Iron-sulfur; Ni(2+).
 

Iron-sulfur
Ni(2+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Comments: It uses many electron acceptors, including ferredoxin, methyl viologen and benzyl viologen and flavins, but not pyridine nucleotides. Forms part of a membrane-bound multienzyme complex with Ec 1.12.99.6, which catalyzes the overall reaction: Co + H(2)O = CO(2) + H(2).
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 26 PDB entries in enzyme class E.C.1.2.99.2

  PDB code Protein
1ffu
Carbon monoxide dehydrogenase from hydrogenophaga pseudoflava which lacks the mo-pyranopterin moiety of the molybdenum cofactor
Source: Hydrogenophaga pseudoflava. Organism_taxid: 47421. Organism_taxid: 47421
Chains: A, B, C, D, E, F (155 residues) CATH domains: 3.10.20.30 1.10.150.120
1ffv
Carbon monoxide dehydrogenase from hydrogenophaga pseudoflava
Source: Hydrogenophaga pseudoflava. Organism_taxid: 47421. Organism_taxid: 47421
Chains: A, B, C, D, E, F (155 residues) CATH domains: 3.10.20.30 1.10.150.120
1jjy
Crystal structure of a ni-containing carbon monoxide dehydrogenase from carboxydothermus hydrogenoformans
Source: Carboxydothermus hydrogenoformans. Bacteria
Chain: A (633 residues) CATH domains: 3.40.50.2030 3.40.50.2030 1.20.1270.30
1jqk
Crystal structure of carbon monoxide dehydrogenase from rhodospirillum rubrum
Source: Rhodospirillum rubrum. Organism_taxid: 1085. Other_details: coos gene
Chains: A, B, C, D, E, F (610 residues) CATH domains: 3.40.50.2030 3.40.50.2030 1.20.1270.30
1mjg
Crystal structure of bifunctional carbon monoxide dehydrogenase/acetyl-coa synthase(codh/acs) from moorella thermoacetica (f. Clostridium thermoaceticum)
Source: Moorella thermoacetica. Organism_taxid: 1525. Organism_taxid: 1525
Chains: A, B, C, D (672 residues) CATH domains: 3.40.50.2030 3.40.50.2030 1.20.1270.30
Bound ligand:   Het Group ACT is 66.00% similar to enzyme reactant CO
1n5w
Crystal structure of the cu,mo-co dehydrogenase (codh); oxid
Source: Oligotropha carboxidovorans. Organism_taxid: 504832. Strain: om5. Strain: om5
Chains: A, B, C, D, E, F (161 residues) CATH domains: 3.10.20.30 1.10.150.120
1n60
Crystal structure of the cu,mo-co dehydrogenase (codh); cyan inactivated form
Source: Oligotropha carboxidovorans. Organism_taxid: 504832. Strain: om5. Strain: om5
Chains: A, B, C, D, E, F (161 residues) CATH domains: 3.10.20.30 1.10.150.120
1n61
Crystal structure of the cu,mo-co dehydrogenase (codh); dith reduced state
Source: Oligotropha carboxidovorans. Organism_taxid: 504832. Strain: om5. Strain: om5
Chains: A, B, C, D, E, F (161 residues) CATH domains: 3.10.20.30 1.10.150.120
1n62
Crystal structure of the mo,cu-co dehydrogenase (codh), n- butylisocyanide-bound state
Source: Oligotropha carboxidovorans. Organism_taxid: 504832. Strain: om5. Strain: om5
Chains: A, B, C, D, E, F (161 residues) CATH domains: 3.10.20.30 1.10.150.120
1n63
Crystal structure of the cu,mo-co dehydrogenase (codh); carb monoxide reduced state
Source: Oligotropha carboxidovorans. Organism_taxid: 504832. Strain: om5. Strain: om5
Chains: A, B, C, D, E, F (160 residues) CATH domains: 3.10.20.30 1.10.150.120
1oao
Nizn[fe4s4] and nini[fe4s4] clusters in closed and open alpha subunits of acetyl-coa synthase/carbon monoxide dehydrogenase
Source: Moorella thermoacetica. Organism_taxid: 1525. Organism_taxid: 1525
Chains: A, B (673 residues) CATH domains: 3.40.50.2030 3.40.50.2030 1.20.1270.30
Bound ligands:   Het Group FOR corresponds to enzyme reactant CO
  Het Group BCT is 75.00% similar to enzyme product CO(2)
1qj2
Co dehydrogenase from oligotropha carboxidovorans
Source: Pseudomonas carboxydovorans. Plasmid: phcg3. Gene: coxm. Gene: coxs. Gene: coxl
Chains: A, B, C, G, H, I (159 residues) CATH domains: 3.10.20.30 1.10.150.120
1su6
Carbon monoxide dehydrogenase from carboxydothermus hydrogen co reduced state
Source: Carboxydothermus hydrogenoformans. Organism_taxid: 129958
Chain: A (633 residues) CATH domains: 1.20.1270.30 3.40.50.2030 3.40.50.2030
1su7
Carbon monoxide dehydrogenase from carboxydothermus hydrogen dtt reduced state
Source: Carboxydothermus hydrogenoformans. Organism_taxid: 129958
Chain: A (633 residues) CATH domains: 1.20.1270.30 3.40.50.2030 3.40.50.2030
1su8
Carbon monoxide induced decomposition of the active site [ni cluster of co dehydrogenase
Source: Carboxydothermus hydrogenoformans. Organism_taxid: 129958
Chain: A (633 residues) CATH domains: 1.20.1270.30 3.40.50.2030 3.40.50.2030
1suf
Carbon monoxide dehydrogenase from carboxydothermus hydrogen inactive state
Source: Carboxydothermus hydrogenoformans. Organism_taxid: 129958
Chain: A (633 residues) CATH domains: 1.20.1270.30 3.40.50.2030 3.40.50.2030
1zxi
Reconstituted co dehydrogenase from oligotropha carboxidovor
Source: Oligotropha carboxidovorans. Organism_taxid: 504832. Strain: om5. Strain: om5
Chains: A, B, C, D, E, F (161 residues) CATH domains: 3.10.20.30 1.10.150.120
2yiv
Ni,fe-codh with n-butylisocyanate state
Source: Carboxydothermus hydrogenoformans. Organism_taxid: 129958. Strain: z-2091. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta.
Chain: X (635 residues) CATH domains: 1.20.1270.30 3.40.50.2030 3.40.50.2030
2z8y
Xenon-bound structure of bifunctional carbon monoxide dehydrogenase/acetyl-coa synthase(codh/acs) from moorella thermoacetica
Source: Moorella thermoacetica. Organism_taxid: 1525. Organism_taxid: 1525
Chains: A, B, C, D (673 residues) CATH domains: 1.20.1270.30 3.40.50.2030 3.40.50.2030
3b51
Ni,fe-codh-600 mv state
Source: Carboxydothermus hydrogenoformans z- 2901. Organism_taxid: 246194. Strain: z-2901 / dsm 6008. Gene: coos2, coosii. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: X (633 residues) CATH domains: 1.20.1270.30 3.40.50.2030 3.40.50.2030
3b52
Ni,fe-codh-600 mv state + co2
Source: Carboxydothermus hydrogenoformans z- 2901. Organism_taxid: 246194. Strain: z-2901 / dsm 6008. Gene: coos2, coosii. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: X (633 residues) CATH domains: 1.20.1270.30 3.40.50.2030 3.40.50.2030
Bound ligand:   Het Group CO2 corresponds to enzyme product CO(2)
3b53
Ni,fe-codh-320 mv state
Source: Carboxydothermus hydrogenoformans z- 2901. Organism_taxid: 246194. Strain: z-2901 / dsm 6008. Gene: coos2, coosii. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: X (633 residues) CATH domains: 1.20.1270.30 3.40.50.2030 3.40.50.2030
3cf4
Structure of the codh component of the m. Barkeri acds compl
Source: Methanosarcina barkeri. Organism_taxid: 2208. Strain: ms (dsm800). Other_details: gene cdha. Other_details: gene cdhb
Chain: A (766 residues) CATH domains: Unassigned Unassigned Unassigned
Bound ligands:   Het Group CMO corresponds to enzyme reactant CO
  Het Group ACY is 75.00% similar to enzyme product CO(2)
3i01
Native structure of bifunctional carbon monoxide dehydrogena coa synthase from moorella thermoacetica, water-bound c-clu
Source: Moorella thermoacetica. Clostridium thermoaceticum. Organism_taxid: 1525. Organism_taxid: 1525
Chains: A, B, C, D (673 residues) CATH domains: 1.20.1270.30 3.40.50.2030 3.40.50.2030
Bound ligand:   Het Group ACT is 66.67% similar to enzyme reactant CO
3i04
Cyanide-bound structure of bifunctional carbon monoxide dehydrogenase/acetyl-coa synthase from moorella thermoaceti cyanide-bound c-cluster
Source: Moorella thermoacetica. Clostridium thermoaceticum. Organism_taxid: 1525. Organism_taxid: 1525
Chains: A, B, C, D (673 residues) CATH domains: 1.20.1270.30 3.40.50.2030 3.40.50.2030
Bound ligand:   Het Group ACT is 66.67% similar to enzyme reactant CO
3i39
Ni,fe-codh-320 mv+cn state
Source: Carboxydothermus hydrogenoformans. Organism_taxid: 246194. Strain: z-2901. Gene: chy_0085, coos2, coosii. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: X (635 residues) CATH domains: 1.20.1270.30 3.40.50.2030 3.40.50.2030