_EC 1.2.7.1 Pyruvate synthase. 1 PDB entries  
EC 1.-.-.- Oxidoreductases. [8,653 PDB entries]
EC 1.2.-.- Acting on the aldehyde or oxo group of donors. [500 PDB entries]
EC 1.2.7.- With an iron-sulfur protein as acceptor. [7 PDB entries]
EC 1.2.7.1 Pyruvate synthase. [1 PDB entries]    
2raa

Reaction: Pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO(2) + 2 reduced ferredoxin + 2 H(+).
 


Pyruvate
+
CoA
+ 2 × oxidized ferredoxin
=
acetyl-CoA
+
CO(2)
+ 2 × reduced ferredoxin
+ 2 × H(+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): 2-oxobutyrate synthase. 2-oxobutyrate-ferredoxin oxidoreductase. Alpha-ketobutyrate synthase. Alpha-ketobutyrate-ferredoxin oxidoreductase. Pyruvate oxidoreductase. Pyruvate synthetase. Pyruvic-ferredoxin oxidoreductase.
Cofactor(s): Iron-sulfur; Thiamine diphosphate.
 

Iron-sulfur

Thiamine diphosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Comments: The enzyme also decarboxylates 2-oxobutanoate with lower efficiency, but shows no activity with 2-oxoglutarate. This enzyme is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity. For examples of other members of this family, see Ec 1.2.7.3 and Ec 1.2.7.7.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 1 PDB entries in enzyme class E.C.1.2.7.1

  PDB code Protein
2raa
Crystal structure of pyruvate oxidoreductase subunit porc (e (tm0015) from thermotoga maritima at 2.12 a resolution
Source: Thermotoga maritima msb8. Organism_taxid: 243274. Strain: msb8, dsm 3109, jcm 10099. Atcc: 43589. Gene: tm0015, porc, porg. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (178 residues) CATH domain: 3.40.920.10