_EC 1.2.1.19 Aminobutyraldehyde dehydrogenase. 4 PDB entries  
EC 1.-.-.- Oxidoreductases. [8,653 PDB entries]
EC 1.2.-.- Acting on the aldehyde or oxo group of donors. [500 PDB entries]
EC 1.2.1.- With NAD(+) or NADP(+) as acceptor. [369 PDB entries]
EC 1.2.1.19 Aminobutyraldehyde dehydrogenase. [4 PDB entries]    
1wnb

Reaction: 4-aminobutanal + NAD(+) + H(2)O = 4-aminobutanoate + Nadh.
 


4-aminobutanal
+
NAD(+)
+ H(2)O
=
4-aminobutanoate
+
NADH
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): 1-pyrroline dehydrogenase. 4-aminobutanal dehydrogenase. Abaldh. Gamma-guanidinobutyraldehyde dehydrogenase.
Comments: The enzyme from some species exhibits broad substrate specificity and has a marked preference for straight-chain aldehydes (up to 7 carbon atoms) as substrates. The plant enzyme also acts on 4-guanidinobutanal (cf. Ec 1.2.1.54). As 1-pyrroline and 4-aminobutanal are in equilibrium and can be interconverted spontaneously, 1-pyrroline may act as the starting substrate. Formerly Ec 1.5.1.35.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 4 PDB entries in enzyme class E.C.1.2.1.19

  PDB code Protein
1wnb
Escherichia coli ydcw gene product is a medium-chain aldehyd dehydrogenase (complexed with nadh and betaine aldehyde)
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B, C, D (474 residues) CATH domains: 3.40.605.10 3.40.309.10
Bound ligand:   Het Group NAI corresponds to enzyme reactant NAD(+)
1wnd
Escherichia coli ydcw gene product is a medium-chain aldehyd dehydrogenase as determined by kinetics and crystal stuctur
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B, C, D (474 residues) CATH domains: 3.40.605.10 3.40.309.10
3iwk
Crystal structure of aminoaldehyde dehydrogenase 1 from pisu (psamadh1)
Source: Pisum sativum. Garden pea. Organism_taxid: 3888. Gene: amadh1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F, G, H, I, J, K, L (496 residues) CATH domains: 3.40.605.10 3.40.309.10
Bound ligands:   Het Group MRD is 55.56% similar to enzyme reactant 4-aminobutanal
  Het Group NAD corresponds to enzyme reactant NAD(+)
4i8p
Crystal structure of aminoaldehyde dehydrogenase 1a from zea (zmamadh1a)
Source: Zea mays. Maize. Organism_taxid: 4577. Gene: amadh1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (500 residues) CATH domains: 3.40.605.10 3.40.309.10
Bound ligands:   Het Group GOL is 50.00% similar to enzyme reactant 4-aminobutanal
  Het Group NAD corresponds to enzyme reactant NAD(+)