_EC 1.2.1.10 Acetaldehyde dehydrogenase (acetylating). 5 PDB entries  
EC 1.-.-.- Oxidoreductases. [8,663 PDB entries]
EC 1.2.-.- Acting on the aldehyde or oxo group of donors. [499 PDB entries]
EC 1.2.1.- With NAD(+) or NADP(+) as acceptor. [369 PDB entries]
EC 1.2.1.10 Acetaldehyde dehydrogenase (acetylating). [5 PDB entries]    
1nvm

Reaction: Acetaldehyde + CoA + NAD(+) = acetyl-CoA + Nadh.
 


Acetaldehyde
+
CoA
+
NAD(+)
=
acetyl-CoA
+
NADH
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Acylating acetaldehyde dehydrogenase. Aldehyde dehydrogenase (acylating).
Comments: Also acts, more slowly, on glycolaldehyde, propanal and butanal. In several bacterial species this enzyme forms a bifunctional complex with Ec 4.1.3.39. The enzymes from the bacteria Burkholderia xenovorans and Thermus thermophilus also perform the reaction of Ec 1.2.1.87. Involved in the meta-cleavage pathway for the degradation of phenols, methylphenols and catechols. NADP(+) can replace NAD(+) but the rate of reaction is much slower.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 5 PDB entries in enzyme class E.C.1.2.1.10

  PDB code Protein
1nvm
Crystal structure of a bifunctional aldolase-dehydrogenase : sequestering a reactive and volatile intermediate
Source: Pseudomonas sp.. Organism_taxid: 79676. Strain: cf600. Gene: dmpg. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: dmpf.
Chains: B, D, F, H (312 residues) CATH domains: 3.40.50.720 3.30.360.10
Bound ligands:   Het Group OXL is 50.00% similar to enzyme reactant acetaldehyde
  Het Group NAD corresponds to enzyme reactant NAD(+)
3zdr
Structure of the alcohol dehydrogenase (adh) domain of a bifunctional adhe dehydrogenase from geobacillus thermoglucosidasius ncimb 11955
Source: Geobacillus thermoglucosidasius. Organism_taxid: 1426. Strain: tm242. Atcc: 43742. Expressed in: escherichia coli. Expression_system_taxid: 511693. Other_details: the ncimb 11955 strain engineered by tmo ren ltd to increase ethanol production.
Chain: A (403 residues) CATH domains: 3.40.50.1970 1.20.1090.10
Bound ligand:   Het Group GOL is 50.00% similar to enzyme reactant acetaldehyde
4jn6
Crystal structure of the aldolase-dehydrogenase complex from mycobacterium tuberculosis hrv37
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: hrv37. Gene: rv3534c, mt3638. Expressed in: rhodococcus jostii. Expression_system_taxid: 132919. Gene: mhpf, rv3535c, mt3639.
Chains: B, D (296 residues) CATH domains: 3.40.50.720 3.30.360.10
Bound ligand:   Het Group OXL is 50.00% similar to enzyme reactant acetaldehyde
4lrs
Crystal and solution structures of the bifunctional enzyme (aldolase/aldehyde dehydrogenase) from thermomonospora curv reveal a cofactor-binding domain motion during NAD+ and coa accommodation whithin the shared cofactor-binding site
Source: Thermomonospora curvata. Organism_taxid: 471852. Strain: dsm 43183. Gene: tcur_0536. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: tcur_0535. Organism_taxid: 2020.
Chain: B (294 residues) CATH domains: 3.40.50.720 3.30.360.10
Bound ligands:   Het Group ALA is 60.00% similar to enzyme reactant acetaldehyde
  Het Group NAD corresponds to enzyme reactant NAD(+)
4lrt
Crystal and solution structures of the bifunctional enzyme (aldolase/aldehyde dehydrogenase) from thermomonospora curv reveal a cofactor-binding domain motion during NAD+ and coa accommodation whithin the shared cofactor-binding site
Source: Thermomonospora curvata. Organism_taxid: 471852. Strain: dsm 43183. Gene: tcur_0536. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: tcur_0535.
Chains: B, D (295 residues) CATH domains: 3.40.50.720 3.30.360.10
Bound ligands:   Het Group PYR is 50.00% similar to enzyme reactant acetaldehyde
  Het Group COA corresponds to enzyme reactant CoA