_EC 1.2.1.- With NAD(+) or NADP(+) as acceptor. 368 PDB entries  
EC 1.-.-.- Oxidoreductases. [8,840 PDB entries]
EC 1.2.-.- Acting on the aldehyde or oxo group of donors. [511 PDB entries]
EC 1.2.1.- With NAD(+) or NADP(+) as acceptor. [368 PDB entries]    
EC 1.2.1.1 Transferred entry: 1.1.1.284 and 4.4.1.22. [-]
EC 1.2.1.2 Formate dehydrogenase. [16 PDB entries]
EC 1.2.1.3 Aldehyde dehydrogenase (NAD(+)). [51 PDB entries]
EC 1.2.1.4 Aldehyde dehydrogenase (NADP(+)). [3 PDB entries]
EC 1.2.1.5 Aldehyde dehydrogenase (NAD(P)(+)). [8 PDB entries]
EC 1.2.1.6 Deleted entry. [-]
EC 1.2.1.7 Benzaldehyde dehydrogenase (NADP(+)). [2 PDB entries]
EC 1.2.1.8 Betaine-aldehyde dehydrogenase. [22 PDB entries]
EC 1.2.1.9 Glyceraldehyde-3-phosphate dehydrogenase (NADP(+)). [17 PDB entries]
EC 1.2.1.10 Acetaldehyde dehydrogenase (acetylating). [4 PDB entries]
EC 1.2.1.11 Aspartate-semialdehyde dehydrogenase. [43 PDB entries]
EC 1.2.1.12 Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating). [84 PDB entries]
EC 1.2.1.13 Glyceraldehyde-3-phosphate dehydrogenase (NADP(+)) (phosphorylating). [11 PDB entries]
EC 1.2.1.14 Transferred entry: 1.1.1.205. [-]
EC 1.2.1.15 Malonate-semialdehyde dehydrogenase. [-]
EC 1.2.1.16 Succinate-semialdehyde dehydrogenase (NAD(P)(+)). [5 PDB entries]
EC 1.2.1.17 Glyoxylate dehydrogenase (acylating). [-]
EC 1.2.1.18 Malonate-semialdehyde dehydrogenase (acetylating). [1 PDB entries]
EC 1.2.1.19 Aminobutyraldehyde dehydrogenase. [4 PDB entries]
EC 1.2.1.20 Glutarate-semialdehyde dehydrogenase. [-]
EC 1.2.1.21 Glycolaldehyde dehydrogenase. [4 PDB entries]
EC 1.2.1.22 Lactaldehyde dehydrogenase. [6 PDB entries]
EC 1.2.1.23 2-oxoaldehyde dehydrogenase (NAD(+)). [-]
EC 1.2.1.24 Succinate-semialdehyde dehydrogenase (NAD(+)). [5 PDB entries]
EC 1.2.1.25 2-oxoisovalerate dehydrogenase (acylating). [-]
EC 1.2.1.26 2,5-dioxovalerate dehydrogenase. [-]
EC 1.2.1.27 Methylmalonate-semialdehyde dehydrogenase (CoA acylating). [3 PDB entries]
EC 1.2.1.28 Benzaldehyde dehydrogenase (NAD(+)). [3 PDB entries]
EC 1.2.1.29 Aryl-aldehyde dehydrogenase. [-]
EC 1.2.1.30 Aryl-aldehyde dehydrogenase (NADP(+)). [-]
EC 1.2.1.31 L-aminoadipate-semialdehyde dehydrogenase. [1 PDB entries]
EC 1.2.1.32 Aminomuconate-semialdehyde dehydrogenase. [-]
EC 1.2.1.33 (R)-dehydropantoate dehydrogenase. [-]
EC 1.2.1.34 Transferred entry: 1.1.1.131. [-]
EC 1.2.1.35 Transferred entry: 1.1.1.203. [-]
EC 1.2.1.36 Retinal dehydrogenase. [2 PDB entries]
EC 1.2.1.37 Transferred entry: 1.17.1.4. [-]
EC 1.2.1.38 N-acetyl-gamma-glutamyl-phosphate reductase. [15 PDB entries]
EC 1.2.1.39 Phenylacetaldehyde dehydrogenase. [1 PDB entries]
EC 1.2.1.40 Deleted entry. [-]
EC 1.2.1.41 Glutamate-5-semialdehyde dehydrogenase. [4 PDB entries]
EC 1.2.1.42 Hexadecanal dehydrogenase (acylating). [-]
EC 1.2.1.43 Formate dehydrogenase (NADP(+)). [-]
EC 1.2.1.44 Cinnamoyl-CoA reductase. [-]
EC 1.2.1.45 Transferred entry: 1.1.1.312. [-]
EC 1.2.1.46 Formaldehyde dehydrogenase. [1 PDB entries]
EC 1.2.1.47 4-trimethylammoniobutyraldehyde dehydrogenase. [-]
EC 1.2.1.48 Long-chain-aldehyde dehydrogenase. [-]
EC 1.2.1.49 2-oxoaldehyde dehydrogenase (NADP(+)). [-]
EC 1.2.1.50 Long-chain-fatty-acyl-CoA reductase. [-]
EC 1.2.1.51 Pyruvate dehydrogenase (NADP(+)). [-]
EC 1.2.1.52 Oxoglutarate dehydrogenase (NADP(+)). [-]
EC 1.2.1.53 4-hydroxyphenylacetaldehyde dehydrogenase. [-]
EC 1.2.1.54 Gamma-guanidinobutyraldehyde dehydrogenase. [-]
EC 1.2.1.55 Transferred entry: 1.1.1.279. [-]
EC 1.2.1.56 Transferred entry: 1.1.1.280. [-]
EC 1.2.1.57 Butanal dehydrogenase. [-]
EC 1.2.1.58 Phenylglyoxylate dehydrogenase (acylating). [-]
EC 1.2.1.59 Glyceraldehyde-3-phosphate dehydrogenase (NAD(P)(+)) (phosphorylating). [4 PDB entries]
EC 1.2.1.60 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase. [-]
EC 1.2.1.61 4-hydroxymuconic-semialdehyde dehydrogenase. [-]
EC 1.2.1.62 4-formylbenzenesulfonate dehydrogenase. [-]
EC 1.2.1.63 6-oxohexanoate dehydrogenase. [-]
EC 1.2.1.64 4-hydroxybenzaldehyde dehydrogenase. [-]
EC 1.2.1.65 Salicylaldehyde dehydrogenase. [-]
EC 1.2.1.66 Transferred entry: 1.1.1.306. [-]
EC 1.2.1.67 Vanillin dehydrogenase. [-]
EC 1.2.1.68 Coniferyl-aldehyde dehydrogenase. [-]
EC 1.2.1.69 Fluoroacetaldehyde dehydrogenase. [-]
EC 1.2.1.70 Glutamyl-tRNA reductase. [3 PDB entries]
EC 1.2.1.71 Succinylglutamate-semialdehyde dehydrogenase. [2 PDB entries]
EC 1.2.1.72 Erythrose-4-phosphate dehydrogenase. [3 PDB entries]
EC 1.2.1.73 Sulfoacetaldehyde dehydrogenase. [-]
EC 1.2.1.74 Abieta-7,13-dien-18-al dehydrogenase. [-]
EC 1.2.1.75 Malonyl CoA reductase (malonate semialdehyde-forming). [3 PDB entries]
EC 1.2.1.76 Succinate-semialdehyde dehydrogenase (acetylating). [-]
EC 1.2.1.77 3,4-dehydroadipyl-CoA semialdehyde dehydrogenase (NADP(+)). [-]
EC 1.2.1.78 2-formylbenzoate dehydrogenase. [-]
EC 1.2.1.79 Succinate-semialdehyde dehydrogenase (NADP(+)). [1 PDB entries]
EC 1.2.1.80 Long-chain acyl-[acyl-carrier-protein] reductase. [-]
EC 1.2.1.81 Sulfoacetaldehyde dehydrogenase (acylating). [-]
EC 1.2.1.82 Beta-apo-4'-carotenal oxygenase. [-]
EC 1.2.1.83 3-succinoylsemialdehyde-pyridine dehydrogenase. [-]
EC 1.2.1.84 Alcohol-forming fatty acyl-CoA reductase. [-]
EC 1.2.1.85 2-hydroxymuconate-6-semialdehyde dehydrogenase. [-]
EC 1.2.1.86 Geranial dehydrogenase. [-]
EC 1.2.1.87 Propanal dehydrogenase (CoA-propanoylating). [-]
EC 1.2.1.88 L-glutamate gamma-semialdehyde dehydrogenase. [36 PDB entries]
EC 1.2.1.89 D-glyceraldehyde dehydrogenase (NADP(+)). [-]
EC 1.2.1.n1 Transferred entry: 1.2.1.77. [-]
EC 1.2.1.n2 Fatty acyl-CoA reductase. [-]
EC 1.2.1.n3 Transferred entry: 1.2.1.86. [-]

[-] signifies that there are no PDB entries for the given enzyme subclass