_EC 1.17.7.1 (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase. 4 PDB entries  
EC 1.-.-.- Oxidoreductases. [7,297 PDB entries]
EC 1.17.-.- Acting on Ch or CH(2) groups. [218 PDB entries]
EC 1.17.7.- With an iron-sulfur protein as acceptor. [4 PDB entries]
EC 1.17.7.1 (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase. [4 PDB entries]    
2y0f

Reaction: (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H(2)O + 2 oxidized ferredoxin = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + 2 reduced ferredoxin.
 


(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate
+ H(2)O
+ 2 × oxidized ferredoxin
=
2-C-methyl-D-erythritol 2,4-cyclodiphosphate
+ 2 × reduced ferredoxin
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase. 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase.
Cofactor(s): Iron-sulfur.
 

Iron-sulfur
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Comments: Forms, in the reverse direction, part of an alternative non- mevalonate pathway for isoprenoid biosynthesis that is found in most bacteria and in plant chloroplasts. The enzyme from the plant Arabidopsis thaliana is active with photoreduced 5-deazaflavin but not with the flavodoxin/flavodoxin reductase/Nadph system that can be used as an electron donor by Escherichia coli. Metabolites derived from isoprenoids play important roles in systems such as electron transport, photosynthesis, plant defense responses, hormonal regulation of development and membrane fluidity.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 4 PDB entries in enzyme class E.C.1.17.7.1

  PDB code Protein
2y0f
Structure of gcpe (ispg) from thermus thermophilus hb27
Source: Thermus thermophilus. Organism_taxid: 262724. Strain: hb27. Atcc: baa-163. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (403 residues) CATH domains: Unassigned Unassigned
3noy
Crystal structure of ispg (gcpe)
Source: Aquifex aeolicus. Organism_taxid: 63363. Gene: aq_1540, gcpe, ispg. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (349 residues) CATH domains: Unassigned Unassigned
4g9p
Structure of the gcpe-mecpp (ispg) complex from thermus ther
Source: Thermus thermophilus. Organism_taxid: 262724. Strain: hb27 / atcc baa-163 / dsm 7039. Gene: gcpe, ispg, tt_c1677. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (405 residues) CATH domains: Unassigned Unassigned
Bound ligand:   Het Group CDI corresponds to enzyme product 2-C-methyl-D-erythritol
4mwa
1.85 angstrom crystal structure of gcpe protein from bacillu anthracis
Source: Bacillus anthracis. Anthrax,anthrax bacterium. Organism_taxid: 260799. Strain: sterne. Gene: bas4180, ba_4502, gbaa_4502, gcpe, ispg. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F, G, H (261 residues) CATH domain: Unassigned