_EC 1.17.3.2 Xanthine oxidase. 29 PDB entries  
EC 1.-.-.- Oxidoreductases. [8,663 PDB entries]
EC 1.17.-.- Acting on Ch or CH(2) groups. [263 PDB entries]
EC 1.17.3.- With oxygen as acceptor. [29 PDB entries]
EC 1.17.3.2 Xanthine oxidase. [29 PDB entries]    
1fiq

Pathway: AMP Catabolism
Reaction: Xanthine + H(2)O + O(2) = urate + H(2)O(2).
 


Xanthine
+ H(2)O
+
O(2)
=
urate
+
H(2)O(2)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Hypoxanthine oxidase. Hypoxanthine-xanthine oxidase. Schardinger enzyme. Xanthine oxidoreductase.
Cofactor(s): FAD; Iron-sulfur; Molybdopterin.
 

FAD

Iron-sulfur

Molybdopterin
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Comments: Also oxidizes hypoxanthine, some other purines and pterins, and aldehydes, but is distinct from Ec 1.2.3.1. Under some conditions the product is mainly superoxide rather than peroxide: R-H + H(2)O + 2 O(2) = Roh + 2 O(2)(.-) + 2 H(+). The mammallian enzyme predominantly exists as an NAD-dependent dehydrogenase (EC 1.17.1.4). During purification the enzyme is largely converted to the O(2)- dependent xanthine oxidase form (EC 1.17.3.2). The conversion can be triggered by several mechanisms, including the oxidation of cysteine thiols to form disulfide bonds (which can be
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 29 PDB entries in enzyme class E.C.1.17.3.2

  PDB code Protein
1fiq
Crystal structure of xanthine oxidase from bovine milk
Source: Bos taurus. Cattle. Organism_taxid: 9913. Secretion: milk. Secretion: milk
Chains: A, B, C (164 residues) CATH domains: 3.10.20.30 1.10.150.120
Bound ligands:   Het Group FAD corresponds to enzyme cofactor FAD
  Het Group MTE corresponds to enzyme cofactor Molybdopterin
1fo4
Crystal structure of xanthine dehydrogenase isolated from bo
Source: Bos taurus. Cattle. Organism_taxid: 9913. Secretion: milk
Chains: A, B (1299 residues) CATH domains: 3.10.20.30 1.10.150.120 3.30.43.10 3.30.465.10 3.30.390.50 3.30.365.10 3.90.1170.50 3.30.365.10 3.30.365.10 3.30.365.10
Bound ligands:   Het Group FAD corresponds to enzyme cofactor FAD
  Het Group MTE corresponds to enzyme cofactor Molybdopterin
1n5x
Xanthine dehydrogenase from bovine milk with inhibitor tei-6
Source: Bos taurus. Cattle. Organism_taxid: 9913. Secretion: milk
Chains: A, B (1290 residues) CATH domains: 3.10.20.30 1.10.150.120 Unassigned 3.30.465.10 3.30.390.50 3.30.365.10 3.90.1170.50 3.30.365.10 3.30.365.10 3.30.365.10
Bound ligands:   Het Group FAD corresponds to enzyme cofactor FAD
  Het Group MTE corresponds to enzyme cofactor Molybdopterin
1v97
Crystal structure of bovine milk xanthine dehydrogenase fyx- form
Source: Bos taurus. Cattle. Organism_taxid: 9913
Chains: A, B (1298 residues) CATH domains: 3.10.20.30 1.10.150.120 Unassigned 3.30.465.10 3.30.390.50 3.30.365.10 3.90.1170.50 3.30.365.10 3.30.365.10 3.30.365.10
Bound ligands:   Het Group FAD corresponds to enzyme cofactor FAD
  Het Group MTE corresponds to enzyme cofactor Molybdopterin
1vdv
Bovine milk xanthine dehydrogenase y-700 bound form
Source: Bos taurus. Cattle. Organism_taxid: 9913. Secretion: milk
Chains: A, B (1299 residues) CATH domains: 3.10.20.30 1.10.150.120 Unassigned 3.30.465.10 3.30.390.50 3.30.365.10 3.90.1170.50 3.30.365.10 3.30.365.10 3.30.365.10
Bound ligands:   Het Group FAD corresponds to enzyme cofactor FAD
  Het Group MTE corresponds to enzyme cofactor Molybdopterin
1wyg
Crystal structure of a rat xanthine dehydrogenase triple mut (c535a, c992r and c1324s)
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chain: A (1297 residues) CATH domains: 3.10.20.30 1.10.150.120 Unassigned Unassigned 3.30.390.50 3.30.365.10 3.90.1170.50 3.30.365.10 3.30.365.10 3.30.365.10
Bound ligand:   Het Group FAD corresponds to enzyme cofactor FAD
2ckj
Human milk xanthine oxidoreductase
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: breast milk. Other_details: milk kindly donated by mothers at the intensive care baby units at the bristol royal infirmary and southmead hospital, bristol, uk
Chains: A, B, C, D (1264 residues) CATH domain: Unassigned
Bound ligand:   Het Group FAD corresponds to enzyme cofactor FAD
2e1q
Crystal structure of human xanthine oxidoreductase mutant, g
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (1307 residues)
Bound ligands:   Het Group FAD corresponds to enzyme cofactor FAD
  Het Group MTE corresponds to enzyme cofactor Molybdopterin
2e3t
Crystal structure of rat xanthine oxidoreductase mutant (w33 f336l)
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chains: A, B (1291 residues)
Bound ligands:   Het Group URC corresponds to enzyme product Urate
  Het Group FAD corresponds to enzyme cofactor FAD
3am9
Complex of bovine xanthine dehydrogenase and trihydroxy fyx-
Source: Bos taurus. Bovine. Organism_taxid: 9913
Chains: A, B (1293 residues)
Bound ligands:   Het Group FAD corresponds to enzyme cofactor FAD
  Het Group MTE corresponds to enzyme cofactor Molybdopterin
3amz
Bovine xanthine oxidoreductase urate bound form
Source: Bos taurus. Bovine. Organism_taxid: 9913
Chains: A, B (1291 residues)
Bound ligands:   Het Group URC corresponds to enzyme product Urate
  Het Group FAD corresponds to enzyme cofactor FAD
  Het Group MTE corresponds to enzyme cofactor Molybdopterin
3an1
Crystal structure of rat d428a mutant, urate bound form
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (1299 residues)
Bound ligands:   Het Group URC corresponds to enzyme product Urate
  Het Group FAD corresponds to enzyme cofactor FAD
3ax7
Bovine xanthine oxidase, protease cleaved form
Source: Bos taurus. Bovine. Organism_taxid: 9913
Chains: A, B (1225 residues)
3ax9
Bovine xanthine oxidase, protease cleaved form
Source: Bos taurus. Bovine. Organism_taxid: 9913
Chains: A, B (1225 residues)
Bound ligands:   Het Group FAD corresponds to enzyme cofactor FAD
  Het Group XAX is 85.71% similar to enzyme cofactor Molybdopterin
3b9j
Structure of xanthine oxidase with 2-hydroxy-6-methylpurine
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organism_taxid: 9913
Chains: A, B, C, I, J, K (162 residues) CATH domains: 3.10.20.30 1.10.150.120
Bound ligands:   Het Group FAD corresponds to enzyme cofactor FAD
  Het Group MTE corresponds to enzyme cofactor Molybdopterin
3bdj
Crystal structure of bovine milk xanthine dehydrogenase with covalently bound oxipurinol inhibitor
Source: Bos taurus. Bovine. Organism_taxid: 9913
Chains: A, B (1286 residues)
Bound ligands:   Het Group FAD corresponds to enzyme cofactor FAD
  Het Group MTE corresponds to enzyme cofactor Molybdopterin
3etr
Crystal structure of xanthine oxidase in complex with lumazi
Source: Bos taurus. Bovine. Organism_taxid: 9913. Other_details: animal milk. Other_details: animal milk
Chains: A, B, C, L, M, N (164 residues) CATH domains: 3.10.20.30 1.10.150.120
Bound ligands:   Het Group FAD corresponds to enzyme cofactor FAD
  Het Group MTE corresponds to enzyme cofactor Molybdopterin
3eub
Crystal structure of desulfo-xanthine oxidase with xanthine
Source: Bos taurus. Bovine. Organism_taxid: 9913. Secretion: bovine milk. Secretion: bovine milk
Chains: A, B, C, J, K, L, S, T, U, 2, 3, 4 (162 residues) CATH domains: 3.10.20.30 1.10.150.120
Bound ligands:   Het Group FAD corresponds to enzyme cofactor FAD
  Het Group MTE corresponds to enzyme cofactor Molybdopterin
3nrz
Crystal structure of bovine xanthine oxidase in complex with hypoxanthine
Source: Bos taurus. Bovine,cow,domestic cattle,domestic cow. Organism_taxid: 9913. Other_details: milk. Other_details: milk
Chains: A, B, C, J, K, L (164 residues) CATH domains: 3.10.20.30 1.10.150.120
Bound ligands:   Het Group FAD corresponds to enzyme cofactor FAD
  Het Group MTE corresponds to enzyme cofactor Molybdopterin
3ns1
Crystal structure of bovine xanthine oxidase in complex with mercaptopurine
Source: Bos taurus. Bovine,cow,domestic cattle,domestic cow. Organism_taxid: 9913. Other_details: milk. Other_details: milk
Chains: A, B, C, J, K, L (164 residues) CATH domains: 3.10.20.30 1.10.150.120
Bound ligands:   Het Group FAD corresponds to enzyme cofactor FAD
  Het Group MTE corresponds to enzyme cofactor Molybdopterin
3nvv
Crystal structure of bovine xanthine oxidase in complex with
Source: Bos taurus. Bovine,cow,domestic cattle,domestic cow. Organism_taxid: 9913. Other_details: milk. Other_details: milk
Chains: A, B, C, J, K, L (164 residues) CATH domains: 3.10.20.30 1.10.150.120
Bound ligands:   Het Group FAD corresponds to enzyme cofactor FAD
  Het Group MTE corresponds to enzyme cofactor Molybdopterin
3nvw
Crystal structure of bovine xanthine oxidase in complex with
Source: Bos taurus. Bovine,cow,domestic cattle,domestic cow. Organism_taxid: 9913. Other_details: milk. Other_details: milk
Chains: A, B, C, J, K, L (164 residues) CATH domains: 3.10.20.30 1.10.150.120
Bound ligands:   Het Group FAD corresponds to enzyme cofactor FAD
  Het Group MTE corresponds to enzyme cofactor Molybdopterin
3nvy
Crystal structure of bovine xanthine oxidase in complex with
Source: Bos taurus. Bovine,cow,domestic cattle,domestic cow. Organism_taxid: 9913. Other_details: milk. Other_details: milk
Chains: A, B, C, J, K, L (164 residues) CATH domains: 3.10.20.30 1.10.150.120
Bound ligands:   Het Group FAD corresponds to enzyme cofactor FAD
  Het Group MTE corresponds to enzyme cofactor Molybdopterin
3nvz
Crystal structure of bovine xanthine oxidase in complex with aldehyde
Source: Bos taurus. Bovine,cow,domestic cattle,domestic cow. Organism_taxid: 9913. Other_details: milk. Other_details: milk
Chains: A, B, C, J, K, L (164 residues) CATH domains: 3.10.20.30 1.10.150.120
Bound ligands:   Het Group FAD corresponds to enzyme cofactor FAD
  Het Group MTE corresponds to enzyme cofactor Molybdopterin
3rca
Crystal structure of reduced form of bovine xanthine oxidase complex with arsenite
Source: Bos taurus. Bovine,cow,domestic cattle,domestic cow. Organism_taxid: 9913. Other_details: milk. Other_details: milk
Chains: ( residues)
3sr6
Crystal structure of reduced bovine xanthine oxidase in comp arsenite
Source: Bos taurus. Bovine. Organism_taxid: 9913. Other_details: milk. Other_details: milk
Chains: A, B, C, J, K, L (164 residues) CATH domains: 3.10.20.30 1.10.150.120
Bound ligands:   Het Group FAD corresponds to enzyme cofactor FAD
  Het Group MTE corresponds to enzyme cofactor Molybdopterin
3una
Crystal structure of bovine milk xanthine dehydrogenase with
Source: Bos taurus. Bovine. Organism_taxid: 9913. Other_details: isolated from milk
Chains: A, B (1286 residues)
3unc
Crystal structure of bovine milk xanthine dehydrogenase to 1 resolution
Source: Bos taurus. Bovine. Organism_taxid: 9913. Other_details: isolated from milk
Chains: A, B (1286 residues)
3uni
Crystal structure of bovine milk xanthine dehydrogenase with bound
Source: Bos taurus. Bovine. Organism_taxid: 9913. Other_details: isolated from milk
Chains: A, B (1289 residues)