_EC 1.17.1.4 Xanthine dehydrogenase. 28 PDB entries  
EC 1.-.-.- Oxidoreductases. [8,663 PDB entries]
EC 1.17.-.- Acting on Ch or CH(2) groups. [263 PDB entries]
EC 1.17.1.- With NAD(+) or NADP(+) as acceptor. [72 PDB entries]
EC 1.17.1.4 Xanthine dehydrogenase. [28 PDB entries]    
1fiq

Pathway: Xanthine Dehydrogenase
Reaction: (1) Xanthine + NAD(+) + H(2)O = urate + Nadh. (2) Hypoxanthine + NAD(+) + H(2)O = xanthine + Nadh.
 


Xanthine
+
NAD(+)
+ H(2)O
=
urate
+
NADH

Hypoxanthine
+
NAD(+)
+ H(2)O
=
xanthine
+
NADH
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): NAD-xanthine dehydrogenase. Xanthine oxidoreductase. Xanthine-NAD oxidoreductase. Xanthine/NAD(+) oxidoreductase.
Cofactor(s): FAD; Iron-sulfur; Mo cation.
 

FAD

Iron-sulfur
Mo cation
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Comments: Acts on a variety of purines and aldehydes, including hypoxanthine. The mammalian enzyme can also convert all-trans retinol to all-trans- retinoate, while the substrate is bound to a retinoid-binding protein. The enzyme from eukaryotes contains [2Fe-2S], Fad and a molybdenum center. The mammallian enzyme predominantly exists as the NAD-dependent dehydrogenase (EC 1.17.1.4). During purification the enzyme is largely converted to an O(2)- dependent form, Ec 1.17.3.2.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 28 PDB entries in enzyme class E.C.1.17.1.4

  PDB code Protein
1fiq
Crystal structure of xanthine oxidase from bovine milk
Source: Bos taurus. Cattle. Organism_taxid: 9913. Secretion: milk. Secretion: milk
Chains: A, B, C (164 residues) CATH domains: 3.10.20.30 1.10.150.120
Bound ligands:   Het Group MTE is 45.83% similar to enzyme reactant Xanthine
  Het Group MTE is 45.83% similar to enzyme product Xanthine
  Het Group FAD corresponds to enzyme cofactor FAD
1fo4
Crystal structure of xanthine dehydrogenase isolated from bo
Source: Bos taurus. Cattle. Organism_taxid: 9913. Secretion: milk
Chains: A, B (1299 residues) CATH domains: 3.10.20.30 1.10.150.120 3.30.43.10 3.30.465.10 3.30.390.50 3.30.365.10 3.90.1170.50 3.30.365.10 3.30.365.10 3.30.365.10
Bound ligands:   Het Group MTE is 45.83% similar to enzyme reactant Xanthine
  Het Group MTE is 45.83% similar to enzyme product Xanthine
  Het Group FAD corresponds to enzyme cofactor FAD
1n5x
Xanthine dehydrogenase from bovine milk with inhibitor tei-6
Source: Bos taurus. Cattle. Organism_taxid: 9913. Secretion: milk
Chains: A, B (1290 residues) CATH domains: 3.10.20.30 1.10.150.120 Unassigned 3.30.465.10 3.30.390.50 3.30.365.10 3.90.1170.50 3.30.365.10 3.30.365.10 3.30.365.10
Bound ligands:   Het Group MTE is 45.83% similar to enzyme reactant xanthine
  Het Group MTE is 45.83% similar to enzyme product xanthine
  Het Group FAD corresponds to enzyme cofactor FAD
1v97
Crystal structure of bovine milk xanthine dehydrogenase fyx- form
Source: Bos taurus. Cattle. Organism_taxid: 9913
Chains: A, B (1298 residues) CATH domains: 3.10.20.30 1.10.150.120 Unassigned 3.30.465.10 3.30.390.50 3.30.365.10 3.90.1170.50 3.30.365.10 3.30.365.10 3.30.365.10
Bound ligands:   Het Group MTE is 45.83% similar to enzyme reactant Xanthine
  Het Group MTE is 45.83% similar to enzyme product Xanthine
  Het Group FAD corresponds to enzyme cofactor FAD
1vdv
Bovine milk xanthine dehydrogenase y-700 bound form
Source: Bos taurus. Cattle. Organism_taxid: 9913. Secretion: milk
Chains: A, B (1299 residues) CATH domains: 3.10.20.30 1.10.150.120 Unassigned 3.30.465.10 3.30.390.50 3.30.365.10 3.90.1170.50 3.30.365.10 3.30.365.10 3.30.365.10
Bound ligands:   Het Group MTE is 45.83% similar to enzyme reactant Xanthine
  Het Group MTE is 45.83% similar to enzyme product Xanthine
  Het Group FAD corresponds to enzyme cofactor FAD
1wyg
Crystal structure of a rat xanthine dehydrogenase triple mut (c535a, c992r and c1324s)
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chain: A (1297 residues) CATH domains: 3.10.20.30 1.10.150.120 Unassigned Unassigned 3.30.390.50 3.30.365.10 3.90.1170.50 3.30.365.10 3.30.365.10 3.30.365.10
Bound ligand:   Het Group FAD corresponds to enzyme cofactor FAD
2ckj
Human milk xanthine oxidoreductase
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: breast milk. Other_details: milk kindly donated by mothers at the intensive care baby units at the bristol royal infirmary and southmead hospital, bristol, uk
Chains: A, B, C, D (1264 residues) CATH domain: Unassigned
Bound ligand:   Het Group FAD corresponds to enzyme cofactor FAD
2e1q
Crystal structure of human xanthine oxidoreductase mutant, g
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (1307 residues)
Bound ligands:   Het Group MTE is 45.83% similar to enzyme reactant Xanthine
  Het Group MTE is 45.83% similar to enzyme product Xanthine
  Het Group FAD corresponds to enzyme cofactor FAD
2e3t
Crystal structure of rat xanthine oxidoreductase mutant (w33 f336l)
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chains: A, B (1291 residues)
Bound ligands:   Het Group URC corresponds to enzyme product Urate
  Het Group URC is 91.67% similar to enzyme product Xanthine
  Het Group FAD corresponds to enzyme cofactor FAD
3am9
Complex of bovine xanthine dehydrogenase and trihydroxy fyx-
Source: Bos taurus. Bovine. Organism_taxid: 9913
Chains: A, B (1293 residues)
Bound ligands:   Het Group MTE is 45.00% similar to enzyme reactant Xanthine
  Het Group MTE is 45.00% similar to enzyme product Xanthine
  Het Group FAD corresponds to enzyme cofactor FAD
3amz
Bovine xanthine oxidoreductase urate bound form
Source: Bos taurus. Bovine. Organism_taxid: 9913
Chains: A, B (1291 residues)
Bound ligands:   Het Group MTE is 45.00% similar to enzyme reactant Xanthine
  Het Group NAI corresponds to enzyme reactant NAD(+)
  Het Group URC corresponds to enzyme product Urate
  Het Group NAI corresponds to enzyme reactant NAD(+)
  Het Group MTE is 45.00% similar to enzyme product Xanthine
  Het Group FAD corresponds to enzyme cofactor FAD
3an1
Crystal structure of rat d428a mutant, urate bound form
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (1299 residues)
Bound ligands:   Het Group URC corresponds to enzyme product Urate
  Het Group URC is 91.00% similar to enzyme product Xanthine
  Het Group FAD corresponds to enzyme cofactor FAD
3ax7
Bovine xanthine oxidase, protease cleaved form
Source: Bos taurus. Bovine. Organism_taxid: 9913
Chains: A, B (1225 residues)
3ax9
Bovine xanthine oxidase, protease cleaved form
Source: Bos taurus. Bovine. Organism_taxid: 9913
Chains: A, B (1225 residues)
Bound ligand:   Het Group FAD corresponds to enzyme cofactor FAD
3b9j
Structure of xanthine oxidase with 2-hydroxy-6-methylpurine
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organism_taxid: 9913
Chains: A, B, C, I, J, K (162 residues) CATH domains: 3.10.20.30 1.10.150.120
Bound ligands:   Het Group MTE is 45.00% similar to enzyme reactant Xanthine
  Het Group MTE is 45.00% similar to enzyme product Xanthine
  Het Group FAD corresponds to enzyme cofactor FAD
3bdj
Crystal structure of bovine milk xanthine dehydrogenase with covalently bound oxipurinol inhibitor
Source: Bos taurus. Bovine. Organism_taxid: 9913
Chains: A, B (1286 residues)
Bound ligands:   Het Group MTE is 45.83% similar to enzyme reactant xanthine
  Het Group MTE is 45.83% similar to enzyme product xanthine
  Het Group FAD corresponds to enzyme cofactor FAD
3etr
Crystal structure of xanthine oxidase in complex with lumazi
Source: Bos taurus. Bovine. Organism_taxid: 9913. Other_details: animal milk. Other_details: animal milk
Chains: A, B, C, L, M, N (164 residues) CATH domains: 3.10.20.30 1.10.150.120
Bound ligands:   Het Group MTE is 45.00% similar to enzyme reactant Xanthine
  Het Group MTE is 45.00% similar to enzyme product Xanthine
  Het Group FAD corresponds to enzyme cofactor FAD
3eub
Crystal structure of desulfo-xanthine oxidase with xanthine
Source: Bos taurus. Bovine. Organism_taxid: 9913. Secretion: bovine milk. Secretion: bovine milk
Chains: A, B, C, J, K, L, S, T, U, 2, 3, 4 (162 residues) CATH domains: 3.10.20.30 1.10.150.120
Bound ligands:   Het Group MTE is 45.00% similar to enzyme reactant Xanthine
  Het Group MTE is 45.00% similar to enzyme product Xanthine
  Het Group FAD corresponds to enzyme cofactor FAD
3nrz
Crystal structure of bovine xanthine oxidase in complex with hypoxanthine
Source: Bos taurus. Bovine,cow,domestic cattle,domestic cow. Organism_taxid: 9913. Other_details: milk. Other_details: milk
Chains: A, B, C, J, K, L (164 residues) CATH domains: 3.10.20.30 1.10.150.120
Bound ligands:   Het Group MTE is 45.00% similar to enzyme reactant Xanthine
  Het Group MTE is 45.00% similar to enzyme product Xanthine
  Het Group FAD corresponds to enzyme cofactor FAD
3ns1
Crystal structure of bovine xanthine oxidase in complex with mercaptopurine
Source: Bos taurus. Bovine,cow,domestic cattle,domestic cow. Organism_taxid: 9913. Other_details: milk. Other_details: milk
Chains: A, B, C, J, K, L (164 residues) CATH domains: 3.10.20.30 1.10.150.120
Bound ligands:   Het Group MTE is 45.00% similar to enzyme reactant Xanthine
  Het Group MTE is 45.00% similar to enzyme product Xanthine
  Het Group FAD corresponds to enzyme cofactor FAD
3nvv
Crystal structure of bovine xanthine oxidase in complex with
Source: Bos taurus. Bovine,cow,domestic cattle,domestic cow. Organism_taxid: 9913. Other_details: milk. Other_details: milk
Chains: A, B, C, J, K, L (164 residues) CATH domains: 3.10.20.30 1.10.150.120
Bound ligands:   Het Group MTE is 45.83% similar to enzyme reactant xanthine
  Het Group MTE is 45.83% similar to enzyme product xanthine
  Het Group FAD corresponds to enzyme cofactor FAD
3nvw
Crystal structure of bovine xanthine oxidase in complex with
Source: Bos taurus. Bovine,cow,domestic cattle,domestic cow. Organism_taxid: 9913. Other_details: milk. Other_details: milk
Chains: A, B, C, J, K, L (164 residues) CATH domains: 3.10.20.30 1.10.150.120
Bound ligands:   Het Group MTE is 45.83% similar to enzyme reactant xanthine
  Het Group MTE is 45.83% similar to enzyme product xanthine
  Het Group FAD corresponds to enzyme cofactor FAD
3nvy
Crystal structure of bovine xanthine oxidase in complex with
Source: Bos taurus. Bovine,cow,domestic cattle,domestic cow. Organism_taxid: 9913. Other_details: milk. Other_details: milk
Chains: A, B, C, J, K, L (164 residues) CATH domains: 3.10.20.30 1.10.150.120
Bound ligands:   Het Group MTE is 45.83% similar to enzyme reactant xanthine
  Het Group MTE is 45.83% similar to enzyme product xanthine
  Het Group FAD corresponds to enzyme cofactor FAD
3nvz
Crystal structure of bovine xanthine oxidase in complex with aldehyde
Source: Bos taurus. Bovine,cow,domestic cattle,domestic cow. Organism_taxid: 9913. Other_details: milk. Other_details: milk
Chains: A, B, C, J, K, L (164 residues) CATH domains: 3.10.20.30 1.10.150.120
Bound ligands:   Het Group MTE is 45.83% similar to enzyme reactant xanthine
  Het Group MTE is 45.83% similar to enzyme product xanthine
  Het Group FAD corresponds to enzyme cofactor FAD
3sr6
Crystal structure of reduced bovine xanthine oxidase in comp arsenite
Source: Bos taurus. Bovine. Organism_taxid: 9913. Other_details: milk. Other_details: milk
Chains: A, B, C, J, K, L (164 residues) CATH domains: 3.10.20.30 1.10.150.120
Bound ligands:   Het Group MTE is 45.83% similar to enzyme reactant xanthine
  Het Group MTE is 45.83% similar to enzyme product xanthine
  Het Group FAD corresponds to enzyme cofactor FAD
3una
Crystal structure of bovine milk xanthine dehydrogenase with
Source: Bos taurus. Bovine. Organism_taxid: 9913. Other_details: isolated from milk
Chains: A, B (1286 residues)
3unc
Crystal structure of bovine milk xanthine dehydrogenase to 1 resolution
Source: Bos taurus. Bovine. Organism_taxid: 9913. Other_details: isolated from milk
Chains: A, B (1286 residues)
3uni
Crystal structure of bovine milk xanthine dehydrogenase with bound
Source: Bos taurus. Bovine. Organism_taxid: 9913. Other_details: isolated from milk
Chains: A, B (1289 residues)