_EC 1.17.1.3 Leucoanthocyanidin reductase. 0 PDB entries  
EC 1.-.-.- Oxidoreductases. [8,663 PDB entries]
EC 1.17.-.- Acting on Ch or CH(2) groups. [263 PDB entries]
EC 1.17.1.- With NAD(+) or NADP(+) as acceptor. [72 PDB entries]
EC 1.17.1.3 Leucoanthocyanidin reductase. [-]    

Pathway: Flavonoid Biosynthesis
Reaction: (2R,3S)-catechin + NADP(+) + H(2)O = 2,3-trans-3,4-cis-leucocyanidin + Nadph.
 

(2R,3S)-catechin
+
NADP(+)
+ H(2)O
=
2,3-trans-3,4-cis-leucocyanidin
+
NADPH
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Leucocyanidin reductase.
Comments: Catalyzes the synthesis of catechin, catechin-4-beta-ol (leucocyanidin) and the related flavan-3-ols afzelechin and gallocatechin, which are initiating monomers in the synthesis of plant polymeric proanthocyanidins or condensed tannins. While 2,3-trans-3,4-cis-leucocyanidin is the preferred flavan-3,4- diol substrate, 2,3-trans-3,4-cis-leucodelphinidin and 2,3-trans-3, 4-cis-leucopelargonidin can also act as substrates, but more slowly. Nadh can replace nadph but is oxidized more slowly.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are no PDB entries in enzyme class E.C.1.17.1.3