_EC 1.14.99.37 Taxadiene 5-alpha-hydroxylase. 0 PDB entries  
EC 1.-.-.- Oxidoreductases. [8,127 PDB entries]
EC 1.14.-.- Acting on paired donors, with incorporation or reduction of molecu [1,370 PDB entries]
EC 1.14.99.- Miscellaneous (requires further characterization). [148 PDB entries]
EC 1.14.99.37 Taxadiene 5-alpha-hydroxylase. [-]    

Reaction: Taxa-4,11-diene + AH(2) + O(2) = taxa-4(20),11-dien-5-alpha-ol + A + H(2)O.
 


Taxa-4,11-diene
+ AH(2)
+
O(2)
=
taxa-4(20),11-dien-5-alpha-ol
+
+ H(2)O
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Cofactor(s): Heme-thiolate.
Comments: Involved in the biosynthesis of the diterpenoid antineoplastic drug Taxol (paclitaxel). The reaction includes rearrangement of the 4(5)-double bond to a 4(20)-double bond, possibly through allylic oxidation.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are no PDB entries in enzyme class E.C.1.14.99.37