_EC 1.14.99.29 Deoxyhypusine monooxygenase. 2 PDB entries  
EC 1.-.-.- Oxidoreductases. [9,401 PDB entries]
EC 1.14.-.- Acting on paired donors, with incorporation or reduction of molecu [1,566 PDB entries]
EC 1.14.99.- Miscellaneous (requires further characterization). [154 PDB entries]
EC 1.14.99.29 Deoxyhypusine monooxygenase. [2 PDB entries]    
4d4z

Pathway: EC 2.5.1.46
Reaction: [eIF5A]-deoxyhypusine + AH(2) + O(2) = [eIF5A]-hypusine + A + H(2)O.
 

[eIF5A]-deoxyhypusine
+ AH(2)
+
O(2)
= [eIF5A]-hypusine
+
+ H(2)O
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Deoxyhypusine dioxygenase. Deoxyhypusine hydroxylase. Dohh.
Comments: Catalyzes the final step in the formation of the amino acid hypusine in eukaryotic initiation factor 5A (eIF-5A) (formerly eIF-4D).
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 2 PDB entries in enzyme class E.C.1.14.99.29

  PDB code Protein
4d4z
Structure of human deoxyhypusine hydroxylase in complex with
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: B ( residues)
4d50
Structure of human deoxyhypusine hydroxylase
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (290 residues)
Bound ligand:   Het Group PER corresponds to enzyme reactant O(2)