_EC 1.14.99.10 Steroid 21-monooxygenase. 2 PDB entries  
EC 1.-.-.- Oxidoreductases. [8,663 PDB entries]
EC 1.14.-.- Acting on paired donors, with incorporation or reduction of molecu [1,436 PDB entries]
EC 1.14.99.- Miscellaneous (requires further characterization). [146 PDB entries]
EC 1.14.99.10 Steroid 21-monooxygenase. [2 PDB entries]    
2geg

Reaction: A C(21) steroid + (reduced NADPH--hemoprotein reductase) + O(2) = a 21-hydroxy-C(21)-steroid + (oxidized NADPH--hemoprotein reductase) + H(2)O.
 

C(21) steroid
+ (reduced NADPH--hemoprotein reductase)
+
O(2)
= 21-hydroxy-C(21)-steroid
+ (oxidized NADPH--hemoprotein reductase)
+ H(2)O
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): CYP21A2. Cytochrome p450 XXIA1. Steroid 21-hydroxylase.
Cofactor(s): Heme-thiolate.
Comments: Requires Nadph and ec 1.6.2.4. Responsible for the conversion of progesterone and 17-alpha- hydroxyprogesterone to their respective 21-hydroxylated derivatives, 11-deoxycorticosterone and 11-deoxycortisol. Involved in the biosynthesis of the hormones aldosterone and cortisol. Formerly Ec 1.14.1.8 and Ec 1.99.1.11.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 2 PDB entries in enzyme class E.C.1.14.99.10

  PDB code Protein
2geg
Theoretical model of human cyp21 (cytochrome p450, 21- hydroxylase) based on rabbit cyp2c5.
Source: Homo sapiens. Human
Chain: C (468 residues)
Bound ligand:   Het Group HEM is 46.00% similar to enzyme reactant steroid
3qz1
Crystal structure of bovine steroid of 21-hydroxylase (p450c
Source: Bos taurus. Bovine,cow,domestic cattle,domestic cow. Organism_taxid: 9913. Gene: cyp21, cyp21a1. Expressed in: escherichia coli. Expression_system_taxid: 668369.
Chains: A, B, C, D (445 residues) CATH domain: 1.10.630.10