_EC 1.14.16.2 Tyrosine 3-monooxygenase. 4 PDB entries  
EC 1.-.-.- Oxidoreductases. [8,127 PDB entries]
EC 1.14.-.- Acting on paired donors, with incorporation or reduction of molecu [1,370 PDB entries]
EC 1.14.16.- With reduced pteridine as one donor, and incorporation of one ato [41 PDB entries]
EC 1.14.16.2 Tyrosine 3-monooxygenase. [4 PDB entries]    
1toh

Pathway: Dopa Biosynthesis
Reaction: L-tyrosine + tetrahydrobiopterin + O(2) = L-dopa + 4a-hydroxytetrahydrobiopterin.
 


L-tyrosine
+
tetrahydrobiopterin
+
O(2)
=
L-dopa
+
4a-hydroxytetrahydrobiopterin
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): L-tyrosine hydroxylase. Tyrosine 3-hydroxylase. Tyrosine hydroxylase.
Cofactor(s): Iron.
Comments: Activated by phosphorylation, catalyzed by Ec 2.7.11.27. The 4a-hydroxytetrahydrobiopterin formed can dehydrate to 6,7- dihydrobiopterin, both spontaneously and by the action of Ec 4.2.1.96. The 6,7-dihydrobiopterin can be enzymically reduced back to tetrahydrobiopterin, by Ec 1.5.1.34, or slowly rearranges into the more stable compound 7,8-dihydrobiopterin.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 4 PDB entries in enzyme class E.C.1.14.16.2

  PDB code Protein
1toh
Tyrosine hydroxylase catalytic and tetramerization domains f
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Cell_line: bl21. Organ: adrenal gland. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (325 residues) CATH domain: 1.10.800.10
2mda
The solution structure of the regulatory domain of tyrosine hydroxylase
Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: th. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (95 residues) CATH domain: 0.0.0.0
2toh
Tyrosine hydroxylase catalytic and tetramerization domains f
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Strain: bl21 (de3) plyss. Organ: adrenal gland. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: first 155 residues truncated
Chain: A (336 residues) CATH domain: 1.10.800.10
Bound ligand:   Het Group HBI corresponds to enzyme reactant L-tyrosine
2xsn
Crystal structure of human tyrosine hydroxylase catalytic domain
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: r3-pl
Chains: A, B, C, D (335 residues) CATH domain: 1.10.800.10