_EC 1.14.13.99 24-hydroxycholesterol 7-alpha-hydroxylase. 0 PDB entries  
EC 1.-.-.- Oxidoreductases. [8,844 PDB entries]
EC 1.14.-.- Acting on paired donors, with incorporation or reduction of molecu [1,479 PDB entries]
EC 1.14.13.- With Nadh or nadph as one donor, and incorporation of one atom of [700 PDB entries]
EC 1.14.13.99 24-hydroxycholesterol 7-alpha-hydroxylase. [-]    

Reaction: (24R)-cholest-5-ene-3-beta,24-diol + Nadph + O(2) = (24R)-cholest-5-ene- 3-beta,7-alpha,24-triol + NADP(+) + H(2)O.
 

(24R)-cholest-5-ene-3-beta,24-diol
+
NADPH
+
O(2)
= (24R)-cholest-5-ene- 3-beta,7-alpha,24-triol
+
NADP(+)
+ H(2)O
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): 24-hydroxycholesterol 7-alpha-monooxygenase.
Cofactor(s): Heme-thiolate.
Comments: Found in liver microsomes and in ciliary non-pigmented epithelium. Specific for (24R)-cholest-5-ene-3-beta,24-diol as substrate.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are no PDB entries in enzyme class E.C.1.14.13.99