_EC 1.14.13.9 Kynurenine 3-monooxygenase. 5 PDB entries  
EC 1.-.-.- Oxidoreductases. [8,840 PDB entries]
EC 1.14.-.- Acting on paired donors, with incorporation or reduction of molecu [1,477 PDB entries]
EC 1.14.13.- With Nadh or nadph as one donor, and incorporation of one atom of [690 PDB entries]
EC 1.14.13.9 Kynurenine 3-monooxygenase. [5 PDB entries]    
4j2w

Pathway: Tryptophan Catabolism
Reaction: L-kynurenine + Nadph + O(2) = 3-hydroxy-L-kynurenine + NADP(+) + H(2)O.
 


L-kynurenine
+
NADPH
+
O(2)
=
3-hydroxy-L-kynurenine
+
NADP(+)
+ H(2)O
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Kynurenine 3-hydroxylase.
Cofactor(s): Fad.
 

FAD
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Comments: Formerly Ec 1.14.1.2 and Ec 1.99.1.5.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 5 PDB entries in enzyme class E.C.1.14.13.9

  PDB code Protein
4j2w
Crystal structure of kynurenine 3-monooxygenase (kmo-396prot
Source: Saccharomyces cerevisiae s288c. Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c
Chains: A, B (383 residues) CATH domain: Unassigned
Bound ligand:   Het Group FAD corresponds to enzyme cofactor FAD
4j31
Crystal structure of kynurenine 3-monooxygenase (kmo-396prot
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c
Chains: A, B (366 residues) CATH domain: Unassigned
Bound ligand:   Het Group FAD corresponds to enzyme cofactor FAD
4j33
Crystal structure of kynurenine 3-monooxygenase (kmo-394)
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Gene: bna4, ybl098w, ybl0828
Chains: A, B (383 residues) CATH domain: Unassigned
Bound ligand:   Het Group FAD corresponds to enzyme cofactor FAD
4j34
Crystal structure of kynurenine 3-monooxygenase - truncated position 394 plus his tag cleaved.
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Gene: bna4, ybl098w, ybl0828
Chains: A, B (378 residues) CATH domain: Unassigned
Bound ligand:   Het Group FAD corresponds to enzyme cofactor FAD
4j36
Cocrystal structure of kynurenine 3-monooxygenase in complex 648 inhibitor(kmo-394upf)
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Gene: bna4, ybl098w, ybl0828
Chains: A, B (371 residues) CATH domain: Unassigned
Bound ligands:   Het Group 1HR is 72.22% similar to enzyme reactant L-kynurenine
  Het Group FAD corresponds to enzyme cofactor FAD