_EC 1.14.13.70 Sterol 14-alpha-demethylase. 45 PDB entries  
EC 1.-.-.- Oxidoreductases. [8,844 PDB entries]
EC 1.14.-.- Acting on paired donors, with incorporation or reduction of molecu [1,479 PDB entries]
EC 1.14.13.- With Nadh or nadph as one donor, and incorporation of one atom of [700 PDB entries]
EC 1.14.13.70 Sterol 14-alpha-demethylase. [45 PDB entries]    
1e9x

Pathway: Sterol ring B, C, D modification
Reaction: A 14-alpha-methylsteroid + 3 O(2) + 3 nadph = a Delta(14)-steroid + formate + 3 NADP(+) + 4 H(2)O.
 

14-alpha-methylsteroid
+
3 × O(2)
+
3 × NADPH
= Delta(14)-steroid
+
formate
+
3 × NADP(+)
+ 4 × H(2)O
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Cytochrome P450 51. Lanosterol 14-alpha-demethylase. Lanosterol 14-demethylase. Obtusufoliol 14-demethylase.
Cofactor(s): Heme-thiolate.
Comments: This heme-thiolate (P450) enzyme acts on a range of steroids with a 14-alpha-methyl group, such as obtusifoliol and lanosterol. The enzyme catalyzes two successive hydroxylations of the 14-alpha- methyl group, followed by elimination as formate, leaving a 14(15) double bond.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 45 PDB entries in enzyme class E.C.1.14.13.70

  PDB code Protein
1e9x
Cytochrome p450 14 alpha-sterol demethylase (cyp51) from mycobacterium tuberculosis in complex with 4-phenylimidazole
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Cellular_location: cytoplasm. Gene: cyp51 or rv0764c or mtcy369.09c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (449 residues) CATH domain: 1.10.630.10
Bound ligand:   Het Group HEM is 62.00% similar to enzyme product 4-alpha-methyl-5-alpha-ergosta- 8,14,24(28)-trien-3-beta-ol
1ea1
Cytochrome p450 14 alpha-sterol demethylase (cyp51) from mycobacterium tuberculosis in complex with fluconazole
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Cellular_location: cytoplasm. Gene: cyp51 or rv0764c or mtcy369.09c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (447 residues) CATH domain: 1.10.630.10
Bound ligand:   Het Group HEM is 62.00% similar to enzyme product 4-alpha-methyl-5-alpha-ergosta- 8,14,24(28)-trien-3-beta-ol
1h5z
Cytochrome p450 14 alpha-sterol demethylase (cyp51) from mycobacterium tuberculosis in ferric low-spin state
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: hms174. Cellular_location: cytoplasm. Plasmid: pet17b. Gene: cyp51 or rv0764c or mtcy369.09c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (435 residues) CATH domain: 1.10.630.10
Bound ligand:   Het Group HEM is 62.00% similar to enzyme product 4-alpha-methyl-5-alpha-ergosta- 8,14,24(28)-trien-3-beta-ol
1u13
Crystal structure analysis of the c37l/c151t/c442a-triple mutant of cyp51 from mycobacterium tuberculosis
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: name=cyp51. Orderedlocusnames=rv0764c, mt0788, mb0787c. Orfnames=mtcy369.09c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (433 residues) CATH domain: 1.10.630.10
Bound ligand:   Het Group HEM is 62.00% similar to enzyme product 4-alpha-methyl-5-alpha-ergosta- 8,14,24(28)-trien-3-beta-ol
1x8v
Estriol-bound and ligand-free structures of sterol 14alpha- demethylase (cyp51)
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: cyp51. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (429 residues) CATH domain: 1.10.630.10
Bound ligand:   Het Group HEM is 62.00% similar to enzyme product 4-alpha-methyl-5-alpha-ergosta- 8,14,24(28)-trien-3-beta-ol
2bz9
Ligand-free structure of sterol 14alpha-demethylase from mycobacterium tuberculosis in p2(1) space group
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (430 residues) CATH domain: 1.10.630.10
Bound ligand:   Het Group HEM is 62.00% similar to enzyme product 4-alpha-methyl-5-alpha-ergosta- 8,14,24(28)-trien-3-beta-ol
2ci0
High throughput screening and x-ray crystallography assisted evaluation of small molecule scaffolds for cyp51 inhibitors
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (422 residues) CATH domain: 1.10.630.10
Bound ligand:   Het Group HEM is 62.00% similar to enzyme product 4-alpha-methyl-5-alpha-ergosta- 8,14,24(28)-trien-3-beta-ol
2cib
High throughput screening and x-ray crystallography assisted evaluation of small molecule scaffolds for cyp51 inhibitors
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (420 residues) CATH domain: 1.10.630.10
Bound ligand:   Het Group HEM is 62.00% similar to enzyme product 4-alpha-methyl-5-alpha-ergosta- 8,14,24(28)-trien-3-beta-ol
2vku
4,4'-dihydroxybenzophenone mimics sterol substrate in the binding site of sterol 14alpha-demethylase (cyp51) in the x-ray structure of the complex
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (445 residues) CATH domain: 1.10.630.10
Bound ligand:   Het Group HEM is 62.00% similar to enzyme product 4-alpha-methyl-5-alpha-ergosta- 8,14,24(28)-trien-3-beta-ol
2w09
Cyp51 of m. Tuberculosis bound to an inhibitor cis-4- methyl-n-[(1s)-3-(methylsulfanyl)-1-(pyridin-4- ylcarbamoyl)propyl]cyclohexanecarboxamide
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (421 residues) CATH domain: 1.10.630.10
Bound ligand:   Het Group HEM is 62.00% similar to enzyme product 4-alpha-methyl-5-alpha-ergosta- 8,14,24(28)-trien-3-beta-ol
2w0a
Cyp51 of m. Tuberculosis bound to an inhibitor n-[(1s)-2-methyl-1-(pyridin-4-ylcarbamoyl)propyl] cyclohexanecarboxamide
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (425 residues) CATH domain: 1.10.630.10
Bound ligand:   Het Group HEM is 62.00% similar to enzyme product 4-alpha-methyl-5-alpha-ergosta- 8,14,24(28)-trien-3-beta-ol
2w0b
Cyp51 of m. Tuberculosis bound to an inhibitor 3-{[(4- methylphenyl)sulfonyl]amino}propyl pyridin-4-ylcarbamate
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (440 residues) CATH domain: 1.10.630.10
Bound ligand:   Het Group HEM is 62.00% similar to enzyme product 4-alpha-methyl-5-alpha-ergosta- 8,14,24(28)-trien-3-beta-ol
2wuz
X-ray structure of cyp51 from trypanosoma cruzi in complex with fluconazole in alternative conformation
Source: Trypanosoma cruzi. Organism_taxid: 5693. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (444 residues) CATH domain: 1.10.630.10
Bound ligand:   Het Group HEM is 62.22% similar to enzyme product 4-alpha-methyl-5-alpha-ergosta-
2wv2
X-ray structure of cyp51 from the human pathogen trypanosoma brucei in complex with fluconazole
Source: Trypanosoma brucei. Organism_taxid: 5691. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (443 residues) CATH domain: 1.10.630.10
Bound ligand:   Het Group HEM is 62.22% similar to enzyme product 4-alpha-methyl-5-alpha-ergosta-
2wx2
X-ray structure of cyp51 from the human pathogen trypanosoma cruzi in complex with fluconazole
Source: Trypanosoma cruzi. Organism_taxid: 5693. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (441 residues) CATH domain: 1.10.630.10
Bound ligand:   Het Group HEM is 62.22% similar to enzyme product 4-alpha-methyl-5-alpha-ergosta-
2x2n
X-ray structure of cyp51 from trypanosoma brucei in complex with posaconazole in two different conformations
Source: Trypanosoma brucei. Organism_taxid: 5691. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (448 residues) CATH domain: 1.10.630.10
Bound ligand:   Het Group HEM is 62.22% similar to enzyme product 4-alpha-methyl-5-alpha-ergosta-
3g1q
Crystal structure of sterol 14-alpha demethylase (cyp51) from trypanosoma brucei in ligand free state
Source: Trypanosoma brucei. Organism_taxid: 5691. Cellular_location: membrane. Gene: cyp51, tb11.02.4080. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (448 residues) CATH domain: 1.10.630.10
Bound ligand:   Het Group HEM is 62.00% similar to enzyme product 4-alpha-methyl-5-alpha-ergosta- 8,14,24(28)-trien-3-beta-ol
3gw9
Crystal structure of sterol 14-alpha demethylase (cyp51) from trypanosoma brucei bound to an inhibitor n-(1-(2,4- dichlorophenyl)-2-(1h-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3, 4-oxaziazol-2-yl)benzamide
Source: Trypanosoma brucei. Organism_taxid: 5691. Cellular_location: membrane. Gene: cyp51, tb11.02.4080. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (450 residues) CATH domain: 1.10.630.10
Bound ligand:   Het Group HEM is 62.00% similar to enzyme product 4-alpha-methyl-5-alpha-ergosta- 8,14,24(28)-trien-3-beta-ol
3i3k
Crystal structure of human lanosterol 14alpha-demethylase (cyp51) in complex with ketoconazole
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cyp51, cyp51a1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (445 residues) CATH domain: 1.10.630.10
3jus
Crystal structure of human lanosterol 14alpha-demethylase (c complex with econazole
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cyp51, cyp51a1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (445 residues) CATH domain: 1.10.630.10
Bound ligand:   Het Group HEM is 60.87% similar to enzyme reactant Obtusifoliol
3juv
Crystal structure of human lanosterol 14alpha-demethylase (c
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cyp51, cyp51a1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (448 residues) CATH domain: 1.10.630.10
Bound ligand:   Het Group HEM is 62.00% similar to enzyme product 4-alpha-methyl-5-alpha-ergosta- 8,14,24(28)-trien-3-beta-ol
3k1o
Crystal structure of sterol 14-alpha demethylase (cyp51) fro trypanosoma cruzi in complex with a potential antichagasic posaconazole
Source: Trypanosoma cruzi. Organism_taxid: 5693. Gene: cyp51. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (442 residues) CATH domain: 1.10.630.10
Bound ligand:   Het Group HEM is 62.22% similar to enzyme product 4-alpha-methyl-5-alpha-ergosta-
3khm
Crystal structure of sterol 14alpha-demethylase (cyp51) from trypanosoma cruzi in complex with inhibitor fluconazole
Source: Trypanosoma cruzi. Organism_taxid: 5693. Gene: cyp51. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (441 residues) CATH domain: 1.10.630.10
Bound ligand:   Het Group HEM is 62.22% similar to enzyme product 4-alpha-methyl-5-alpha-ergosta-
3ksw
Crystal structure of sterol 14alpha-demethylase (cyp51) from trypanosoma cruzi in complex with an inhibitor vnf ((4-(4- chlorophenyl)-n-[2-(1h-imidazol-1-yl)-1-phenylethyl]benzami
Source: Trypanosoma cruzi. Organism_taxid: 5693. Gene: cyp51. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (444 residues) CATH domain: 1.10.630.10
Bound ligand:   Het Group HEM is 62.22% similar to enzyme product 4-alpha-methyl-5-alpha-ergosta-
3l4d
Crystal structure of sterol 14-alpha demethylase (cyp51) fro leishmania infantum in complex with fluconazole
Source: Leishmania infantum. Organism_taxid: 5671. Gene: cyp51, linj11.1100. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (448 residues) CATH domain: 1.10.630.10
Bound ligand:   Het Group HEM is 62.22% similar to enzyme product 4-alpha-methyl-5-alpha-ergosta-
3ld6
Crystal structure of human lanosterol 14alpha-demethylase (c complex with ketoconazole
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cyp51, cyp51a1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (445 residues) CATH domain: 1.10.630.10
Bound ligand:   Het Group HEM is 62.00% similar to enzyme product 4-alpha-methyl-5-alpha-ergosta- 8,14,24(28)-trien-3-beta-ol
3p99
Sterol 14alpha-demethylase (cyp51) from trypanosoma brucei i with delta7-14alpha-methylene-cyclopropyl-dihydrolanosterol
Source: Trypanosoma brucei. Organism_taxid: 5691. Gene: cyp51, tb11.02.4080. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (448 residues) CATH domain: 1.10.630.10
3tik
Sterol 14-alpha demethylase (cyp51) from trypanosoma brucei with the tipifarnib derivative 6-((4-chlorophenyl)(methoxy) 1h-imidazol-5-yl)methyl)-4-(2,6-difluorophenyl)-1-methylqui 2(1h)-one
Source: Trypanosoma brucei. Organism_taxid: 5691. Gene: cyp51, tb11.02.4080. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (450 residues) CATH domain: 1.10.630.10
Bound ligand:   Het Group HEM is 60.87% similar to enzyme reactant Obtusifoliol
3zg2
Sterol 14 alpha-demethylase (cyp51) from trypanosoma cruzi i complex with the pyridine inhibitor (s)-2-(4-chlorophenyl)- (pyridin-3-yl)-1-(4-(4-(trifluoromethyl)phenyl)piperazin-1- ethanone (epl-bs1246,udo)
Source: Trypanosoma cruzi. Organism_taxid: 5693. Strain: thlahuen. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (449 residues) CATH domain: 1.10.630.10
3zg3
Sterol 14-alpha demethylase (cyp51) from trypanosoma cruzi in complex with the pyridine inhibitor n-(1-(5-( trifluoromethyl)(pyridin-2-yl))piperidin-4yl)-n-(4-( trifluoromethyl)phenyl)pyridin-3-amine (epl-bs967, udd)
Source: Trypanosoma cruzi. Organism_taxid: 5693. Strain: thlahuen. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (445 residues) CATH domain: 1.10.630.10
4bjk
Cyp51 of trypanosoma brucei bound to (s)-n-(3-(1h-indol-3- yl)-1-oxo-1-(pyridin-4-ylamino)propan-2-yl)-3,3'-difluoro-( 1,1'-biphenyl)-4-carboxamide
Source: Trypanosoma brucei. Organism_taxid: 5691. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (450 residues) CATH domain: 1.10.630.10
4bmm
Crystal structure of trypanosoma cruzi cyp51 bound to the in (r)-n-(3-(1h-indol-3-yl)-1-oxo-1-(pyridin-4- ylamino)propan 2',3,5'-trifluoro-(1,1'-biphenyl)-4-carboxamide
Source: Trypanosoma cruzi. Organism_taxid: 353153. Strain: cl brener. Expressed in: escherichia coli. Expression_system_taxid: 83333. Expression_system_variant: hms174(de3).
Chains: A, B, C, D (441 residues) CATH domain: 1.10.630.10
4by0
Crystal structure of trypanosoma cruzi cyp51 bound to the inhibitor (r)-n-(3-(1h-indol-3-yl)-1-oxo-1-(pyridin-4- ylamino)propan-2-yl)-3,3'-difluoro-(1,1'-biphenyl)-4- carboxamide
Source: Trypanosoma cruzi. Organism_taxid: 5693. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (441 residues) CATH domain: 1.10.630.10
4c0c
Crystal structure of trypanosoma cruzi cyp51 bound to the inhibitor (r)-n-(3-(1h-indol-3-yl)-1-oxo-1-(pyridin-4- ylamino)propan-2-yl)-4-(4-(2,4-difluorophenyl)piperazin-1- yl)-2-fluorobenzamide.
Source: Trypanosoma cruzi. Organism_taxid: 5693. Expressed in: escherichia coli k-12. Expression_system_taxid: 83333.
Chain: A (446 residues) CATH domain: 1.10.630.10
4c27
Crystal structure of trypanosoma cruzi cyp51 bound to the inhibitor (r)-n-(3-(1h-indol-3-yl)-1-oxo-1-(pyridin-4- 4-ylamino)propan-2-yl)-2-fluoro-4-(4-(4-(trifluoromethyl) phenyl)piperazin-1-yl)benzamide
Source: Trypanosoma cruzi. Organism_taxid: 5693. Expressed in: escherichia coli k-12. Expression_system_taxid: 83333. Expression_system_variant: hms174(de3).
Chains: A, B (444 residues) CATH domain: 1.10.630.10
Bound ligand:   Het Group EDO is 40.00% similar to enzyme product Formate
4c28
Crystal structure of trypanosoma cruzi cyp51 bound to the inhibitor (r)-n-(3-(1h-indol-3-yl)-1-oxo-1-(pyridin-4- ylamino)propan-2-yl)-4-(4-(4-chlorophenyl)piperazin-1-yl)- 2-fluorobenzamide.
Source: Trypanosoma cruzi. Organism_taxid: 5693. Expressed in: escherichia coli k-12. Expression_system_taxid: 83333. Expression_system_variant: hms174(de3).
Chains: A, B (443 residues) CATH domain: 1.10.630.10
Bound ligand:   Het Group EDO is 40.00% similar to enzyme product Formate
4ck8
Sterol 14-alpha demethylase (cyp51)from trypanosoma cruzi in with (r)-1-(2,4-dichlorophenyl)-2-(1h-imidazol-1-yl)ethyl 4-(4-(3,4-dichlorophenyl)piperazin-1-yl)phenylcarbamate (lf
Source: Trypanosoma cruzi. Organism_taxid: 5693. Strain: thlahuen. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (449 residues) CATH domain: 1.10.630.10
4ck9
Sterol 14-alpha demethylase (cyp51)from trypanosoma cruzi in complex with (s)-1-(4-chlorophenyl)-2-(1h-imidazol-1-yl) ethyl 4-isopropylphenylcarbamate (lft)
Source: Trypanosoma cruzi. Organism_taxid: 5693. Strain: thlahuen. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (434 residues) CATH domain: 1.10.630.10
4cka
Sterol 14-alpha demethylase (cyp51)from trypanosoma cruzi in complex with (s)-1-(4-fluorophenyl)-2-(1h-imidazol-1-yl) ethyl 4-isopropylphenylcarbamate (lfs)
Source: Trypanosoma cruzi. Organism_taxid: 5693. Strain: thlahuen. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (434 residues) CATH domain: 1.10.630.10
4coh
Crystal structure of trypanosoma cruzi cyp51 bound to the sulfonamide derivative of the 4-aminopyridyl-based inhibito
Source: Trypanosoma cruzi. Organism_taxid: 5693. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (442 residues) CATH domain: 1.10.630.10
4g3j
Sterol 14-alpha demethylase (cyp51) from trypanosoma brucei with the vni derivative (r)-n-(1-(2,4-dichlorophenyl)-2-(1h triazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzam vni-triazole (vnt)]
Source: Trypanosoma brucei. Organism_taxid: 5691. Gene: cyp51, tb11.02.4080. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (448 residues) CATH domain: 1.10.630.10
4g7g
Sterol 14-alpha demethylase (cyp51) from trypanosoma brucei with the vni derivative (r)-n-(1-(3,4'-difluorobiphenyl-4-y imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benza [vni/vnf (vfv)]
Source: Trypanosoma brucei. Organism_taxid: 5691. Gene: cyp51, tb11.02.4080. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (448 residues) CATH domain: 1.10.630.10
4h6o
Sterol 14-alpha demethylase (cyp51)from trypanosoma cruzi in with the inhibitor neu321 (1-(3-(4-chloro-3,5-dimethylpheno benzyl)-1h-imidazole
Source: Trypanosoma cruzi. Organism_taxid: 5693. Strain: tulahuen. Gene: cyp51. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (435 residues)
Bound ligand:   Het Group HEM is 62.22% similar to enzyme product 4-alpha-methyl-5-alpha-ergosta-
4lxj
Saccharomyces cerevisiae lanosterol 14-alpha demethylase wit lanosterol bound
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: erg11, cyp51, yhr007c. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932
Chain: A (530 residues)
Bound ligand:   Het Group OXY corresponds to enzyme reactant O(2)
4uqh
Crystal structure of trypanosoma cruzi cyp51 bound to the inhibitor (r)-n-(3-(1h-indol-3-yl)-1-oxo-1-(pyridin-4- ylamino)propan-2-yl)-4-(4-(3,4-difluorophenyl)piperazin-1- yl)-2-fluorobenzamide.
Source: Trypanosoma cruzi. Organism_taxid: 5693. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (443 residues) CATH domain: 1.10.630.10