_EC 1.14.13.157 1,8-cineole 2-exo-monooxygenase. 18 PDB entries  
EC 1.-.-.- Oxidoreductases. [9,068 PDB entries]
EC 1.14.-.- Acting on paired donors, with incorporation or reduction of molecu [1,517 PDB entries]
EC 1.14.13.- With Nadh or nadph as one donor, and incorporation of one atom of [706 PDB entries]
EC 1.14.13.157 1,8-cineole 2-exo-monooxygenase. [18 PDB entries]    
1tqn

Reaction: 1,8-cineole + Nadph + O(2) = 2-exo-hydroxy-1,8-cineole + NADP(+) + H(2)O.
 


1,8-cineole
+
NADPH
+
O(2)
= 2-exo-hydroxy-1,8-cineole
+
NADP(+)
+ H(2)O
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): CYP3A4.
Cofactor(s): Heme-thiolate.
Comments: The mammalian enzyme, expressed in liver microsomes, performs a variety of oxidation reactions of structurally unrelated compounds, including stereoids, fatty acids, and xenobiotics. Cf. Ec 1.14.13.97, Ec 1.14.13.67 and Ec 1.14.13.32.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 18 PDB entries in enzyme class E.C.1.14.13.157

  PDB code Protein
1tqn
Crystal structure of human microsomal p450 3a4
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cyp3a4. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (468 residues) CATH domain: 1.10.630.10
1w0e
Crystal structure of human cytochrome p450 3a4
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: liver. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (453 residues) CATH domain: 1.10.630.10
1w0f
Crystal structure of human cytochrome p450 3a4
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: liver. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (459 residues) CATH domain: 1.10.630.10
1w0g
Crystal structure of human cytochrome p450 3a4
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: liver. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (455 residues) CATH domain: 1.10.630.10
2j0d
Crystal structure of human p450 3a4 in complex with erythromycin
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: liver. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (446 residues) CATH domain: 1.10.630.10
2v0m
Crystal structure of human p450 3a4 in complex with ketoconazole
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: liver. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (455 residues) CATH domain: 1.10.630.10
3nxu
Crystal structure of human cytochrome p4503a4 bound to an in ritonavir
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cyp3a3, cyp3a4. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (457 residues) CATH domain: 1.10.630.10
3tjs
Crystal structure of the complex between human cytochrome p4 desthiazolylmethyloxycarbonyl ritonavir
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cyp3a3, cyp3a4. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (449 residues) CATH domain: 1.10.630.10
3ua1
Crystal structure of the cytochrome p4503a4-bromoergocryptin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cyp3a4, cyp3a3. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (456 residues) CATH domain: 1.10.630.10
4i3q
Crystal structure of human cyp3a4 coordinated to a water mol
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cyp3a4, cyp3a3. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (465 residues) CATH domain: 1.10.630.10
4i4g
Crystal structure of cyp3a4 ligated to oxazole-substituted desoxyritonavir
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cyp3a4, cyp3a3. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (459 residues) CATH domain: 1.10.630.10
4i4h
Crystal structure of cyp3a4 ligated to pyridine-substituted desoxyritonavir
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cyp3a4, cyp3a3. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (457 residues) CATH domain: 1.10.630.10
4k9t
Complex of cyp3a4 with a desoxyritonavir analog
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cyp3a3, cyp3a4. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (455 residues) CATH domain: 1.10.630.10
4k9u
Complex of human cyp3a4 with a desoxyritonavir analog
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: human. Gene: cyp3a3, cyp3a4. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (450 residues) CATH domain: 1.10.630.10
4k9v
Complex of cyp3a4 with a desoxyritonavir analog
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: human. Gene: cyp3a3, cyp3a4. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (456 residues) CATH domain: 1.10.630.10
4k9w
Complex of human cyp3a4 with a desoxyritonavir analog
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: human. Gene: cyp3a3, cyp3a4. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (458 residues) CATH domain: 1.10.630.10
4k9x
Complex of human cyp3a4 with a desoxyritonavir analog
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: human. Gene: cyp3a3, cyp3a4. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (449 residues) CATH domain: 1.10.630.10
4ny4
Crystal structure of cyp3a4 in complex with an inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cyp3a3, cyp3a4, cyp3a4 cyp3a3. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (460 residues) CATH domain: 1.10.630.10