_EC 1.14.11.19 Leucocyanidin oxygenase. 1 PDB entries  
EC 1.-.-.- Oxidoreductases. [3,392 PDB entries]
EC 1.14.-.- Acting on paired donors, with incorporation or reduction of molecu [540 PDB entries]
EC 1.14.11.- With 2-oxoglutarate as one donor, and incorporation of one atom e [60 PDB entries]
EC 1.14.11.19 Leucocyanidin oxygenase. [1 PDB entries]    
1gp6

Pathway: Anthocyanin Biosynthesis
Reaction: Leucocyanidin + 2-oxoglutarate + O(2) = cis- and trans-dihydroquercetins + succinate + CO(2) + H(2)O.
 


Leucocyanidin
+
2-oxoglutarate
+
O(2)
= cis- and trans-dihydroquercetins
+
succinate
+
CO(2)
+ H(2)O
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Anthocyanidin synthase. Leucoanthocyanidin dioxygenase.
Cofactor(s): Fe(2+); L-ascorbate.
 
Fe(2+)

L-ascorbate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Comments: Involved in the pathway by which many flowering plants make anthocyanin (glycosylated anthocyandin) flower pigments. The intermediates are transformed into cis- and trans- dihydroquercetin, which the enzyme can also oxidize to quercetin. Acidification of the products gives anthocyanidin, which, however, may not be a natural precursor of the anthocyanins.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 1 PDB entries in enzyme class E.C.1.14.11.19

  PDB code Protein
1gp6
Anthocyanidin synthase from arabidopsis thaliana complexed with trans-dihydroquercetin (with 30 min exposure to o2)
Source: Arabidopsis thaliana. Mouse-ear cress. Organism_taxid: 3702. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (350 residues) CATH domain: 2.60.120.330
Bound ligands:   Het Group QUE corresponds to enzyme reactant Leucocyanidin
  Het Group SIN corresponds to enzyme product succinate