_EC 1.13.11.6 3-hydroxyanthranilate 3,4-dioxygenase. 12 PDB entries  
EC 1.-.-.- Oxidoreductases. [8,840 PDB entries]
EC 1.13.-.- Acting on single donors with incorporation of molecular oxygen. [310 PDB entries]
EC 1.13.11.- With incorporation of two atoms of oxygen. [275 PDB entries]
EC 1.13.11.6 3-hydroxyanthranilate 3,4-dioxygenase. [12 PDB entries]    
1yfu

Pathway: (later stages)
Reaction: 3-hydroxyanthranilate + O(2) = 2-amino-3-carboxymuconate semialdehyde.
 


3-hydroxyanthranilate
+
O(2)
=
2-amino-3-carboxymuconate semialdehyde
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): 3-hydroxyanthranilate oxygenase. 3-hydroxyanthranilic acid dioxygenase. 3-hydroxyanthranilic acid oxidase.
Cofactor(s): Fe cation.
Comments: The product of the reaction spontaneously rearrange to quinolinic acid (quin). Formerly Ec 1.13.1.6.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 12 PDB entries in enzyme class E.C.1.13.11.6

  PDB code Protein
1yfu
Crystal structure of 3-hydroxyanthranilate-3,4-dioxygenase f ralstonia metallidurans
Source: Cupriavidus metallidurans. Organism_taxid: 119219. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (174 residues) CATH domain: 2.60.120.10
1yfw
Crystal structure of 3-hydroxyanthranilate-3,4-dioxygenase f ralstonia metallidurans complexed with 4-chloro-3-hydroxyan acid and o2
Source: Cupriavidus metallidurans. Organism_taxid: 119219. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (174 residues) CATH domain: 2.60.120.10
Bound ligands:   Het Group 4AA is 91.67% similar to enzyme reactant 3-hydroxyanthranilate
  Het Group OXY corresponds to enzyme reactant O(2)
1yfx
Crystal structure of 3-hydroxyanthranilate-3,4-dioxygenase f ralstonia metallidurans complexed with 4-chloro-3-hydroxyan acid and no
Source: Cupriavidus metallidurans. Organism_taxid: 119219. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (174 residues) CATH domain: 2.60.120.10
Bound ligand:   Het Group 4AA is 91.67% similar to enzyme reactant 3-hydroxyanthranilate
1yfy
Crystal structure of 3-hydroxyanthranilate-3,4-dioxygenase f ralstonia metallidurans complexed with 3-hydroxyanthranilic
Source: Cupriavidus metallidurans. Organism_taxid: 119219. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (174 residues) CATH domain: 2.60.120.10
Bound ligand:   Het Group 3HA corresponds to enzyme reactant 3-hydroxyanthranilate
1zvf
The crystal structure of 3-hydroxyanthranilate 3,4- dioxygenase from saccharomyces cerevisiae
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (176 residues) CATH domain: 2.60.120.10
2qnk
Crystal structure of human 3-hydroxyanthranilate 3,4-dioxyge
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: brain. Gene: haao. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (286 residues)
3fe5
Crystal structure of 3-hydroxyanthranilate 3,4-dioxygenase from bovine kidney
Source: Bos taurus. Bovine. Organism_taxid: 9913
Chain: A (283 residues) CATH domain: Unassigned
4hsl
2.00 angstrom x-ray crystal structure of substrate-bound e11 hydroxyanthranilate-3,4-dioxygenase from cupriavidus metall
Source: Cupriavidus metallidurans. Organism_taxid: 266264. Strain: ch34 / atcc 43123 / dsm 2839. Gene: cupriavidus metallidurans, nbac, rmet_5193. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (174 residues) CATH domain: 2.60.120.10
Bound ligand:   Het Group 3HA corresponds to enzyme reactant 3-hydroxyanthranilate
4hvo
1.75 angstrom x-ray crystal structure of cufe reconstituted hydroxyanthranilate-3,4-dioxygenase from cupriavidus metall
Source: Cupriavidus metallidurans. Organism_taxid: 266264. Strain: ch34 / atcc 43123 / dsm 2839. Gene: cupriavidus metallidurans, nbac, rmet_5193. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (174 residues) CATH domain: 2.60.120.10
4hvq
X-ray crystal structure of fecu reconstituted 3-hydroxyanthr 4-dioxygenase from cupriavidus metallidurans
Source: Cupriavidus metallidurans. Organism_taxid: 266264. Strain: ch34 / atcc 43123 / dsm 2839. Gene: cupriavidus metallidurans, nbac, rmet_5193. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (154 residues) CATH domain: 2.60.120.10
4hvr
X-ray crystal structure of salicylic acid bound 3-hydroxyant 3,4-dioxygenase from cupriavidus metallidurans
Source: Cupriavidus metallidurans. Organism_taxid: 266264. Strain: ch34 / atcc 43123 / dsm 2839. Gene: cupriavidus metallidurans, nbac, rmet_5193. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (174 residues) CATH domain: 2.60.120.10
Bound ligand:   Het Group SAL is 75.00% similar to enzyme reactant 3-hydroxyanthranilate
4i3p
1.96 angstrom x-ray crystal structure of 3-hydroxyanthranila dioxygenase bound with 3-aminosalicylic acid from cupraavid metallidurans
Source: Cupriavidus metallidurans. Organism_taxid: 266264. Strain: ch34 / atcc 43123 / dsm 2839. Gene: cupriavidus metallidurans, nbac, rmet_5193. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (174 residues) CATH domain: 2.60.120.10
Bound ligand:   Het Group 1CW is 69.23% similar to enzyme reactant 3-hydroxyanthranilate