_EC 1.13.11.5 Homogentisate 1,2-dioxygenase. 5 PDB entries  
EC 1.-.-.- Oxidoreductases. [8,653 PDB entries]
EC 1.13.-.- Acting on single donors with incorporation of molecular oxygen. [306 PDB entries]
EC 1.13.11.- With incorporation of two atoms of oxygen. [271 PDB entries]
EC 1.13.11.5 Homogentisate 1,2-dioxygenase. [5 PDB entries]    
1ey2

Reaction: Homogentisate + O(2) = 4-maleylacetoacetate.
 


Homogentisate
+
O(2)
=
4-maleylacetoacetate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Homogentisate oxygenase. Homogentisic acid oxidase. Homogentisicase.
Cofactor(s): Fe cation.
Comments: Formerly Ec 1.13.1.5 and Ec 1.99.2.5.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 5 PDB entries in enzyme class E.C.1.13.11.5

  PDB code Protein
1ey2
Human homogentisate dioxygenase with fe(ii)
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: liver. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (419 residues) CATH domains: Unassigned 2.60.120.10
1eyb
Crystal structure of apo human homogentisate dioxygenase
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: liver. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (419 residues) CATH domains: Unassigned 2.60.120.10
3zds
Structure of homogentisate 1,2-dioxygenase in complex with reaction intermediates of homogentisate with oxygen.
Source: Pseudomonas putida. Organism_taxid: 160488. Strain: kt2440. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: german collection of microorganisms (dsm)
Chains: A, B, C, D, E, F, G, H, I, J, K, L (425 residues) CATH domains: Unassigned 2.60.120.10
Bound ligands:   Het Group OXY corresponds to enzyme reactant O(2)
  Het Group M8O corresponds to enzyme product 4-maleylacetoacetate
4aq2
Resting state of homogentisate 1,2-dioxygenase
Source: Pseudomonas putida. Organism_taxid: 160488. Strain: kt2440. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: dsm
Chains: A, B, C, D, E, F, G, H, I, J, K, L (425 residues) CATH domains: Unassigned 2.60.120.10
4aq6
Substrate bound homogentisate 1,2-dioxygenase
Source: Pseudomonas putida. Organism_taxid: 160488. Strain: kt2440. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: dsm
Chains: A, B, C, D, E, F, G, H, I, J, K, L (425 residues) CATH domains: Unassigned 2.60.120.10
Bound ligand:   Het Group OMD corresponds to enzyme reactant Homogentisate