_EC 1.13.11.33 Arachidonate 15-lipoxygenase. 5 PDB entries  
EC 1.-.-.- Oxidoreductases. [8,844 PDB entries]
EC 1.13.-.- Acting on single donors with incorporation of molecular oxygen. [308 PDB entries]
EC 1.13.11.- With incorporation of two atoms of oxygen. [273 PDB entries]
EC 1.13.11.33 Arachidonate 15-lipoxygenase. [5 PDB entries]    
1lox

Reaction: Arachidonate + O(2) = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa- 5,8,11,13-tetraenoate.
 


Arachidonate
+
O(2)
= (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa- 5,8,11,13-tetraenoate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): 15-lipoxygenase. Arachidonate omega(6) lipoxygenase.
Cofactor(s): Fe cation.
Comments: The product is rapidly converted to the corresponding 15S-hydroxy compound.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 5 PDB entries in enzyme class E.C.1.13.11.33

  PDB code Protein
1lox
Rabbit reticulocyte 15-lipoxygenase
Source: Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986. Cell: reticulocyte. Cellular_location: cytoplasm
Chain: A (647 residues) CATH domains: 1.20.245.10 2.60.60.20 3.10.450.60
2abt
Human 15-lipoxygenase
Source: Homo sapiens. Human
Chain: A (661 residues)
2p0m
Revised structure of rabbit reticulocyte 15s-lipoxygenase
Source: Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986
Chains: A, B (662 residues) CATH domains: 2.60.60.20 1.20.245.10 3.10.450.60
3rde
Crystal structure of the catalytic domain of porcine leukocy lipoxygenase
Source: Sus scrofa. Pigs,swine,wild boar. Organism_taxid: 9823. Gene: alox12. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (552 residues) CATH domain: 1.20.245.10
4nre
The structure of human 15-lipoxygenase-2 with a substrate mi
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: alox15b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (675 residues) CATH domain: 2.60.60.20