_EC 1.13.11.31 Arachidonate 12-lipoxygenase. 5 PDB entries  
EC 1.-.-.- Oxidoreductases. [8,653 PDB entries]
EC 1.13.-.- Acting on single donors with incorporation of molecular oxygen. [306 PDB entries]
EC 1.13.11.- With incorporation of two atoms of oxygen. [271 PDB entries]
EC 1.13.11.31 Arachidonate 12-lipoxygenase. [5 PDB entries]    
1lox

Reaction: Arachidonate + O(2) = (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa- 5,8,10,14-tetraenoate.
 


Arachidonate
+
O(2)
= (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa- 5,8,10,14-tetraenoate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): 12-lipoxygenase.
Cofactor(s): Fe cation.
Comments: The product is rapidly reduced to the corresponding 12S-hydroxy compound.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 5 PDB entries in enzyme class E.C.1.13.11.31

  PDB code Protein
1lox
Rabbit reticulocyte 15-lipoxygenase
Source: Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986. Cell: reticulocyte. Cellular_location: cytoplasm
Chain: A (647 residues) CATH domains: 1.20.245.10 2.60.60.20 3.10.450.60
Bound ligand:   Het Group RS7 is 86.00% similar to enzyme reactant Arachidonate
2abu
Human 12-lipoxygenase
Source: Homo sapiens. Human
Chain: A (662 residues)
2p0m
Revised structure of rabbit reticulocyte 15s-lipoxygenase
Source: Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986
Chains: A, B (662 residues) CATH domains: 2.60.60.20 1.20.245.10 3.10.450.60
Bound ligand:   Het Group RS7 is 86.36% similar to enzyme reactant Arachidonate
3d3l
The 2.6 a crystal structure of the lipoxygenase domain of human arachidonate 12-lipoxygenase, 12s-type (casp target)
Source: Homo sapiens. Organism_taxid: 9606. Gene: alox12, log12. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (451 residues) CATH domain: 1.20.245.10
3rde
Crystal structure of the catalytic domain of porcine leukocy lipoxygenase
Source: Sus scrofa. Pigs,swine,wild boar. Organism_taxid: 9823. Gene: alox12. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (552 residues) CATH domain: 1.20.245.10
Bound ligand:   Het Group OYP is 41.18% similar to enzyme reactant Arachidonate