_EC 1.13.11.11 Tryptophan 2,3-dioxygenase. 11 PDB entries  
EC 1.-.-.- Oxidoreductases. [9,068 PDB entries]
EC 1.13.-.- Acting on single donors with incorporation of molecular oxygen. [316 PDB entries]
EC 1.13.11.- With incorporation of two atoms of oxygen. [281 PDB entries]
EC 1.13.11.11 Tryptophan 2,3-dioxygenase. [11 PDB entries]    
1yw0

Pathway: Tryptophan Catabolism
Reaction: L-tryptophan + O(2) = N-formyl-L-kynurenine.
 


L-tryptophan
+
O(2)
=
N-formyl-L-kynurenine
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Indolamine 2,3-dioxygenase. Indoleamine 2,3-dioxygenase. L-tryptophan 2,3-dioxygenase. L-tryptophan pyrrolase. Tryptamin 2,3-dioxygenase. Tryptamine 2,3-dioxygenase. Tryptophan oxygenase. Tryptophan peroxidase. Tryptophan pyrrolase. Tryptophanase.
Cofactor(s): Heme.
 

Heme
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Comments: Catalyzes, together with Ec 1.13.11.52, the first and rate-limiting step in the kynurenine pathway, the major pathway of tryptophan metabolism. Specific for tryptophan as substrate, but is far more active with L-tryptophan than with D-tryptophan. Formerly Ec 1.11.1.4 and Ec 1.13.1.12.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 11 PDB entries in enzyme class E.C.1.13.11.11

  PDB code Protein
1yw0
Crystal structure of the tryptophan 2,3-dioxygenase from xanthomonas campestris. Northeast structural genomics target xcr13.
Source: Xanthomonas campestris pv. Campestris str. Atcc 33913. Organism_taxid: 190485. Strain: pv. Campestris str. Atcc 33913. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (243 residues) CATH domain: Unassigned
1zee
X-ray crystal structure of protein so4414 from shewanella on northeast structural genomics consortium target sor52.
Source: Shewanella oneidensis. Organism_taxid: 211586. Strain: mr-1. Gene: geneid:1172013. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (363 residues) CATH domains: Unassigned Unassigned
2nox
Crystal structure of tryptophan 2,3-dioxygenase from ralston metallidurans
Source: Cupriavidus metallidurans. Organism_taxid: 119219
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P (261 residues)
Bound ligand:   Het Group HEM is 95.45% similar to enzyme cofactor Protoheme
2nw7
Crystal structure of tryptophan 2,3-dioxygenase (tdo) from xanthomonas campestris in complex with ferric heme. Northeast structural genomics target xcr13
Source: Xanthomonas campestris pv. Campestris. Organism_taxid: 340. Strain: pv. Campestris. Atcc: 33913. Gene: xcc0432. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (259 residues) CATH domain: Unassigned
Bound ligand:   Het Group HEM is 95.00% similar to enzyme cofactor Protoheme IX
2nw8
Crystal structure of tryptophan 2,3-dioxygenase (tdo) from x campestris in complex with ferrous heme and tryptophan. Nor structural genomics target xcr13.
Source: Xanthomonas campestris pv. Campestris. Organism_taxid: 340. Strain: pv. Campestris. Atcc: 33913. Gene: xcc0432. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (266 residues)
Bound ligands:   Het Group TRP corresponds to enzyme reactant L-tryptophan
  Het Group HEM is 95.45% similar to enzyme cofactor Protoheme
2nw9
Crystal structure of tryptophan 2,3-dioxygenase (tdo) from x campestris in complex with ferrous heme and 6-fluoro-trypto northeast structural genomics target xcr13
Source: Xanthomonas campestris pv. Campestris. Organism_taxid: 340. Strain: pv. Campestris. Atcc: 33913. Gene: xcc0432. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (265 residues)
Bound ligands:   Het Group FT6 is 93.75% similar to enzyme reactant L-tryptophan
  Het Group HEM is 95.45% similar to enzyme cofactor Protoheme
2nwb
Crystal structure of a putative 2,3-dioxygenase (so4414) fro shewanella oneidensis in complex with ferric heme. Northeas structural genomics target sor52.
Source: Shewanella oneidensis. Organism_taxid: 211586. Strain: mr-1. Gene: so_4414. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (379 residues) CATH domains: Unassigned Unassigned
3bk9
H55a mutant of tryptophan 2,3-dioxygenase from xanthomonas campestris
Source: Xanthomonas campestris pv. Campestris. Organism_taxid: 340. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F, G, H (277 residues) CATH domain: Unassigned
Bound ligands:   Het Group TRP corresponds to enzyme reactant L-tryptophan
  Het Group HEM is 95.00% similar to enzyme cofactor Protoheme IX
3e08
H55s mutant xanthomonas campestris tryptophan 2,3- dioxygenase
Source: Xanthomonas campestris pv. Campestris. Organism_taxid: 340. Gene: xccb100_0466. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F, G, H (280 residues) CATH domain: Unassigned
Bound ligands:   Het Group TRP corresponds to enzyme reactant L-tryptophan
  Het Group HEM is 95.00% similar to enzyme cofactor Protoheme IX
4hka
Crystal structure of drosophila melanogaster tryptophan 2,3- dioxygenase in complex with heme
Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Gene: v, cg5163. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (345 residues) CATH domains: Unassigned Unassigned
4pw8
Human tryptophan 2,3-dioxygenase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tdo, tdo2. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D, E, F, G, H (306 residues) CATH domains: Unassigned Unassigned