_EC 1.12.2.1 Cytochrome-c3 hydrogenase. 25 PDB entries  
EC 1.-.-.- Oxidoreductases. [8,596 PDB entries]
EC 1.12.-.- Acting on hydrogen as donor. [67 PDB entries]
EC 1.12.2.- With a cytochrome as acceptor. [25 PDB entries]
EC 1.12.2.1 Cytochrome-c3 hydrogenase. [25 PDB entries]    
1frf

Reaction: 2 H(2) + ferricytochrome c3 = 4 H(+) + ferrocytochrome c3.
Other name(s): Cytochrome c3 reductase. Cytochrome hydrogenase. H(2):ferricytochrome c3 oxidoreductase.
Cofactor(s): Iron-sulfur; Nickel.
 

Iron-sulfur
Nickel
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Comments: Some forms of the enzyme contain nickel ([NiFe]-hydrogenases) and, of these, some contain selenocysteine ([NiFeSe]-hydrogenases). Methylene blue and other acceptors can also be reduced.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 25 PDB entries in enzyme class E.C.1.12.2.1

  PDB code Protein
1frf
Crystal structure of the ni-fe hydrogenase from desulfovibri fructosovorans
Source: Desulfovibrio fructosovorans. Organism_taxid: 878. Strain: wild type. Cellular_location: periplasm. Other_details: dsm 3604. Other_details: dsm 3604
Chains: S, L (261 residues) CATH domains: 3.40.50.700 4.10.480.10
1frv
Crystal structure of the oxidized form of ni-fe hydrogenase
Source: Desulfovibrio gigas. Organism_taxid: 879. Atcc: 19364. Atcc: 19364
Chains: A, B, C, D (262 residues) CATH domains: 3.40.50.700 4.10.480.10
1h2a
Single crystals of hydrogenase from desulfovibrio vulgaris
Source: Desulfovibrio vulgaris str. 'Miyazaki f'. Organism_taxid: 883. Strain: miyazaki f. Other_details: iam 12604. Other_details: iam 12604
Chain: L (534 residues) CATH domain: 1.10.645.10
1h2r
Three-dimensional structure of ni-fe hydrogenase from desulfivibrio vulgaris miyazaki f in the reduced form at 1.4 a resolution
Source: Desulfovibrio vulgaris str. 'Miyazaki f'. Organism_taxid: 883. Strain: miyazaki f. Atcc: iam 12604. Collection: iam 12604. Cellular_location: periplasmic membrane. Cellular_location: periplasmic membrane
Chains: S, L (267 residues) CATH domains: 3.40.50.700 4.10.480.10
1ubh
Three-dimensional structure of the carbon monoxide complex of [nife]hydrogenase from desulufovibrio vulgaris miyazaki f
Source: Desulfovibrio vulgaris str. 'Miyazaki f'. Organism_taxid: 883. Strain: miyazaki f. Strain: miyazaki f
Chain: S (267 residues) CATH domains: 3.40.50.700 4.10.480.10
1ubj
Three-dimensional structure of the carbon monoxide complex of [nife]hydrogenase from desulufovibrio vulgaris miyazaki f
Source: Desulfovibrio vulgaris str. 'Miyazaki f'. Organism_taxid: 883. Strain: miyazaki f. Strain: miyazaki f
Chain: S (267 residues) CATH domains: 3.40.50.700 4.10.480.10
1ubk
Three-dimensional structure of the carbon monoxide complex of [nife]hydrogenase from desulufovibrio vulgaris miyazaki f
Source: Desulfovibrio vulgaris str. 'Miyazaki f'. Organism_taxid: 883. Strain: miyazaki f. Strain: miyazaki f
Chains: S, L (267 residues) CATH domains: 3.40.50.700 4.10.480.10
1ubl
Three-dimensional structure of the carbon monoxide complex of [nife]hydrogenase from desulufovibrio vulgaris miyazaki f
Source: Desulfovibrio vulgaris str. 'Miyazaki f'. Organism_taxid: 883. Strain: miyazaki f. Strain: miyazaki f
Chains: S, L (267 residues) CATH domains: 3.40.50.700 4.10.480.10
1ubm
Three-dimensional structure of the carbon monoxide complex of [nife]hydrogenase from desulufovibrio vulgaris miyazaki f
Source: Desulfovibrio vulgaris str. 'Miyazaki f'. Organism_taxid: 883. Strain: miyazaki f. Strain: miyazaki f
Chain: L (534 residues) CATH domain: 1.10.645.10
1ubo
Three-dimensional structure of the carbon monoxide complex of [nife]hydrogenase from desulufovibrio vulgaris miyazaki f
Source: Desulfovibrio vulgaris str. 'Miyazaki f'. Organism_taxid: 883. Strain: miyazaki f. Strain: miyazaki f
Chains: S, L (267 residues) CATH domains: 3.40.50.700 4.10.480.10
1ubr
Three-dimensional structure of the carbon monoxide complex of [nife]hydrogenase from desulufovibrio vulgaris miyazaki f
Source: Desulfovibrio vulgaris str. 'Miyazaki f'. Organism_taxid: 883. Strain: miyazaki f. Strain: miyazaki f
Chain: S (267 residues) CATH domains: 3.40.50.700 4.10.480.10
1ubt
Three-dimensional structure of the carbon monoxide complex of [nife]hydrogenase from desulufovibrio vulgaris miyazaki f
Source: Desulfovibrio vulgaris str. 'Miyazaki f'. Organism_taxid: 883. Strain: miyazaki f. Strain: miyazaki f
Chains: S, L (267 residues) CATH domains: 3.40.50.700 4.10.480.10
1ubu
Three-dimensional structure of the carbon monoxide complex o [nife]hydrogenase from desulufovibrio vulgaris miyazaki f
Source: Desulfovibrio vulgaris str. 'Miyazaki organism_taxid: 883. Strain: miyazaki f. Strain: miyazaki f
Chains: S, L (267 residues) CATH domains: 3.40.50.700 4.10.480.10
1wuh
Three-dimensional structure of the ni-a state of [nife]hydrogenase from desulufovibrio vulgaris miyazaki f
Source: Desulfovibrio vulgaris str. 'Miyazaki f'. Organism_taxid: 883. Strain: miyazaki f. Strain: miyazaki f
Chains: S, L (267 residues) CATH domains: 3.40.50.700 4.10.480.10
1wui
Ultra-high resolution structure of the ni-a state of [nife]hydrogenase from desulufovibrio vulgaris miyazaki f
Source: Desulfovibrio vulgaris str. 'Miyazaki f'. Organism_taxid: 883. Strain: miyazaki f. Strain: miyazaki f
Chains: S, L (267 residues) CATH domains: 3.40.50.700 4.10.480.10
1wuj
Three-dimensional structure of the ni-b state of [nife]hydrogenase from desulufovibrio vulgaris miyazaki f
Source: Desulfovibrio vulgaris str. 'Miyazaki f'. Organism_taxid: 883. Strain: miyazaki f. Strain: miyazaki f
Chains: S, L (267 residues) CATH domains: 3.40.50.700 4.10.480.10
1wuk
High resolution structure of the oxidized state of [nife]hydrogenase from desulufovibrio vulgaris miyazaki f
Source: Desulfovibrio vulgaris str. 'Miyazaki f'. Organism_taxid: 883. Strain: miyazaki f. Strain: miyazaki f
Chains: S, L (267 residues) CATH domains: 3.40.50.700 4.10.480.10
1wul
High resolution structure of the reduced state of [nife]hydrogenase from desulufovibrio vulgaris miyazaki f
Source: Desulfovibrio vulgaris str. 'Miyazaki f'. Organism_taxid: 883. Strain: miyazaki f. Strain: miyazaki f
Chain: L (534 residues) CATH domain: 1.10.645.10
1yq9
Structure of the unready oxidized form of [nife] hydrogenase
Source: Desulfovibrio gigas. Organism_taxid: 879. Strain: wild type. Cellular_location: periplasm. Cellular_location: periplasm
Chains: A, B, I (261 residues) CATH domains: 3.40.50.700 4.10.480.10
1yqw
Structure of the oxidized unready form of ni-fe hydrogenase
Source: Desulfovibrio fructosovorans. Organism_taxid: 878. Strain: wild type. Cellular_location: periplasm. Cellular_location: periplasm
Chains: A, Q, B, R, C, S (262 residues) CATH domains: 3.40.50.700 4.10.480.10
1yrq
Structure of the ready oxidized form of [nife]-hydrogenase
Source: Desulfovibrio fructosovorans. Organism_taxid: 878. Strain: wild type. Cellular_location: periplasm. Cellular_location: periplasm
Chains: A, B, I, J, D, K, F, M, G (262 residues) CATH domains: 3.40.50.700 4.10.480.10
2frv
Crystal structure of the oxidized form of ni-fe hydrogenase
Source: Desulfovibrio gigas. Organism_taxid: 879. Collection: atcc 19364. Cellular_location: periplasm. Cellular_location: periplasm
Chains: S, L, A, D, F, G, H, I, J (261 residues) CATH domains: 3.40.50.700 4.10.480.10
3cur
Structure of a double methionine mutant of ni-fe hydrogenase
Source: Desulfovibrio fructosovorans. Organism_taxid: 878. Strain: wild type. Gene: hyda. Expressed in: desulfovibrio fructosovorans. Expression_system_taxid: 878. Gene: hydb. Expression_system_taxid: 878
Chains: A, H, B, I, C (262 residues) CATH domains: 3.40.50.700 4.10.480.10
3cus
Structure of a double ile/phe mutant of ni-fe hydrogenase re 2.2 angstrom resolution
Source: Desulfovibrio fructosovorans. Organism_taxid: 878. Strain: wild type. Gene: hyda. Expressed in: desulfovibrio fructosovorans. Expression_system_taxid: 878. Gene: hydb. Expression_system_taxid: 878
Chains: A, Q, B, R, C, S (262 residues) CATH domains: 3.40.50.700 4.10.480.10
3h3x
Structure of the v74m large subunit mutant of ni-fe hydrogen oxidized state
Source: Desulfovibrio fructosovorans. Organism_taxid: 878. Strain: dsm 3604. Gene: hyda. Expressed in: desulfovibrio fructosovorans. Expression_system_taxid: 878. Gene: hydb. Expression_system_taxid: 878
Chains: A, Q, B, R, C, S (262 residues) CATH domains: 3.40.50.700 4.10.480.10