_EC 1.10.3.2 Laccase. 58 PDB entries  
EC 1.-.-.- Oxidoreductases. [8,663 PDB entries]
EC 1.10.-.- Acting on diphenols and related substances as donors. [209 PDB entries]
EC 1.10.3.- With oxygen as acceptor. [91 PDB entries]
EC 1.10.3.2 Laccase. [58 PDB entries]    
1a65

Reaction: 4 benzenediol + O(2) = 4 benzosemiquinone + 2 H(2)O.
 


4 × benzenediol
+
O(2)
= 4 × benzosemiquinone
+ 2 × H(2)O
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Urishiol oxidase.
Cofactor(s): Cu cation.
Comments: A group of multi-copper proteins of low specificity. Acts on both o- and p-quinols, and often acting also on aminophenols and phenylenediamine. The semiquinone may react further either enzymically or non- enzymically.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 58 PDB entries in enzyme class E.C.1.10.3.2

  PDB code Protein
1a65
Type-2 cu-depleted laccase from coprinus cinereus
Source: Coprinopsis cinerea. Organism_taxid: 5346. Expressed in: aspergillus oryzae. Expression_system_taxid: 5062
Chain: A (504 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
Bound ligand:   Het Group NAG is 57.14% similar to enzyme reactant benzenediol
1gw0
Crystal structure of laccase from melanocarpus albomyces in four copper form
Source: Melanocarpus albomyces. Organism_taxid: 204285
Chains: A, B (559 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
Bound ligands:   Het Group NAG is 57.14% similar to enzyme reactant benzenediol
  Het Group OXY corresponds to enzyme reactant O(2)
1gyc
Crystal structure determination at room temperature of a laccase from trametes versicolor in its oxidised form containing a full complement of copper ions
Source: Trametes versicolor. White-rot fungus. Organism_taxid: 5325. Atcc: 20869
Chain: A (499 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
Bound ligand:   Het Group NAG is 57.14% similar to enzyme reactant benzenediol
1hfu
Type-2 cu-depleted laccase from coprinus cinereus at 1.68 a resolution
Source: Coprinus cinereus. Inky cap fungus. Organism_taxid: 5346. Expressed in: aspergillus oryzae. Expression_system_taxid: 5062.
Chain: A (500 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
Bound ligand:   Het Group MAN is 72.73% similar to enzyme reactant benzenediol
1kya
Active laccase from trametes versicolor complexed with 2,5-x
Source: Trametes versicolor. Organism_taxid: 5325. Strain: atcc 32745
Chains: A, B, C, D (499 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
Bound ligand:   Het Group NAG is 57.14% similar to enzyme reactant benzenediol
1v10
Structure of rigidoporus lignosus laccase from hemihedrally twinned crystals
Source: Rigidoporus lignosus. Organism_taxid: 219653. Atcc: aj609490
Chain: A (487 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
2h5u
Crystal structure of laccase from cerrena maxima at 1.9a res
Source: Trametes maxima. Organism_taxid: 259368. Strain: 0275 (mont)kraisel of the polyporaceae family
Chain: A (499 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
Bound ligand:   Het Group NAG is 57.14% similar to enzyme reactant benzenediol
2hzh
Crystal structure of laccase from coriolus zonatus at 2.6 a
Source: Trametes ochracea. Organism_taxid: 230624
Chain: A (499 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
Bound ligand:   Het Group NDG is 53.33% similar to enzyme reactant benzenediol
2ih8
A low-dose crystal structure of a recombinant melanocarpus a laccase
Source: Melanocarpus albomyces. Organism_taxid: 204285. Strain: vtt d-96490. Gene: lac1. Expressed in: hypocrea jecorina. Expression_system_taxid: 51453
Chains: A, B (559 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
Bound ligands:   Het Group NAG is 57.14% similar to enzyme reactant benzenediol
  Het Group OXY corresponds to enzyme reactant O(2)
2ih9
A high-dose crystal structure of a recombinant melanocarbus laccase
Source: Melanocarpus albomyces. Organism_taxid: 204285. Strain: vtt d-96490. Gene: lac1. Expressed in: hypocrea jecorina. Expression_system_taxid: 51453
Chains: A, B (559 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
Bound ligand:   Het Group NAG is 57.14% similar to enzyme reactant benzenediol
2q9o
Near-atomic resolution structure of a melanocarpus albomyces
Source: Melanocarpus albomyces. Organism_taxid: 204285. Strain: vtt d-96490. Gene: lac1. Expressed in: hypocrea jecorina. Expression_system_taxid: 51453.
Chains: A, B (559 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
Bound ligands:   Het Group NAG is 57.14% similar to enzyme reactant benzenediol
  Het Group OXY corresponds to enzyme reactant O(2)
2qt6
Crystal structure determination of a blue laccase from lenti tigrinus
Source: Lentinus tigrinus. Organism_taxid: 5365. Strain: 8/18
Chains: A, B (498 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
Bound ligands:   Het Group BMA is 72.73% similar to enzyme reactant benzenediol
  Het Group PER corresponds to enzyme reactant O(2)
2vds
Crystal structure of laccase from coriolopsis gallica
Source: Coriolopsis gallica. Organism_taxid: 76126
Chain: A (496 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
Bound ligand:   Het Group NAG is 57.14% similar to enzyme reactant benzenediol
2vdz
Crystal structure of a coriolopsis gallica laccase at 1.7 a resolution
Source: Coriolopsis gallica. Organism_taxid: 76126
Chain: A (496 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
Bound ligand:   Het Group NAG is 57.14% similar to enzyme reactant benzenediol
2ve0
Coriolopsis gallica laccase t2 copper depleted
Source: Coriolopsis gallica. Organism_taxid: 76126
Chain: A (493 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
Bound ligand:   Het Group NAG is 57.14% similar to enzyme reactant benzenediol
2xu9
Crystal structure of laccase from thermus thermophilus hb27
Source: Thermus thermophilus. Organism_taxid: 262724. Strain: hb27. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (439 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
Bound ligand:   Het Group MPD is 60.00% similar to enzyme reactant benzenediol
2xuw
Crystal structure of apolaccase from thermus thermophilus hb
Source: Thermus thermophilus. Organism_taxid: 262724. Strain: hb27. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (439 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
Bound ligand:   Het Group MPD is 77.78% similar to enzyme reactant benzenediol
2xvb
Crystal structure of laccase from thermus thermophilus hb27 complexed with hg, crystal of the apoenzyme soaked for 5 min. In 5 mm hgcl2 at 278 k.
Source: Thermus thermophilus. Organism_taxid: 262724. Strain: hb27. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (439 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
Bound ligand:   Het Group MPD is 77.78% similar to enzyme reactant benzenediol
2xyb
Crystal structure of a fully functional laccase from the ligninolytic fungus pycnoporus cinnabarinus
Source: Pycnoporus cinnabarinus. Organism_taxid: 5643. Strain: ss3. Other_details: this organism is also known as cinnabar-red
Chain: A (497 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
Bound ligands:   Het Group NAG is 57.14% similar to enzyme reactant benzenediol
  Het Group PER corresponds to enzyme reactant O(2)
2yae
X-ray induced reduction of laccase from thermus thermophilus hb27(0.0-12.5 percent dose)
Source: Thermus thermophilus. Organism_taxid: 262724. Strain: hb27. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (439 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
Bound ligands:   Het Group MPD is 60.00% similar to enzyme reactant benzenediol
  Het Group OXY corresponds to enzyme reactant O(2)
2yaf
X-ray induced reduction of laccase from thermus thermophilus (12.5-25.0 percent dose)
Source: Thermus thermophilus. Organism_taxid: 262724. Strain: hb27. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (439 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
Bound ligand:   Het Group MPD is 60.00% similar to enzyme reactant benzenediol
2yah
X-ray induced reduction of laccase from thermus thermophilus (25.0-37.5 percent dose)
Source: Thermus thermophilus. Organism_taxid: 262724. Strain: hb27. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (439 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
Bound ligand:   Het Group MPD is 60.00% similar to enzyme reactant benzenediol
2yam
X-ray induced reduction of laccase from thermus thermophilus (37.5-50.0 percent dose)
Source: Thermus thermophilus. Organism_taxid: 262724. Strain: hb27. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (439 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
Bound ligand:   Het Group MPD is 60.00% similar to enzyme reactant benzenediol
2yao
X-ray induced reduction of laccase from thermus thermophilus (50.0-62.5 percent dose)
Source: Thermus thermophilus. Organism_taxid: 262724. Strain: hb27. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (439 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
Bound ligand:   Het Group MPD is 60.00% similar to enzyme reactant benzenediol
2yap
X-ray induced reduction of laccase from thermus thermophilus (62.5-75.0 percent dose)
Source: Thermus thermophilus. Organism_taxid: 262724. Strain: hb27. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (439 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
Bound ligand:   Het Group MPD is 60.00% similar to enzyme reactant benzenediol
2yaq
X-ray induced reduction of laccase from thermus thermophilus (75.0-87.5 percent dose)
Source: Thermus thermophilus. Organism_taxid: 262724. Strain: hb27. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (439 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
Bound ligand:   Het Group MPD is 60.00% similar to enzyme reactant benzenediol
2yar
X-ray induced reduction of laccase from thermus thermophilus (87.5-100.0 percent dose)
Source: Thermus thermophilus. Organism_taxid: 262724. Strain: hb27. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (439 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
Bound ligand:   Het Group MPD is 60.00% similar to enzyme reactant benzenediol
3div
Crystal structure of laccase from cerrena maxima at 1.76a re
Source: Cerrena. Organism_taxid: 90311
Chain: A (499 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
Bound ligand:   Het Group NAG is 57.14% similar to enzyme reactant benzenediol
3dkh
L559a mutant of melanocarpus albomyces laccase
Source: Melanocarpus albomyces. Organism_taxid: 204285. Strain: vtt d-96490. Gene: lac1. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932.
Chains: A, B (558 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
Bound ligands:   Het Group NAG is 57.14% similar to enzyme reactant benzenediol
  Het Group OXY corresponds to enzyme reactant O(2)
3fpx
Native fungus laccase from trametes hirsuta
Source: Trametes hirsuta. White-rot fungus. Organism_taxid: 5327. Strain: 072-1. Other_details: cultural liquid
Chain: A (499 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
Bound ligand:   Het Group NAG is 57.14% similar to enzyme reactant benzenediol
3fu7
Melanocarpus albomyces laccase crystal soaked (4 sec) with 2 dimethoxyphenol
Source: Melanocarpus albomyces. Organism_taxid: 204285. Strain: vtt d-96490. Gene: lac1. Expressed in: trichoderma reesei. Expression_system_taxid: 51453.
Chains: A, B (559 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
Bound ligands:   Het Group NAG is 57.14% similar to enzyme reactant benzenediol
  Het Group OXY corresponds to enzyme reactant O(2)
3fu8
Melanocarpus albomyces laccase crystal soaked (10 sec) with dimethoxyphenol
Source: Melanocarpus albomyces. Organism_taxid: 204285. Strain: vtt d-96490. Gene: lac1. Expressed in: trichoderma reesei. Expression_system_taxid: 51453.
Chains: A, B (559 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
Bound ligand:   Het Group NAG is 57.14% similar to enzyme reactant benzenediol
3fu9
Melanocarpus albomyces laccase crystal soaked (20 min) with dimethoxyphenol
Source: Melanocarpus albomyces. Organism_taxid: 204285. Strain: vtt d-96490. Gene: lac1. Expressed in: trichoderma reesei. Expression_system_taxid: 51453.
Chains: A, B (559 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
Bound ligand:   Het Group NAG is 57.14% similar to enzyme reactant benzenediol
3kw7
Crystal structure of lacb from trametes sp. Ah28-2
Source: Trametes. Organism_taxid: 306582. Strain: ah28-2
Chains: A, B (502 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
Bound ligand:   Het Group NAG is 57.14% similar to enzyme reactant benzenediol
3pps
Crystal structure of an ascomycete fungal laccase from thiel arenaria
Source: Thielavia arenaria. Organism_taxid: 113610. Expressed in: trichoderma reesei. Expression_system_taxid: 431241
Chains: A, B, C, D (564 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
Bound ligands:   Het Group NAG is 57.14% similar to enzyme reactant benzenediol
  Het Group OXY corresponds to enzyme reactant O(2)
3pxl
Type-2 cu-depleted fungus laccase from trametes hirsuta
Source: Trametes hirsuta. White-rot fungus. Organism_taxid: 5327
Chain: A (499 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
Bound ligand:   Het Group NAG is 57.14% similar to enzyme reactant benzenediol
3qpk
Probing oxygen channels in melanocarpus albomyces laccase
Source: Melanocarpus albomyces. Organism_taxid: 204285. Gene: lac1. Expressed in: hypocrea jecorina. Expression_system_taxid: 51453
Chains: A, B (559 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
Bound ligand:   Het Group NAG is 57.14% similar to enzyme reactant benzenediol
3t6v
Crystal structure of laccase from steccherinum ochraceum
Source: Steccherinum ochraceum. Organism_taxid: 92696. Strain: 1833
Chains: A, B, C (495 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
3t6w
Crystal structure of steccherinum ochraceum laccase obtained crystals composite data collection technique (10% dose)
Source: Steccherinum ochraceum. Organism_taxid: 92696. Strain: 1833
Chains: A, B, C (495 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
Bound ligands:   Het Group GOL is 55.56% similar to enzyme reactant benzenediol
  Het Group OXY corresponds to enzyme reactant O(2)
3t6x
Crystal structure of steccherinum ochraceum laccase obtained crystals composite data collection technique (20% dose)
Source: Steccherinum ochraceum. Organism_taxid: 92696. Strain: 1833
Chains: A, B, C (495 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
3t6z
Crystal structure of steccherinum ochraceum laccase obtained crystals composite data collection technique (60% dose)
Source: Steccherinum ochraceum. Organism_taxid: 92696. Strain: 1833
Chains: A, B, C (495 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
3t71
Crystal structure of steccherinum ochraceum laccase obtained crystals composite data collection technique (90% dose)
Source: Steccherinum ochraceum. Organism_taxid: 92696. Strain: 1833
Chains: A, B, C (495 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
3t9w
Small laccase from amycolatopsis sp. Atcc 39116
Source: Amycolatopsis sp. Atcc 39116. Organism_taxid: 385957. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (270 residues) CATH domains: 2.60.40.420 2.60.40.420
Bound ligand:   Het Group PEO corresponds to enzyme reactant O(2)
3ta4
Small laccase from amycolatopsis sp. Atcc 39116 complexed wi dimethoxyphenyl)-2-(2-methoxyphenoxy)-1,3-dihydroxypropane
Source: Amycolatopsis sp. Atcc 39116. Organism_taxid: 385957. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: F, D, E (282 residues) CATH domains: 2.60.40.420 2.60.40.420
3tas
Small laccase from streptomyces viridosporus t7a
Source: Streptomyces viridosporus. Organism_taxid: 67581. Strain: t7a. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (300 residues) CATH domains: 2.60.40.420 2.60.40.420
Bound ligand:   Het Group OXY corresponds to enzyme reactant O(2)
3tbb
Small laccase from streptomyces viridosporus t7a; alternate form.
Source: Streptomyces viridosporus. Organism_taxid: 67581. Strain: t7a. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (279 residues) CATH domains: 2.60.40.420 2.60.40.420
Bound ligand:   Het Group OXY corresponds to enzyme reactant O(2)
3tbc
Small laccase from streptomyces viridosporus t7a; alternate form complexed with acetovanillone.
Source: Streptomyces viridosporus. Organism_taxid: 67581. Strain: t7a. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (279 residues) CATH domains: 2.60.40.420 2.60.40.420
Bound ligands:   Het Group I75 is 66.67% similar to enzyme reactant benzenediol
  Het Group OXY corresponds to enzyme reactant O(2)
3v9c
Type-2 cu-depleted fungus laccase from trametes hirsuta at l ionization radiation
Source: Trametes hirsuta. White-rot fungus. Organism_taxid: 5327
Chain: A (499 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
3v9e
Structure of the l513m mutant of the laccase from b.Aclada
Source: Botrytis aclada. Organism_taxid: 139639. Expressed in: pichia pastoris. Expression_system_taxid: 4922
Chain: A (539 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
Bound ligand:   Het Group NAG is 57.14% similar to enzyme reactant benzenediol
4a2d
Coriolopsis gallica laccase t2 copper depleted at ph 4.5
Source: Coriolopsis gallica. Organism_taxid: 76126
Chain: A (496 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
Bound ligand:   Het Group NAG is 57.14% similar to enzyme reactant benzenediol
4a2e
Crystal structure of a coriolopsis gallica laccase at 1.7 a resolution ph 5.5
Source: Coriolopsis gallica. Organism_taxid: 76126
Chain: A (496 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
Bound ligand:   Het Group NAG is 57.14% similar to enzyme reactant benzenediol
4a2f
Coriolopsis gallica laccase collected at 12.65 kev
Source: Coriolopsis gallica. Organism_taxid: 76126
Chain: A (496 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
Bound ligand:   Het Group NAG is 57.14% similar to enzyme reactant benzenediol
4a2g
Coriolopsis gallica laccase collected at 8.98 kev
Source: Coriolopsis gallica. Organism_taxid: 76126
Chain: A (496 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
Bound ligand:   Het Group NAG is 57.14% similar to enzyme reactant benzenediol
4a2h
Crystal structure of laccase from coriolopsis gallica ph 7.0
Source: Coriolopsis gallica. Organism_taxid: 76126
Chain: A (496 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
Bound ligand:   Het Group NAG is 57.14% similar to enzyme reactant benzenediol
4ai7
Crystal structure of laccase from thermus thermophilus hb27 complexed with hg, crystal of the apoenzyme soaked for 2 h in 5 mm hgcl2 at 278 k.
Source: Thermus thermophilus. Organism_taxid: 262724. Strain: hb27. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (439 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
4f7k
Crystal structure of lac15 from a marine microbial metagenom
Source: Uncultured bacterium. Organism_taxid: 77133. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (377 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
Bound ligand:   Het Group GOL is 55.56% similar to enzyme reactant benzenediol
4jhu
T2-depleted laccase from coriolopsis caperata soaked with cu
Source: Coriolopsis caperata. Organism_taxid: 195176
Chain: A (496 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420
4jhv
T2-depleted laccase from coriolopsis caperata
Source: Coriolopsis caperata. Organism_taxid: 195176
Chain: A (496 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420