_EC 1.1.4.2 Vitamin-K-epoxide reductase (warfarin-insensitive). 0 PDB entries  
EC 1.-.-.- Oxidoreductases. [3,392 PDB entries]
EC 1.1.-.- Acting on the CH-OH group of donors. [697 PDB entries]
EC 1.1.4.- With a disulfide as acceptor. [-]
EC 1.1.4.2 Vitamin-K-epoxide reductase (warfarin-insensitive). [-]    

Reaction: 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4- naphthoquinone + 1,4-dithiothreitol.
 


3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone
+
oxidized dithiothreitol
=
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4- naphthoquinone
+
1,4-dithiothreitol
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Vitamin K 2,3-epoxide reductase.
Comments: In the reverse reaction, vitamin K 2,3-epoxide is reduced to 3-hydroxy- (and 2-hydroxy-) vitamin K by 1,4-dithioerythritol, which is oxidized to a disulfide. Not inhibited by warfarin (cf. Ec 1.1.4.1).
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are no PDB entries in enzyme class E.C.1.1.4.2