_EC 1.1.3.15 (S)-2-hydroxy-acid oxidase. 11 PDB entries  
EC 1.-.-.- Oxidoreductases. [8,653 PDB entries]
EC 1.1.-.- Acting on the CH-OH group of donors. [1,874 PDB entries]
EC 1.1.3.- With oxygen as acceptor. [120 PDB entries]
EC 1.1.3.15 (S)-2-hydroxy-acid oxidase. [11 PDB entries]    
1al7

Reaction: (S)-2-hydroxy acid + O(2) = 2-oxo acid + H(2)O(2).
 


(S)-2-hydroxy acid
+
O(2)
=
2-oxo acid
+
H(2)O(2)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Glycolate oxidase. Hydroxy-acid oxidase A. Hydroxy-acid oxidase B.
Cofactor(s): Fmn.
 

FMN
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Comments: Exists as two major isoenzymes; the A form preferentially oxidizes short-chain aliphatic hydroxy acids; the B form preferentially oxidizes long-chain and aromatic hydroxy acids. The rat isoenzyme B also acts as ec 1.4.3.2. Formerly Ec 1.1.3.1.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 11 PDB entries in enzyme class E.C.1.1.3.15

  PDB code Protein
1al7
Three-dimensional structures of glycolate oxidase with bound site inhibitors
Source: Spinacia oleracea. Spinach. Organism_taxid: 3562. Cell_line: bl21. Cellular_location: peroxisome. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (350 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group FMN corresponds to enzyme cofactor FMN
1al8
Three-dimensional structure of glycolate oxidase with bound site inhibitors
Source: Spinacia oleracea. Spinach. Organism_taxid: 3562. Cell_line: bl21. Cellular_location: peroxisome. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (344 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group FMN corresponds to enzyme cofactor FMN
1gox
Refined structure of spinach glycolate oxidase at 2 angstrom resolution
Source: Spinacia oleracea. Spinach. Organism_taxid: 3562
Chain: A (351 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group FMN corresponds to enzyme cofactor FMN
1gyl
Involvement of tyr24 and trp108 in substrate binding and substrate specificity of glycolate oxidase
Source: Spinacia oleracea. Spinach. Organism_taxid: 3562. Gene: glycolate oxidase from spinach. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (352 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group FMN corresponds to enzyme cofactor FMN
1tb3
Crystal structure analysis of recombinant rat kidney long- chain hydroxy acid oxidase
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: hao3, haox3. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D, E, F, G, H (332 residues) CATH domain: 3.20.20.70
Bound ligands:   Het Group ACY is 66.00% similar to enzyme reactant (S)-2-hydroxy acid
  Het Group FMN corresponds to enzyme cofactor FMN
2nzl
Crystal structure of human hydroxyacid oxidase 1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hao1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (339 residues) CATH domain: 3.20.20.70
Bound ligands:   Het Group GLV is 83.33% similar to enzyme reactant (S)-2-hydroxy
  Het Group FMN corresponds to enzyme cofactor FMN
2rdt
Crystal structure of human glycolate oxidase (go) in complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hao1, gox1, haox1. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: c41(de3).
Chain: A (335 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group FMN corresponds to enzyme cofactor FMN
2rdu
Crystal structure of human glycolate oxidase in complex with glyoxylate
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hao1, gox1, haox1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (360 residues) CATH domain: 3.20.20.70
Bound ligands:   Het Group GLV is 83.33% similar to enzyme reactant (S)-2-hydroxy
  Het Group FMN corresponds to enzyme cofactor FMN
2rdw
Crystal structure of human glycolate oxidase in complex with
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hao1, gox1, haox1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (359 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group FMN corresponds to enzyme cofactor FMN
2w0u
Crystal structure of human glycolate oxidase in complex with the inhibitor 5-[(4-chlorophenyl)sulfanyl]- 1,2,3-thiadiazole-4-carboxylate.
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: liver. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B, C, D (334 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group FMN corresponds to enzyme cofactor FMN
3sgz
High resolution crystal structure of rat long chain hydroxy oxidase in complex with the inhibitor 4-carboxy-5-[(4-chior sulfanyl]-1, 2, 3-thiadiazole.
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: hao2, hao3, haox2. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C (336 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group FMN corresponds to enzyme cofactor FMN