_EC 1.1.1.95 Phosphoglycerate dehydrogenase. 14 PDB entries  
EC 1.-.-.- Oxidoreductases. [8,653 PDB entries]
EC 1.1.-.- Acting on the CH-OH group of donors. [1,874 PDB entries]
EC 1.1.1.- With NAD(+) or NADP(+) as acceptor. [1,685 PDB entries]
EC 1.1.1.95 Phosphoglycerate dehydrogenase. [14 PDB entries]    
1psd

Reaction: (1) 3-phospho-D-glycerate + NAD(+) = 3-phosphonooxypyruvate + Nadh. (2) 2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + Nadh.
 


3-phospho-D-glycerate
+
NAD(+)
=
3-phosphonooxypyruvate
+
NADH

2-hydroxyglutarate
+
NAD(+)
=
2-oxoglutarate
+
NADH
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): 3-phosphoglycerate dehydrogenase. 3-phosphoglyceric acid dehydrogenase. 3PHP reductase. Alpha-KG reductase. Alpha-phosphoglycerate dehydrogenase. D-3-phosphoglycerate dehydrogenase. Glycerate 3-phosphate dehydrogenase. Glycerate-1,3-phosphate dehydrogenase. Pgdh. Phosphoglycerate oxidoreductase.
Comments: Catalyzes the first committed step in the phosphoserine pathway of serine biosynthesis in Escherichia coli. Reaction (1) occurs predominantly in the reverse direction and is inhibited by serine and glycine. The enzyme is unusual in that it also acts as a D- and L-2- hydroxyglutarate dehydrogenase (with the D-form being the better substrate) and as a 2-oxoglutarate reductase.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 14 PDB entries in enzyme class E.C.1.1.1.95

  PDB code Protein
1psd
The allosteric ligand site in the vmax-type cooperative enzy phosphoglycerate dehydrogenase
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12.
Chains: A, B (404 residues) CATH domains: 3.40.50.720 3.40.50.720 3.30.70.260
Bound ligands:   Het Group SER is 50.00% similar to enzyme reactant 3-phospho-D-glycerate
  Het Group NAD corresponds to enzyme reactant NAD(+)
  Het Group SER is 41.67% similar to enzyme reactant 2-hydroxyglutarate
  Het Group NAD corresponds to enzyme reactant NAD(+)
1sc6
Crystal structure of w139g d-3-phosphoglycerate dehydrogenase complexed with NAD+
Source: Escherichia coli. Organism_taxid: 562. Gene: sera, b2913, c3494, z4251, ecs3784, sf2898, s3098. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (390 residues) CATH domains: 3.40.50.720 3.40.50.720 3.30.70.260
Bound ligands:   Het Group NAD corresponds to enzyme reactant NAD(+)
  Het Group NAD corresponds to enzyme reactant NAD(+)
1yba
The active form of phosphoglycerate dehydrogenase
Source: Escherichia coli. Organism_taxid: 562. Gene: sera. Expressed in: escherichia coli k12. Expression_system_taxid: 83333.
Chains: A, B, C, D (406 residues) CATH domains: 3.40.50.720 3.40.50.720 3.30.70.260
Bound ligands:   Het Group AKG is 40.00% similar to enzyme reactant 3-phospho-D-glycerate
  Het Group NAD corresponds to enzyme reactant NAD(+)
  Het Group AKG corresponds to enzyme reactant 2-hydroxyglutarate
  Het Group NAD corresponds to enzyme reactant NAD(+)
1ygy
Crystal structure of d-3-phosphoglycerate dehydrogenase from mycobacterium tuberculosis
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: sera1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (527 residues) CATH domains: 3.40.50.720 3.40.50.720 3.30.1330.90 3.30.70.260
Bound ligands:   Het Group TAR is 50.00% similar to enzyme reactant 3-phospho-D-glycerate
  Het Group TAR is 53.85% similar to enzyme reactant 2-hydroxyglutarate
2ekl
Structure of st1218 protein from sulfolobus tokodaii
Source: Sulfolobus tokodaii. Organism_taxid: 111955. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (312 residues) CATH domains: 3.40.50.720 3.40.50.720
2g76
Crystal structure of human 3-phosphoglycerate dehydrogenase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: phgdh, pgdh3. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (302 residues) CATH domains: 3.40.50.720 3.40.50.720
Bound ligands:   Het Group MLT is 42.86% similar to enzyme reactant 3-phospho-D-glycerate
  Het Group NAD corresponds to enzyme reactant NAD(+)
  Het Group MLT is 58.33% similar to enzyme reactant 2-hydroxyglutarate
  Het Group NAD corresponds to enzyme reactant NAD(+)
2p9c
Crystal structure of serine bound g336v mutant of e.Coli phosphoglycerate dehydrogenase
Source: Escherichia coli. Organism_taxid: 562. Gene: sera. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (405 residues) CATH domains: 3.40.50.720 3.40.50.720 3.30.70.260
Bound ligands:   Het Group SER is 50.00% similar to enzyme reactant 3-phospho-D-glycerate
  Het Group NAI corresponds to enzyme reactant NAD(+)
  Het Group SER is 41.67% similar to enzyme reactant 2-hydroxyglutarate
  Het Group NAI corresponds to enzyme reactant NAD(+)
2p9e
Crystal structure of g336v mutant of e.Coli phosphoglycerate dehydrogenase
Source: Escherichia coli. Organism_taxid: 562. Gene: sera. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (406 residues) CATH domains: 3.40.50.720 3.40.50.720 3.30.70.260
Bound ligands:   Het Group PO4 is 45.00% similar to enzyme reactant 3-phospho-D-glycerate
  Het Group NAI corresponds to enzyme reactant NAD(+)
  Het Group CIT is 64.00% similar to enzyme reactant 2-hydroxyglutarate
  Het Group NAI corresponds to enzyme reactant NAD(+)
2p9g
Crystal structure of serine bound g336v,g337v double mutant phosphoglycerate dehydrogenase
Source: Escherichia coli. Organism_taxid: 562. Gene: sera. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (404 residues) CATH domains: 3.40.50.720 3.40.50.720 3.30.70.260
Bound ligands:   Het Group SER is 50.00% similar to enzyme reactant 3-phospho-D-glycerate
  Het Group NAI corresponds to enzyme reactant NAD(+)
  Het Group SER is 41.67% similar to enzyme reactant 2-hydroxyglutarate
  Het Group NAI corresponds to enzyme reactant NAD(+)
2pa3
Crystal structure of serine bound g336v mutant of e.Coli phosphoglycerate dehydrogenase
Source: Escherichia coli. Organism_taxid: 562. Gene: sera. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (406 residues) CATH domains: 3.40.50.720 3.40.50.720 3.30.70.260
Bound ligands:   Het Group SER is 41.67% similar to enzyme reactant 3-phospho-D-glycerate
  Het Group NAI corresponds to enzyme reactant NAD(+)
  Het Group NAI corresponds to enzyme reactant NAD(+)
3dc2
Crystal structure of serine bound d-3-phosphoglycerate dehyd from mycobacterium tuberculosis
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: h37rv. Gene: sera1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (526 residues) CATH domains: 3.40.50.720 3.40.50.720 3.30.1330.90 3.30.70.260
Bound ligands:   Het Group TLA is 50.00% similar to enzyme reactant 3-phospho-D-glycerate
  Het Group TLA is 53.85% similar to enzyme reactant 2-hydroxyglutarate
3ddn
Crystal structure of hydroxypyruvic acid phosphate bound d-3 phosphoglycerate dehydrogenase in mycobacterium tuberculosi
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: h37rv. Gene: sera1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (527 residues) CATH domains: 3.40.50.720 3.40.50.720 3.30.1330.90 3.30.70.260
Bound ligands:   Het Group HPV corresponds to enzyme reactant 3-phospho-D-glycerate
  Het Group TLA is 53.85% similar to enzyme reactant 2-hydroxyglutarate
3gg9
Crystal structure of putative d-3-phosphoglycerate dehydroge oxidoreductase from ralstonia solanacearum
Source: Ralstonia solanacearum. Pseudomonas solanacearum. Organism_taxid: 305. Gene: sera, rsc0016
Chains: A, B, C, D (342 residues) CATH domains: 3.40.50.720 3.40.50.720
Bound ligands:   Het Group GOL is 54.55% similar to enzyme reactant 3-phospho-D-glycerate
  Het Group GOL is 45.45% similar to enzyme reactant 2-hydroxyglutarate
3k5p
Crystal structure of amino acid-binding act: d-isomer specif hydroxyacid dehydrogenase catalytic domain from brucella me
Source: Brucella melitensis biovar abortus. Organism_taxid: 359391. Strain: biovar abortus 2308. Gene: bmeii0813. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (400 residues) CATH domains: 3.40.50.720 3.40.50.720 3.30.70.260
Bound ligands:   Het Group GOL is 54.55% similar to enzyme reactant 3-phospho-D-glycerate
  Het Group GOL is 45.45% similar to enzyme reactant 2-hydroxyglutarate