_EC 1.1.1.87 Homoisocitrate dehydrogenase. 5 PDB entries  
EC 1.-.-.- Oxidoreductases. [8,596 PDB entries]
EC 1.1.-.- Acting on the CH-OH group of donors. [1,875 PDB entries]
EC 1.1.1.- With NAD(+) or NADP(+) as acceptor. [1,681 PDB entries]
EC 1.1.1.87 Homoisocitrate dehydrogenase. [5 PDB entries]    
1x0l

Reaction: (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD(+) = 2-oxoadipate + CO(2) + Nadh.
 


(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate
+
NAD(+)
=
2-oxoadipate
+
CO(2)
+
NADH
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): (-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD(+) oxidoreductase (decarboxylating). 2-hydroxy-3-carboxyadipate dehydrogenase. 3-carboxy-2-hydroxyadipate dehydrogenase. 3-carboxy-2-hydroxyadipate:NAD(+) oxidoreductase (decarboxylating). Homoisocitric dehydrogenase.
Comments: Forms part of the lysine biosynthesis pathway in fungi. Formerly Ec 1.1.1.155.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 5 PDB entries in enzyme class E.C.1.1.1.87

  PDB code Protein
1x0l
Crystal structure of tetrameric homoisocitrate dehydrogenase extreme thermophile, thermus thermophilus
Source: Thermus thermophilus. Organism_taxid: 274. Gene: hicdh. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (333 residues) CATH domain: 3.40.718.10
3ah3
Crystal structure of lr5-1, 3-isopropylmalate dehydrogenase directed evolution
Source: Thermus thermophilus. Organism_taxid: 262724. Strain: hb27. Gene: lr5-1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: B, C, D ( residues)
3asj
Crystal structure of homoisocitrate dehydrogenase in complex designed inhibitor
Source: Thermus thermophilus. Organism_taxid: 274. Gene: hicd, hdh. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, D (333 residues) CATH domain: 3.40.718.10
Bound ligand:   Het Group MPD is 46.15% similar to enzyme product 2-oxoadipate
3ty3
Crystal structure of homoisocitrate dehydrogenase from schizosaccharomyces pombe bound to glycyl-glycyl-glycine
Source: Schizosaccharomyces pombe. Fission yeast. Organism_taxid: 284812. Strain: atcc 38366 / 972. Gene: lys12, spac31g5.04. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (358 residues) CATH domain: 3.40.718.10
Bound ligand:   Het Group GOL is 41.67% similar to enzyme product 2-oxoadipate
3ty4
Crystal structure of homoisocitrate dehydrogenase from schizosaccharomyces pombe
Source: Schizosaccharomyces pombe. Fission yeast. Organism_taxid: 284812. Strain: atcc 38366 / 972. Gene: lys12, spac31g5.04. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (356 residues) CATH domain: 3.40.718.10
Bound ligand:   Het Group GOL is 41.67% similar to enzyme product 2-oxoadipate