_EC 1.1.1.51 3(or 17)-beta-hydroxysteroid dehydrogenase. 7 PDB entries  
EC 1.-.-.- Oxidoreductases. [8,663 PDB entries]
EC 1.1.-.- Acting on the CH-OH group of donors. [1,873 PDB entries]
EC 1.1.1.- With NAD(+) or NADP(+) as acceptor. [1,684 PDB entries]
EC 1.1.1.51 3(or 17)-beta-hydroxysteroid dehydrogenase. [7 PDB entries]    
1e3s

Reaction: Testosterone + NAD(P)(+) = androst-4-ene-3,17-dione + NAD(P)H.
 


Testosterone
+
NAD(P)(+)
=
androst-4-ene-3,17-dione
+
NAD(P)H
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Comments: Also acts on other 3-beta- or 17-beta-hydroxysteroids (cf. Ec 1.1.1.209).
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 7 PDB entries in enzyme class E.C.1.1.1.51

  PDB code Protein
1e3s
Rat brain 3-hydroxyacyl-coa dehydrogenase binary complex with nadh
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Organ: brain. Organelle: mitochonria. Cellular_location: cytoplasm. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B, C, D (241 residues) CATH domain: 3.40.50.720
1e3w
Rat brain 3-hydroxyacyl-coa dehydrogenase binary complex with nadh and 3-keto butyrate
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Organ: brain. Organelle: mitochonria. Cellular_location: cytoplasm. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B, C, D (251 residues) CATH domain: 3.40.50.720
1e6w
Rat brain 3-hydroxyacyl-coa dehydrogenase binary complex with nadh and estradiol
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Organ: brain. Organelle: mitochonria. Cellular_location: cytoplasm. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B, C, D (251 residues) CATH domain: 3.40.50.720
1hxh
Comamonas testosteroni 3beta/17beta hydroxysteroid dehydrogenase
Source: Comamonas testosteroni. Organism_taxid: 285. Atcc: 11996. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D (253 residues) CATH domain: 3.40.50.720
1so8
Abeta-bound human abad structure [also known as 3-hydroxyacy dehydrogenase type ii (type ii hadh), endoplasmic reticulum associated amyloid beta-peptide binding protein (erab)]
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hadh2, erab, xh98g2, schad. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (208 residues) CATH domain: 3.40.50.720
1u7t
Crystal structure of abad/hsd10 with a bound inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hadh2, erab, xh98g2, schad. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (255 residues) CATH domain: 3.40.50.720
2o23
The structure of wild-type human hadh2 (17beta-hydroxysteroi dehydrogenase type 10) bound to NAD+ at 1.2 a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hadh2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (248 residues) CATH domain: 3.40.50.720