_EC 1.1.1.38 Malate dehydrogenase (oxaloacetate-decarboxylating). 15 PDB entries  
EC 1.-.-.- Oxidoreductases. [8,653 PDB entries]
EC 1.1.-.- Acting on the CH-OH group of donors. [1,874 PDB entries]
EC 1.1.1.- With NAD(+) or NADP(+) as acceptor. [1,685 PDB entries]
EC 1.1.1.38 Malate dehydrogenase (oxaloacetate-decarboxylating). [15 PDB entries]    
1do8

Reaction: (1) (S)-malate + NAD(+) = pyruvate + CO(2) + Nadh. (2) Oxaloacetate = pyruvate + CO(2).
 


(S)-malate
+
NAD(+)
=
pyruvate
+
CO(2)
+
NADH

Oxaloacetate
=
pyruvate
+
CO(2)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Malic enzyme. NAD-malic enzyme. Pyruvic-malic carboxylase.
Comments: Unlike Ec 1.1.1.39, this enzyme can also decarboxylate oxaloacetate, cf. Ec 1.1.1.40.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 15 PDB entries in enzyme class E.C.1.1.1.38

  PDB code Protein
1do8
Crystal structure of a closed form of human mitochondrial NAD(p)+-dependent malic enzyme
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (553 residues) CATH domains: 3.40.50.10380 3.40.50.720
Bound ligands:   Het Group NAD corresponds to enzyme reactant NAD(+)
  Het Group OXL is 71.00% similar to enzyme product pyruvate
1efk
Structure of human malic enzyme in complex with ketomalonate
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (553 residues) CATH domains: 3.40.50.10380 3.40.50.720
Bound ligands:   Het Group NAD corresponds to enzyme reactant NAD(+)
  Het Group MAK is 75.00% similar to enzyme product pyruvate
1efl
Human malic enzyme in a quaternary complex with NAD, mg, and tartronate
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (553 residues) CATH domains: 3.40.50.10380 3.40.50.720
Bound ligands:   Het Group NAD corresponds to enzyme reactant NAD(+)
  Het Group TTN is 75.00% similar to enzyme product pyruvate
1gz3
Molecular mechanism for the regulation of human mitochondria NAD(p)+-dependent malic enzyme by atp and fumarate
Source: Homo sapiens. Human. Organism_taxid: 9606. Organelle: mitochondrion
Chains: A, B, C, D (554 residues) CATH domains: 3.40.50.10380 3.40.50.720
Bound ligands:   Het Group FUM is 88.89% similar to enzyme reactant (S)-malate
  Het Group ATP is 56.25% similar to enzyme reactant NAD(+)
  Het Group OXL is 71.43% similar to enzyme product pyruvate
1gz4
Molecular mechanism of the regulation of human mitochondrial NAD(p)+-dependent malic enzyme by atp and fumarate
Source: Homo sapiens. Human. Organism_taxid: 9606. Organelle: mitochondrion
Chains: A, B, C, D (551 residues) CATH domains: 3.40.50.10380 3.40.50.720
Bound ligands:   Het Group FUM is 88.89% similar to enzyme reactant (S)-malate
  Het Group ATP is 56.25% similar to enzyme reactant NAD(+)
  Het Group TTN is 75.00% similar to enzyme product pyruvate
1llq
Crystal structure of malic enzyme from ascaris suum complexe nicotinamide adenine dinucleotide
Source: Ascaris suum. Pig roundworm. Organism_taxid: 6253
Chains: A, B (599 residues) CATH domains: Unassigned Unassigned 3.40.50.10380 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
1o0s
Crystal structure of ascaris suum malic enzyme complexed wit
Source: Ascaris suum. Pig roundworm. Organism_taxid: 6253
Chains: A, B (602 residues) CATH domains: Unassigned Unassigned 3.40.50.10380 3.40.50.720
Bound ligands:   Het Group NAI corresponds to enzyme reactant NAD(+)
  Het Group TTN is 75.00% similar to enzyme product pyruvate
1pj2
Crystal structure of human mitochondrial NAD(p)+-dependent malic enzyme in a pentary complex with natural substrate malate, cofactor nadh, mn++, and allosteric activator fumarate
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: me2. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (553 residues) CATH domains: 3.40.50.10380 3.40.50.720
Bound ligands:   Het Group MLT corresponds to enzyme reactant (S)-malate
  Het Group NAI corresponds to enzyme reactant NAD(+)
1pj3
Crystal structure of human mitochondrial NAD(p)+-dependent malic enzyme in a pentary complex with natural substrate pyruvate, cofactor NAD+, mn++, and allosteric activator fumarate.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: me2. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (553 residues) CATH domains: 3.40.50.10380 3.40.50.720
Bound ligands:   Het Group FUM is 88.00% similar to enzyme reactant (S)-malate
  Het Group NAD corresponds to enzyme reactant NAD(+)
  Het Group PYR corresponds to enzyme product pyruvate
1pj4
Crystal structure of human mitochondrial NAD(p)+-dependent malic enzyme in a pentary complex with natural substrate malate, atp, mn++, and allosteric activator fumarate.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: me2. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (552 residues) CATH domains: 3.40.50.10380 3.40.50.720
Bound ligands:   Het Group MLT corresponds to enzyme reactant (S)-malate
  Het Group ATP is 56.00% similar to enzyme reactant NAD(+)
1pjl
Crystal structure of human m-NAD-me in ternary complex with NAD and lu3+
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: me2. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D, E, F, G, H (551 residues) CATH domains: 3.40.50.10380 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
1qr6
Human mitochondrial NAD(p)-dependent malic enzyme
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (551 residues) CATH domains: 3.40.50.10380 3.40.50.720
Bound ligand:   Het Group NAD corresponds to enzyme reactant NAD(+)
1vl6
Crystal structure of NAD-dependent malic enzyme (tm0542) fro thermotoga maritima at 2.61 a resolution
Source: Thermotoga maritima. Organism_taxid: 243274. Strain: msb8. Gene: tm0542. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (377 residues) CATH domains: 3.40.50.10380 3.40.50.720
2a9f
Crystal structure of a putative malic enzyme ((s)- malate:nad+ oxidoreductase (decarboxylating))
Source: Streptococcus pyogenes. Organism_taxid: 1314. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (383 residues) CATH domains: 3.40.50.10380 3.40.50.720
2hae
Crystal structure of a putative malic enzyme (malate oxidoreductase)
Source: Thermotoga maritima. Organism_taxid: 2336. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (373 residues) CATH domains: 3.40.50.10380 3.40.50.720