_EC 1.1.1.34 Hydroxymethylglutaryl-CoA reductase (NADPH). 22 PDB entries  
EC 1.-.-.- Oxidoreductases. [8,653 PDB entries]
EC 1.1.-.- Acting on the CH-OH group of donors. [1,874 PDB entries]
EC 1.1.1.- With NAD(+) or NADP(+) as acceptor. [1,685 PDB entries]
EC 1.1.1.34 Hydroxymethylglutaryl-CoA reductase (NADPH). [22 PDB entries]    
1dq8

Pathway: Mevalonate Biosynthesis
Reaction: (R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 Nadph.
 


(R)-mevalonate
+
CoA
+
2 × NADP(+)
=
(S)-3-hydroxy-3-methylglutaryl-CoA
+
2 × NADPH
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): 3-hydroxy-3-methylglutaryl-coenzyme A reductase. HMG-CoA reductase.
Comments: The enzyme is inactivated by Ec 2.7.11.31 and reactivated by Ec 3.1.3.47.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 22 PDB entries in enzyme class E.C.1.1.1.34

  PDB code Protein
1dq8
Complex of the catalytic portion of human hmg-coa reductase with hmg and coa
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (417 residues) CATH domains: 1.10.3270.10 3.90.770.10 3.30.70.420
Bound ligands:   Het Group MAH is 90.00% similar to enzyme reactant (R)-mevalonate
  Het Group COA is 82.00% similar to enzyme product (S)-3-hydroxy-3-methylglutaryl-CoA
1dq9
Complex of catalytic portion of human hmg-coa reductase with hmg-coa
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (405 residues) CATH domains: 1.10.3270.10 3.90.770.10 3.30.70.420
Bound ligand:   Het Group HMG corresponds to enzyme product (S)-3-hydroxy-3-methylglutaryl-CoA
1dqa
Complex of the catalytic portion of human hmg-coa reductase with hmg, coa, and NADP+
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (409 residues) CATH domains: 1.10.3270.10 3.90.770.10 3.30.70.420
Bound ligands:   Het Group MAH is 90.00% similar to enzyme reactant (R)-mevalonate
  Het Group NAP corresponds to enzyme reactant NADP(+)
  Het Group COA is 82.00% similar to enzyme product (S)-3-hydroxy-3-methylglutaryl-CoA
1hw8
Complex of the catalytic portion of human hmg-coa reductase compactin (also known as mevastatin)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hmgcr. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (404 residues) CATH domains: 1.10.3270.10 3.90.770.10 3.30.70.420
Bound ligand:   Het Group ADP is 56.25% similar to enzyme reactant CoA
1hw9
Complex of the catalytic portion of human hmg-coa reductase simvastatin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hmgcr. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (408 residues) CATH domains: 1.10.3270.10 3.90.770.10 3.30.70.420
Bound ligand:   Het Group ADP is 56.25% similar to enzyme reactant CoA
1hwi
Complex of the catalytic portion of human hmg-coa reductase with fluvastatin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hmgcr. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (393 residues) CATH domains: 1.10.3270.10 3.90.770.10 3.30.70.420
Bound ligand:   Het Group ADP is 56.00% similar to enzyme reactant NADP(+)
1hwj
Complex of the catalytic portion of human hmg-coa reductase with cerivastatin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hmgcr. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (410 residues) CATH domains: 1.10.3270.10 3.90.770.10 3.30.70.420
Bound ligand:   Het Group ADP is 56.00% similar to enzyme reactant NADP(+)
1hwk
Complex of the catalytic portion of human hmg-coa reductase with atorvastatin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hmgcr. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (408 residues) CATH domains: 1.10.3270.10 3.90.770.10 3.30.70.420
Bound ligand:   Het Group ADP is 56.00% similar to enzyme reactant NADP(+)
1hwl
Complex of the catalytic portion of human hmg-coa reductase with rosuvastatin (formally known as zd4522)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hmgcr. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (407 residues) CATH domains: 1.10.3270.10 3.90.770.10 3.30.70.420
Bound ligand:   Het Group ADP is 56.00% similar to enzyme reactant NADP(+)
2q1l
Design and synthesis of pyrrole-based, hepatoselective hmg-c reductase inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hmgcr. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (392 residues) CATH domains: 1.10.3270.10 3.90.770.10 3.30.70.420
2q6b
Design and synthesis of novel, conformationally restricted hmg-coa reductase inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hmgcr. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (425 residues) CATH domains: 1.10.3270.10 3.90.770.10 3.30.70.420
2q6c
Design and synthesis of novel, conformationally restricted hmg-coa reductase inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hmgcr. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (421 residues) CATH domains: 1.10.3270.10 3.90.770.10 3.30.70.420
2r4f
Substituted pyrazoles as hepatselective hmg-coa reductase inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hmgcr. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (420 residues) CATH domains: 1.10.3270.10 3.90.770.10 3.30.70.420
3bgl
Hepatoselectivity of statins: design and synthesis of 4- sulfamoyl pyrroles as hmg-coa reductase inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hmgcr. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (421 residues) CATH domains: 1.10.3270.10 3.90.770.10 3.30.70.420
3cct
Thermodynamic and structure guided design of statin hmg-coa reductase inhibitors
Source: Homo sapiens. Human. Gene: hmgcr. Expressed in: escherichia coli.
Chains: A, B, C, D (421 residues) CATH domains: 1.10.3270.10 3.90.770.10 3.30.70.420
3ccw
Thermodynamic and structure guided design of statin hmg-coa reductase inhibitors
Source: Homo sapiens. Human. Gene: hmgcr. Expressed in: escherichia coli.
Chains: A, B, C, D (421 residues) CATH domains: 1.10.3270.10 3.90.770.10 3.30.70.420
3ccz
Thermodynamic and structure guided design of statin hmg-coa reductase inhibitors
Source: Homo sapiens. Human. Gene: hmgcr. Expressed in: escherichia coli.
Chains: A, B, C, D (420 residues) CATH domains: 1.10.3270.10 3.90.770.10 3.30.70.420
3cd0
Thermodynamic and structure guided design of statin hmg-coa reductase inhibitors
Source: Homo sapiens. Human. Gene: hmgcr. Expressed in: escherichia coli.
Chains: A, B, C, D (421 residues) CATH domains: 1.10.3270.10 3.90.770.10 3.30.70.420
3cd5
Thermodynamic and structure guided design of statin hmg-coa reductase inhibitors
Source: Homo sapiens. Human. Gene: hmgcr. Expressed in: escherichia coli.
Chains: A, B, C, D (425 residues) CATH domains: 1.10.3270.10 3.90.770.10 3.30.70.420
3cd7
Thermodynamic and structure guided design of statin hmg-coa reductase inhibitors
Source: Homo sapiens. Human. Gene: hmgcr. Expressed in: escherichia coli.
Chains: A, B, C, D (392 residues) CATH domains: 1.10.3270.10 3.90.770.10 3.30.70.420
3cda
Thermodynamic and structure guided design of statin hmg-coa reductase inhibitors
Source: Homo sapiens. Human. Gene: hmgcr. Expressed in: escherichia coli.
Chains: A, B, C, D (422 residues) CATH domains: 1.10.3270.10 3.90.770.10 3.30.70.420
3cdb
Thermodynamic and structure guided design of statin hmg-coa reductase inhibitors
Source: Homo sapiens. Human. Gene: hmgcr. Expressed in: escherichia coli.
Chains: A, B, C, D (421 residues) CATH domains: 1.10.3270.10 3.90.770.10 3.30.70.420